Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Howard S. Rosenzweig"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6039-6048
Twenty three 3-nitrotriazole- and five nitroimidazole-based compounds, mostly amides, were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv (Mtb H37Rv) under aerobic or low oxygen conditions, intracellular activity in mur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917ac43333235c819dbd12286662da54
https://doi.org/10.1016/j.bmc.2017.09.037
https://doi.org/10.1016/j.bmc.2017.09.037
Publikováno v:
European Journal of Medicinal Chemistry. 138:1106-1113
A limited number of novel 3-nitrotriazole- and 2-nitroimidazole-linked quinolines and quinazolines were synthesized and screened for in vitro antitrypanosomal and antitubercular activities as well as cytotoxicity in normal cells. All compounds were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7358990f9d9727d51c116393c0df688
https://doi.org/10.1016/j.ejmech.2017.07.060
https://doi.org/10.1016/j.ejmech.2017.07.060
Autor:
Shane R. Wilkinson, William D. Bloomer, Marcel Kaiser, Maria V. Papadopoulou, Howard S. Rosenzweig, Joanna Szular
Publikováno v:
European Journal of Medicinal Chemistry
A small series of 5-nitro-2-aminothiazole-based amides containing arylpiperazine-, biphenyl- or aryloxyphenyl groups in their core were synthesized and evaluated as antitrypanosomatid agents. All tested compounds were active or moderately active agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b00932745986569b98ac2aece062dda
Autor:
Marcel Kaiser, Ivan P. O'Shea, Maria V. Papadopoulou, William D. Bloomer, Jean-Robert Ioset, Shane R. Wilkinson, Eric Chatelain, Howard S. Rosenzweig
Publikováno v:
Bioorganic & Medicinal Chemistry. 23(19):6467-6476
3-Nitro-1H-1,2,4-triazole- and 2-nitro-1H-imidazole-based amides with an aryloxy-phenyl core were synthesized and evaluated as antitrypanosomal agents. All 3-nitrotriazole-based derivatives were extremely potent anti-Trypanosoma cruzi agents at sub n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740a0580eb0a34be1147a2a13371b0ed
Autor:
William D. Bloomer, Howard S. Rosenzweig, Maria V. Papadopoulou, Marcel Kaiser, Shane R. Wilkinson, Ivan P. O'Shea
Publikováno v:
European Journal of Medicinal Chemistry. 103:325-334
Novel linear 3-nitro-1H-1,2,4-triazole-based piperazides were synthesized and evaluated as antitrypanosomal agents. In addition, some bisarylpiperazine-ethanones which were formed as by-products were also screened for antiparasitic activity. Most 3-n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22caf79ccafd34ce47912abc1f8fdbb0
Autor:
Howard S. Rosenzweig, Marcel Kaiser, William D. Bloomer, Maria V. Papadopoulou, Eric Chatelain, Jean-Robert Ioset
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:6600-6607
We have previously shown that 3-nitro-1H-1,2,4-triazole-based amines demonstrate significant trypanocidal activity, in particular against Trypanosoma cruzi, the causative parasite of Chagas disease. In the present work we further expanded our researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a81cefc800a5d6d906e26263fa96a8
https://doi.org/10.1016/j.bmc.2013.08.022
https://doi.org/10.1016/j.bmc.2013.08.022
Publikováno v:
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 15:219-231
Nitro(imidazole/triazole)-linked acridines (NLAs) have been previously developed in our laboratory as DNA-intercalating bioreductive drugs. Such compounds demonstrate toxicity through the formation of bulky monoadducts with cellular macromolecules up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38723273270eaa8178070bd4798c7a9e
https://doi.org/10.3727/096504005776382288
https://doi.org/10.3727/096504005776382288
Publikováno v:
Chemistry and Physics of Lipids. 129:183-194
The novel cationic triester of phosphatidylcholine, O-4-napthylimido-1-butyl-dioleoylphosphatidylcholine (NB-DOPC), has been synthesized: 1-amino-4-butanol was reacted with napthylic anhydride to form 4-hydroxybutyl-1-napthylamide, which was then rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ced9c74c997b770c6f0b05e84f44d5
https://doi.org/10.1016/j.chemphyslip.2004.01.003
https://doi.org/10.1016/j.chemphyslip.2004.01.003
Autor:
Francisco Arrieta, Howard S. Rosenzweig, Alexander Arena, Maria V. Papadopoulou, Joseph C. J. Rebolledo, Diane K. Smith, William D. Bloomer
Publikováno v:
Antimicrobial agents and chemotherapy. 58(11)
Twenty-three 3-nitrotriazole-based and 2-nitroimidazole-based amides and sulfonamides were screened for antitubercular (anti-TB) activity in aerobic Mycobacterium tuberculosis H37Rv by using the BacTiter-Glo (BTG) microbial cell viability assay. In g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce944b3fb7076496283a1d70c1477f7
https://pubmed.ncbi.nlm.nih.gov/25182645
https://pubmed.ncbi.nlm.nih.gov/25182645
Autor:
Marcel Kaiser, Shane R. Wilkinson, Howard S. Rosenzweig, William D. Bloomer, Maria V. Papadopoulou
Publikováno v:
European journal of medicinal chemistry. 87
We have previously shown that 3-nitro-1H-1,2,4-triazole-based arylamides and arylsulfonamides demonstrate significant activity in vitro against Trypanosoma cruzi, the causative parasite of Chagas disease. More importantly, several such analogs displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a601a86dce2edc7791f37f117a741d8
https://pubmed.ncbi.nlm.nih.gov/25240098
https://pubmed.ncbi.nlm.nih.gov/25240098