Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Howard S, Young"'
Autor:
Pu Chen, Tayla J. Van Oers, Elena Arutyunova, Conrad Fischer, Chaoxiang Wang, Tess Lamer, Marco J. van Belkum, Howard S. Young, John C. Vederas, M. Joanne Lemieux
Publikováno v:
JACS Au, Vol 4, Iss 8, Pp 3217-3227 (2024)
Externí odkaz:
https://doaj.org/article/43087000c76649d4af843aa50a0189fd
Autor:
Elena Arutyunova, Alexandr Belovodskiy, Pu Chen, Muhammad Bashir Khan, Michael Joyce, Holly Saffran, Jimmy Lu, Zoe Turner, Bing Bai, Tess Lamer, Howard S. Young, John C. Vederas, D. Lorne Tyrrell, M. Joanne Lemieux, James A. Nieman
Publikováno v:
ACS Bio & Med Chem Au, Vol 3, Iss 6, Pp 528-541 (2023)
Externí odkaz:
https://doaj.org/article/b8e37dea5f004761a5ac48cc97ba66e2
Autor:
Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were original
Externí odkaz:
https://doaj.org/article/3c902c5ef40f40398c856f91dffa7d74
Autor:
Jimmy Lu, Sizhu Amelia Chen, Muhammad Bashir Khan, Raelynn Brassard, Elena Arutyunova, Tess Lamer, Wayne Vuong, Conrad Fischer, Howard S. Young, John C. Vederas, M. Joanne Lemieux
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Coronaviruses infect a variety of hosts in the animal kingdom, and while each virus is taxonomically different, they all infect their host via the same mechanism. The coronavirus main protease (Mpro, also called 3CLpro), is an attractive target for d
Externí odkaz:
https://doaj.org/article/10bc0488429546de95a3dbd8df1e6b43
Autor:
Razieh Kamali-Jamil, Ester Vázquez-Fernández, Brian Tancowny, Vineet Rathod, Sara Amidian, Xiongyao Wang, Xinli Tang, Andrew Fang, Assunta Senatore, Simone Hornemann, Sandor Dudas, Adriano Aguzzi, Howard S Young, Holger Wille
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009628 (2021)
Bovine spongiform encephalopathy (BSE) is a prion disease of cattle that is caused by the misfolding of the cellular prion protein (PrPC) into an infectious conformation (PrPSc). PrPC is a predominantly α-helical membrane protein that misfolds into
Externí odkaz:
https://doaj.org/article/85deff398ef147c1801b95f8303a4f6d
Autor:
M'Lynn E Fisher, Elisa Bovo, Rodrigo Aguayo-Ortiz, Ellen E Cho, Marsha P Pribadi, Michael P Dalton, Nishadh Rathod, M Joanne Lemieux, L Michel Espinoza-Fonseca, Seth L Robia, Aleksey V Zima, Howard S Young
Publikováno v:
eLife, Vol 10 (2021)
The sarco-plasmic reticulum calcium pump (SERCA) plays a critical role in the contraction-relaxation cycle of muscle. In cardiac muscle, SERCA is regulated by the inhibitor phospholamban. A new regulator, dwarf open reading frame (DWORF), has been re
Externí odkaz:
https://doaj.org/article/87991ab8aa184f75a15e117bb6842178
Autor:
Andy Y. Liu, Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Publikováno v:
Biochemistry. 62:1331-1336
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d3f8238f1163f2b665995e520daaf7
https://doi.org/10.1021/acs.biochem.3c00026
https://doi.org/10.1021/acs.biochem.3c00026
Autor:
Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu, Muhammad Bashir Khan, Wioletta Rut, Mikolaj Zmudzinski, Shima Shahbaz, Jegan Iyyathurai, Eman W. Moussa, Zoe Turner, Bing Bai, Tess Lamer, James A. Nieman, John C. Vederas, Olivier Julien, Marcin Drag, Shokrollah Elahi, Howard S. Young, M. Joanne Lemieux
Publikováno v:
ACS Central Science. 9:696-708
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06bc781507dacd5fb23130306731addf
https://doi.org/10.1021/acscentsci.3c00054
https://doi.org/10.1021/acscentsci.3c00054
Autor:
Nishadh Rathod, Jessi J. Bak, Joseph O. Primeau, M’Lynn E. Fisher, Lennane Michel Espinoza-Fonseca, Mary Joanne Lemieux, Howard S. Young
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8891 (2021)
The sarco-endoplasmic reticulum calcium ATPase (SERCA) is responsible for maintaining calcium homeostasis in all eukaryotic cells by actively transporting calcium from the cytosol into the sarco-endoplasmic reticulum (SR/ER) lumen. Calcium is an impo
Externí odkaz:
https://doaj.org/article/13b74f511ec647bf913c3f3b653074f4
Autor:
Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu, Muhammad Bashir Khan, Wioletta Rut, Mikolaj Zmudzinski, Shima Shahbaz, Jegan Iyyathurai, Eman Moussa, Zoe Turner, Bing Bai, Tess Lamer, James A. Nieman, John C. Vederas, Olivier Julien, Marcin Drag, Shokrollah Elahi, Howard S. Young, M. Joanne Lemieux
Main protease of SARS-CoV-2 (Mpro) is the most promising drug target against coronaviruses due to its essential role in virus replication. With newly emerging variants there is a concern that mutations in Mpromay alter structural and functional prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee9208612c8234925406e453eff6a5a
https://doi.org/10.1101/2023.01.28.525917
https://doi.org/10.1101/2023.01.28.525917
