Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Howard R. Seay"'
Autor:
Matthew E. Brown, Leeana D. Peters, Seif R. Hanbali, Juan M. Arnoletti, Lindsey K. Sachs, Kayla Q. Nguyen, Emma B. Carpenter, Howard R. Seay, Christopher A. Fuhrman, Amanda L. Posgai, Melanie R. Shapiro, Todd M. Brusko
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Regulatory T cell (Treg) adoptive cell therapy (ACT) represents an emerging strategy for restoring immune tolerance in autoimmune diseases. Tregs are commonly purified using a CD4+CD25+CD127lo/- gating strategy, which yields a mixed population: 1) ce
Externí odkaz:
https://doaj.org/article/ee8774329b694e21a6e707bc96062b84
Autor:
Peter S. Linsley, Fariba Barahmand-pour-Whitman, Elisa Balmas, Hannah A. DeBerg, Kaitlin J. Flynn, Alex K. Hu, Mario G. Rosasco, Janice Chen, Colin O’Rourke, Elisavet Serti, Vivian H. Gersuk, Keshav Motwani, Howard R. Seay, Todd M. Brusko, William W. Kwok, Cate Speake, Carla J. Greenbaum, Gerald T. Nepom, Karen Cerosaletti
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single-cell RNA sequencing (scRNA-Seq) to identify T cell receptors (TCRs) in IAR T cells, we have identifie
Externí odkaz:
https://doaj.org/article/ae78e844c0644847af1e433a33d6fd7d
Autor:
Keshav Motwani, Leeana D. Peters, Willem H. Vliegen, Ahmed Gomaa El-sayed, Howard R. Seay, M. Cecilia Lopez, Henry V. Baker, Amanda L. Posgai, Maigan A. Brusko, Daniel J. Perry, Rhonda Bacher, Joseph Larkin, Michael J. Haller, Todd M. Brusko
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The human T lymphocyte compartment is highly dynamic over the course of a lifetime. Of the many changes, perhaps most notable is the transition from a predominantly naïve T cell state at birth to the acquisition of antigen-experienced memory and eff
Externí odkaz:
https://doaj.org/article/99b03748c4ef44f296bba8a3bcfeb3b1
Autor:
Seung-Chul Choi, Anton A. Titov, Georges Abboud, Howard R. Seay, Todd M. Brusko, Derry C. Roopenian, Shahram Salek-Ardakani, Laurence Morel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
T cell functions depend on distinct metabolic fluxes. Here the authors show different metabolic requirements of humoral responses to self versus microbial antigens: while glucose is dispensable for antiviral Tfh and antibody responses, it is essentia
Externí odkaz:
https://doaj.org/article/3e0a1f8d30674ceda6619fa064e835de
Autor:
Howard R. Seay, Amy L. Putnam, Judit Cserny, Amanda L. Posgai, Emma H. Rosenau, John R. Wingard, Kate F. Girard, Morey Kraus, Angela P. Lares, Heather L. Brown, Katherine S. Brown, Kristi T. Balavage, Leeana D. Peters, Ashley N. Bushdorf, Mark A. Atkinson, Jeffrey A. Bluestone, Michael J. Haller, Todd M. Brusko
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 178-191 (2017)
Umbilical cord blood is a traditional and convenient source of cells for hematopoietic stem cell transplantation. Thymic regulatory T cells (Tregs) are also present in cord blood, and there is growing interest in the use of autologous Tregs to provid
Externí odkaz:
https://doaj.org/article/b5555cc4f2ea4d9793b448e24da450ff
Autor:
Wen-I Yeh, Howard R. Seay, Brittney Newby, Amanda L. Posgai, Filipa Botelho Moniz, Aaron Michels, Clayton E. Mathews, Jeffrey A. Bluestone, Todd M. Brusko
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The ability to alter antigen specificity by T-cell receptor (TCR) or chimeric antigen receptor (CAR) gene transfer has facilitated personalized cellular immune therapies in cancer. Inversely, this approach can be harnessed in autoimmune settings to a
Externí odkaz:
https://doaj.org/article/d3e8c9b8b451484cb864024ea6531c85
Autor:
Matthew E, Brown, Leeana D, Peters, Seif R, Hanbali, Juan M, Arnoletti, Lindsey K, Sachs, Kayla Q, Nguyen, Emma B, Carpenter, Howard R, Seay, Christopher A, Fuhrman, Amanda L, Posgai, Melanie R, Shapiro, Todd M, Brusko
Publikováno v:
Frontiers in immunology. 13
Regulatory T cell (Treg) adoptive cell therapy (ACT) represents an emerging strategy for restoring immune tolerance in autoimmune diseases. Tregs are commonly purified using a CD4
Autor:
Keshav Motwani, Mikael Knip, Howard R. Seay, Anssi Kailaanmäki, Jorma Ilonen, Henna Ilmonen, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Aurélien Azam, Emmi-Leena Ihantola, Tuure Kinnunen, Todd M. Brusko, Bernard Maillere, Marja Rytkönen-Nissinen, Jorma Toppari, Riitta Veijola
Publikováno v:
J Immunol
Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease in which the insulin-producing β cells within the pancreas are destroyed. Identification of target Ags and epitopes of the β cell–reactive T cells is important both for understanding
Autor:
Elisavet Serti, Todd M. Brusko, Keshav Motwani, Fariba Barahmand-pour-Whitman, Karen Cerosaletti, Colin O’Rourke, Alex Hu, Peter S. Linsley, Janice Chen, Gerald T. Nepom, Elisa Balmas, Carla J. Greenbaum, Cate Speake, William W. Kwok, Hannah A. DeBerg, Kaitlin J. Flynn, Mario G. Rosasco, Howard R. Seay, Vivian H. Gersuk
Publikováno v:
JCI Insight
Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single-cell RNA sequencing (scRNA-Seq) to identify T cell receptors (TCRs) in IAR T cells, we have identifie
Autor:
Wen-I Yeh, Mark A. Atkinson, Michael J. Haller, Andrew Muir, Scott E. Stimpson, Amanda L. Posgai, Joseph W. Dean, Leeana D. Peters, Todd M. Brusko, Clayton E. Mathews, Christopher Fuhrman, Howard R. Seay, Daniel J. Perry, Brittney N. Newby, Maigan A. Brusko
Publikováno v:
J Autoimmun
IL-12 and IL-18 synergize to promote T(H)1 responses and have been implicated as accelerators of autoimmune pathogenesis in type 1 diabetes (T1D). We investigated the influence of these cytokines on immune cells involved in human T1D progression: nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afab662d800ddf98077959a16fe16e5f
https://europepmc.org/articles/PMC7086400/
https://europepmc.org/articles/PMC7086400/