Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Howard Ray Sauls"'
Autor:
Andy Blanchard, Bjørn Sivertsen, Peter Johannes Holst, Howard Ray Sauls, Kevin R. Page, Tau Benned-Jensen, Robert Jepras, Christopher Smethurst, Mette M. Rosenkilde, Thue W. Schwartz
Publikováno v:
Journal of Biological Chemistry. 286:29292-29302
The Epstein-Barr virus-induced receptor 2 (EBI2) is a constitutively active seven-transmembrane receptor, which was recently shown to orchestrate the positioning of B cells in the follicle. To date, no ligands, endogenously or synthetic, have been id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::390df3b54de1833816ba9d6521d6cef0
https://doi.org/10.1074/jbc.m110.196345
https://doi.org/10.1074/jbc.m110.196345
Autor:
Sarva M. Tadepalli, Howard Ray Sauls, Yulin Wu, Andrew J. Carpenter, Yun Xu, Shane M. Hart, Daniel J. Gomez, Judith D. Kuntz, Jing Fang, Carina Ammala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2577-2581
A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3204ac2ccf78b0d83d6cb1e3e1e3c15a
https://doi.org/10.1016/j.bmcl.2010.02.083
https://doi.org/10.1016/j.bmcl.2010.02.083
Autor:
Paul R. Johnson, Dallas K. Croom, Sarah R. Bullard, Sean Ross, Ronald L. Brashear, James M. Way, Christopher R. Conlee, Shane M. Hart, Carina Ammala, Vicente Samano, James B. Thompson, Doug Minick, Yun Xu, Dennis Heyer, Shane Roller, Eric E. Boros, Sarva M. Tadepalli, Peckham Gregory, Andrew J. Carpenter, Jennifer A. Kashatus, Subba Reddy Katamreddy, Howard Ray Sauls, Richard Dana Caldwell, Celia P. Briscoe
Publikováno v:
Journal of medicinal chemistry. 55(24)
GPR119 is a 7-transmembrane receptor that is expressed in the enteroendocrine cells in the intestine and in the islets of Langerhans in the pancreas. Indolines and 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines were discovered as G protein-coupled receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042ec05713cf4401600aefc83d2b88d2
https://pubmed.ncbi.nlm.nih.gov/23214471
https://pubmed.ncbi.nlm.nih.gov/23214471
Autor:
Howard Ray Sauls, Thomas J. Rimele, Channa K Jayawickreme, Terry P. Kenakin, David Moncol, Chris Watson
Publikováno v:
Current Protocols in Pharmacology
The melanophore bioassay is a robust, sensitive, and versatile procedure for screening G protein–coupled receptors in a variety of formats. Because melanophores contain a wide variety of G proteins, they can be employed as a sensitive, real-time re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1422d290b24a9c8eac7b72d00f0cc25d
https://doi.org/10.1002/0471141755.ph1209s29
https://doi.org/10.1002/0471141755.ph1209s29
Autor:
Timothy M. Willson, Dennis B. Lubahn, Howard Ray Sauls, Philip G. Baer, Tanya M. Momtahen, Paul S. Charifson, Beverly B. Oliver, Brad R. Henke, Linda B. Moore, James A. Triantafillou, Steven G. Wolfe, Kenneth William Batchelor
Publikováno v:
Journal of Medicinal Chemistry. 37:1550-1552
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed48926ccb0bc1d0193462b6a4fd57e
https://doi.org/10.1021/jm00037a002
https://doi.org/10.1021/jm00037a002
Autor:
Shelagh Wilson, Kong B. Tan, Diane M. Ignar, Mohammad Tadayyon, Michelle M. Eilert, Catherine E. Ellis, Lisa D. Spinage, Jay C. Strum, Nabil Elshourbagy, Howard Ray Sauls, Jon K. Chambers, James M. Way, William G. Benson, Paul R. Murdock, Celia P. Briscoe, Aaron S. Goetz, Dana T. Minnick, Alison I. Muir, E. John L. Andrews, Usman Shabon, Philip G. Szekeres
Publikováno v:
The Journal of biological chemistry. 278(13)
GPR40 is a member of a subfamily of homologous G protein-coupled receptors that include GPR41 and GPR43 and that have no current function or ligand ascribed. Ligand fishing experiments in HEK293 cells expressing human GPR40 revealed that a range of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1072c39791690b4050d10fb95386087f
https://pubmed.ncbi.nlm.nih.gov/12826323
https://pubmed.ncbi.nlm.nih.gov/12826323
Autor:
Timothy M. Willson, Donald P. McDonnell, Philip G. Baer, David C. Morris, S. Wolfe, I. Asplin, Brad R. Henke, H. R. Brown, Stacey A. Jones, John D. Norris, Brandee L. Wagner, Howard Ray Sauls
Publikováno v:
Endocrinology. 138(9)
The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. However, the mechanism by which these compounds manifest their activity in bone is unknown. We have used a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01b1ac82443f445b106ceb9572bd3a8
https://pubmed.ncbi.nlm.nih.gov/9275080
https://pubmed.ncbi.nlm.nih.gov/9275080