Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Howard Schulman"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Mutations in the genes encoding calcium/calmodulin dependent protein kinase II (CAMK2) isoforms cause a newly recognized neurodevelopmental disorder (ND), for which the full clinical spectrum has yet to be described. Here we report the detailed descr
Externí odkaz:
https://doaj.org/article/9f7edc4829ef4b9a8a52115aa1eb07e9
Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
Autor:
Moitrayee Bhattacharyya, Young Kwang Lee, Serena Muratcioglu, Baiyu Qiu, Priya Nyayapati, Howard Schulman, Jay T Groves, John Kuriyan
Publikováno v:
eLife, Vol 9 (2020)
The many variants of human Ca2+/calmodulin-dependent protein kinase II (CaMKII) differ in the lengths and sequences of disordered linkers connecting the kinase domains to the oligomeric hubs of the holoenzyme. CaMKII activity depends on the balance b
Externí odkaz:
https://doaj.org/article/e288fb9b9a424e16af273300c1822e2a
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1006796 (2019)
The calcium calmodulin-dependent protein kinase II (CaMKII) is a dodecameric holoenzyme important for encoding memory. Its activation, triggered by binding of calcium-calmodulin, persists autonomously after calmodulin dissociation. One (receiver) kin
Externí odkaz:
https://doaj.org/article/20b6f0f71b4a4ccfaf8109d424bb9a27
Autor:
Moitrayee Bhattacharyya, Margaret M Stratton, Catherine C Going, Ethan D McSpadden, Yongjian Huang, Anna C Susa, Anna Elleman, Yumeng Melody Cao, Nishant Pappireddi, Pawel Burkhardt, Christine L Gee, Tiago Barros, Howard Schulman, Evan R Williams, John Kuriyan
Publikováno v:
eLife, Vol 5 (2016)
Activation triggers the exchange of subunits in Ca2+/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We
Externí odkaz:
https://doaj.org/article/495a7e27d1bf4339b6867892a9602ba0
Autor:
Margaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves, John Kuriyan
Publikováno v:
eLife, Vol 3 (2014)
Externí odkaz:
https://doaj.org/article/1d4c8c19cb6a4e0e93766980c0287302
Autor:
Margaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves, John Kuriyan
Publikováno v:
eLife, Vol 3 (2014)
The activation of the dodecameric Ca2+/calmodulin dependent kinase II (CaMKII) holoenzyme is critical for memory formation. We now report that CaMKII has a remarkable property, which is that activation of the holoenzyme triggers the exchange of subun
Externí odkaz:
https://doaj.org/article/e7ee2a33b9b94a1986048d7a6b38acc5
Autor:
Paul Ashwood, Blythe A Corbett, Aaron Kantor, Howard Schulman, Judy Van de Water, David G Amaral
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19299 (2011)
Autism is a neurodevelopmental disorder characterized by impairments in social behavior, communication difficulties and the occurrence of repetitive or stereotyped behaviors. There has been substantial evidence for dysregulation of the immune system
Externí odkaz:
https://doaj.org/article/c85cdc97248847e18f82073f0a35e25d
Autor:
Yevgeniy A Grigoryev, Sunil M Kurian, Zafi Avnur, Dominic Borie, Jun Deng, Daniel Campbell, Joanna Sung, Tania Nikolcheva, Anthony Quinn, Howard Schulman, Stanford L Peng, Randolph Schaffer, Jonathan Fisher, Tony Mondala, Steven Head, Stuart M Flechner, Aaron B Kantor, Christopher Marsh, Daniel R Salomon
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13358 (2010)
A major challenge for the field of transplantation is the lack of understanding of genomic and molecular drivers of early post-transplant immunity. The early immune response creates a complex milieu that determines the course of ensuing immune events
Externí odkaz:
https://doaj.org/article/2fea5ea758d448d288171a6b5a16dfe2
Autor:
Andy Hudmon, Howard Schulman
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e633e49a4022a21a971eaf0816b56a33
https://doi.org/10.1016/b978-0-12-819460-7.00099-2
https://doi.org/10.1016/b978-0-12-819460-7.00099-2
Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
Autor:
Priya Nyayapati, John Kuriyan, Jay T. Groves, Serena Muratcioglu, Young Kwang Lee, Howard Schulman, Baiyu Qiu, Moitrayee Bhattacharyya
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
The activity of Ca2+/calmodulin-dependent protein kinase II (CaMKII) depends on the balance between activating and inhibitory autophosphorylation (Thr 286 and Thr 305/306, respectively, in the human α isoform). Variation in the lengths of the flexib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ebb713818595ed9ef35b3534430b1b
http://europepmc.org/articles/PMC7141811
http://europepmc.org/articles/PMC7141811