Zobrazeno 1 - 10 of 176 pro vyhledávání: '"Howard M. Temin"'
1
High rates of frameshift mutations within homo-oligomeric runs during a single cycle of retroviral replication
Autor: Howard M. Temin, D. P. W. Burns
Publikováno v: Journal of Virology. 68:4196-4203
Homo-oligomeric runs were inserted into a spleen necrosis virus-based retrovirus vector to determine the nature and rate of mutations within runs of 10 to 12 identical nucleotides during a single replication cycle. Clones of helper cells containing i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708708f0ebc24da6ce641891278d4cb3
https://doi.org/10.1128/jvi.68.7.4196-4203.1994
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2
Copackaging of different-sized retroviral genomic RNAs: little effect on retroviral replication or recombination
Autor: Howard M. Temin, J S Jones, B Seufzer, R W Allan
Publikováno v: Journal of Virology. 68:4097-4103
We tested the effect of copackaging retroviral vectors of different sizes on retroviral replication and recombination. Our results indicate little or no difference in replication or in the rate or pattern of the strand transfers leading to the format
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1b0149caf0deef9f579738f01f9527
https://doi.org/10.1128/jvi.68.6.4097-4103.1994
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3
Retrovirus recombination depends on the length of sequence identity and is not error prone
Autor: Jiayou Zhang, Howard M. Temin
Publikováno v: Journal of Virology. 68:2409-2414
Retroviruses, as a result of the presence of two identical genomic RNA molecules in their virions, recombine at a high rate. When nonhomologous RNA is present in the dimer RNA molecules, nonhomologous recombination can occur, although the rate is ver
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0e73dda6e264c8b866d11f4e7cc526
https://doi.org/10.1128/jvi.68.4.2409-2414.1994
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4
One retroviral RNA is sufficient for synthesis of viral DNA
Autor: J S Jones, R W Allan, Howard M. Temin
Publikováno v: Journal of Virology. 68:207-216
We used previously characterized spleen necrosis virus-based retroviral vectors and helper cells to study the strand transfers that occur during the reverse-transcription phase of a single cycle of retroviral replication. The conditions used selected
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533905884054776aab0617263cdc0d99
https://doi.org/10.1128/jvi.68.1.207-216.1994
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5
Lower mutation rate of bovine leukemia virus relative to that of spleen necrosis virus
Autor: Howard M. Temin, Louis M. Mansky
Publikováno v: Journal of Virology. 68:494-499
Genetic variation of the more complex retroviruses in the human T-cell leukemia virus/bovine leukemia virus (HTLV/BLV) group is less than in some other retroviral genera. To test whether reverse transcription of HTLV/BLV group members is less error p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffb3c2fed3a65114482aeeb9b4daa33
https://doi.org/10.1128/jvi.68.1.494-499.1994
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6
Alteration of location of dimer linkage sequence in retroviral RNA: little effect on replication or homologous recombination
Autor: R W Allan, Howard M. Temin, J S Jones
Publikováno v: Journal of Virology. 67:3151-3158
Retrovirus particles contain a dimer of retroviral genomic RNA. A defined region of the retrovirus genome has previously been shown to be important for both dimerization and encapsidation. To study the importance of the position of this encapsidation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2070256a6e20004a5e7de488d6e4290
https://doi.org/10.1128/jvi.67.6.3151-3158.1993
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9
Retroviral Recombination and Reverse Transcription
Autor: Howard M. Temin, Wei-Shau Hu
Publikováno v: Science. 250:1227-1233
Recombination occurs at a high rate in retroviral replication, and its observation requires a virion containing two different RNA molecules (heterodimeric particles). Analysis of retroviral recombinants formed after a single round of replication reve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e48abc6ff54e38987052e795eb78fb
https://doi.org/10.1126/science.1700865
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10
Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions
Autor: Howard M. Temin, Vinay K. Pathak
Publikováno v: Proceedings of the National Academy of Sciences. 87:6024-6028
In the preceding paper we described an experiment that determined the in vivo forward mutation rate in a single replication cycle for spleen necrosis virus. In addition to substitutions, frameshifts, and hypermutations, the mutated proviruses contain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703fff6f862452390f0879b5657ae6f7
https://doi.org/10.1073/pnas.87.16.6024
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