Výsledky vyhledávání - "Howard M. Grey"

Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals

Autor: Véronique, Schulten, Jason A, Greenbaum, Michael, Hauser, Denise M, McKinney, John, Sidney, Ravi, Kolla, Cecilia S, Lindestam Arlehamn, Carla, Oseroff, Rapheul, Alam, David H, Broide, Fatima, Ferreira, Fatima, Ferreira-Briza, Howard M, Grey, Alessandro, Sette, Bjoern, Peters

Publikováno v: Proceedings of the National Academy of Sciences. 110:3459-3464

T cells play an important role in the pathogenesis of allergic diseases. However, the proteins considered as potential immunogens of allergenic T-cell responses have traditionally been limited to those that induce IgE responses. Timothy grass (TG) po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aefb6dfaf75c9797f774929351a5034
https://doi.org/10.1073/pnas.1300512110

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T Cell Responses to Known Allergen Proteins Are Differently Polarized and Account for a Variable Fraction of Total Response to Allergen Extracts

Autor: Randi Vita, David H. Broide, Jason A. Greenbaum, Howard M. Grey, Tess M. Brodie, Victoria Tripple, Bjoern Peters, Scott Southwood, Rafeul Alam, John Sidney, Federica Sallusto, Carla Oseroff, Ravi Kolla, Denise M. McKinney, Alessandro Sette

Publikováno v: The Journal of Immunology. 189:1800-1811

A panel of 133 allergens derived from 28 different sources, including fungi, trees, grasses, weeds, and indoor allergens, was surveyed utilizing prediction of HLA class II-binding peptides and ELISPOT assays with PBMC from allergic donors, resulting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85067e9939fe28be4b631c87d3aefac6
https://doi.org/10.4049/jimmunol.1200850

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Insights into HLA-Restricted T Cell Responses in a Novel Mouse Model of Dengue Virus Infection Point toward New Implications for Vaccine Design

Autor: Aruna D. De Silva, Ravi Kolla, Michael A. Angelo, Lauren E. Yauch, Aravinda M. de Silva, Jason A. Greenbaum, Alessandro Sette, John Sidney, Bjoern Peters, Daniela Weiskopf, Howard M. Grey, Daisy V. John, Sujan Shresta

Publikováno v: The Journal of Immunology. 187:4268-4279

The frequency of dengue virus (DENV) infection has increased dramatically in the last few decades, and the lack of a vaccine has led to significant morbidity and mortality worldwide. To date, a convenient murine system to study human T cell responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47bd17d9997e93cca17c97475d1605bd
https://doi.org/10.4049/jimmunol.1101970

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Correlates of protection efficacy induced by vaccinia virus-specific CD8+T-cell epitopes in the murine intranasal challenge model

Autor: Shahram Salek-Ardakani, Alessandro Sette, Michael Croft, John Sidney, Howard M. Grey, Magdalini Moutaftsi, Bjoern Peters

Publikováno v: European Journal of Immunology. 39:717-722

The recent identification of a large array of different vaccinia virus-derived CD8+ T-cell epitopes offers a unique opportunity to systematically analyze the correlation between protective efficacy and variables such as kinetics of expression and fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab05c151bb51235e7eef4ad22cc3204f
https://doi.org/10.1002/eji.200838815

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Immunomic Analysis of the Repertoire of T-Cell Specificities for Influenza A Virus in Humans

Autor: Howard M. Grey, John Sidney, Huynh-Hoa Bui, Alessandro Sette, Jean Glenn, Qing Zhang, Mark Newman, Innocent N. Mbawuike, Erika Assarsson, Carla Oseroff, Jeff Alexander

Publikováno v: Journal of Virology. 82:12241-12251

Continuing antigenic drift allows influenza viruses to escape antibody-mediated recognition, and as a consequence, the vaccine currently in use needs to be altered annually. Highly conserved epitopes recognized by effector T cells may represent an al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd295aca241981d199ba5004f65a3e62
https://doi.org/10.1128/jvi.01563-08

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Naive Precursor Frequencies and MHC Binding Rather Than the Degree of Epitope Diversity Shape CD8+ T Cell Immunodominance

Autor: Alessandro Sette, Howard M. Grey, Iain Scott, Tom Wolfe, Bjoern Peters, Matthias von Herrath, Hilde Cheroutre, Maya F. Kotturi, Michael J. Buchmeier, John Sidney

Publikováno v: The Journal of Immunology. 181:2124-2133

The primary CD8+ T cell response of C57BL/6J mice against the 28 known epitopes of lymphocytic choriomeningitis virus (LCMV) is associated with a clear immunodominance hierarchy whose mechanism has yet to be defined. To evaluate the role of epitope c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a321e7f2215bed1ec708dd54ab40f0d9
https://doi.org/10.4049/jimmunol.181.3.2124

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Dissociation between Epitope Hierarchy and Immunoprevalence in CD8 Responses to Vaccinia Virus Western Reserve

Autor: Howard M. Grey, Alessandro Sette, Magdalini Moutaftsi, Vijay Panchanathan, Carla Oseroff, Bjoern Peters, David C. Tscharke, John Sidney, Bernard Maillere, Valerie Pasquetto

Publikováno v: The Journal of Immunology. 180:7193-7202

Understanding immunity to vaccinia virus (VACV) is important for the development of safer vaccines for smallpox- and poxvirus-vectored recombinant vaccines. VACV is also emerging as an outstanding model for studying CD8+ T cell immunodominance becaus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8bda8aabf3f06b44718c2b8c76fe21
https://doi.org/10.4049/jimmunol.180.11.7193

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Analysis of epitope information related toBacillus anthracisandClostridium botulinum

Autor: Arturo Casadevall, Bjoern Peters, Laura Zarebski, Kim D. Janda, Alessandro Sette, Kerrie Vaughan, John Sidney, Howard M. Grey

Publikováno v: Expert Review of Vaccines. 7:55-74

We have reviewed the information about epitopes of immunological interest from Clostridium botulinum and Bacillus anthracis, by mining the Immune Epitope Database and Analysis Resource. For both pathogens, the vast majority of epitopes reported to da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16fc9cd187651ec55ffa4d59d2fc97b3
https://doi.org/10.1586/14760584.7.1.55

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A Quantitative Analysis of the Variables Affecting the Repertoire of T Cell Specificities Recognized after Vaccinia Virus Infection

Autor: Howard M. Grey, Christian Brander, Valerie Pasquetto, Erika Assarsson, Nicole Frahm, Alessandro Sette, Carla Oseroff, Bjoern Peters, Huynh-Hoa Bui, John Sidney

Publikováno v: The Journal of Immunology. 178:7890-7901

Many components contribute to immunodominance in the response to a complex virus, but their relative importance is unclear. This was addressed using vaccinia virus and HLA-A*0201 as the model system. A comprehensive analysis of 18 viral proteins reco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44354a07641022841319a65e951b7509
https://doi.org/10.4049/jimmunol.178.12.7890

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Vaccinia Virus-Specific CD4+ T Cell Responses Target a Set of Antigens Largely Distinct from Those Targeted by CD8+ T Cell Responses

Autor: Shane Crotty, Shahram Salek-Ardakani, John Sidney, Howard M. Grey, Magdalini Moutaftsi, Huynh-Hoa Bui, Bjoern Peters, Alessandro Sette, Carla Oseroff, Elliot J. Lefkowitz, Valerie Pasquetto, Michael Croft

Publikováno v: The Journal of Immunology. 178:6814-6820

Recent studies have defined vaccinia virus (VACV)-specific CD8+ T cell epitopes in mice and humans. However, little is known about the epitope specificities of CD4+ T cell responses. In this study, we identified 14 I-Ab-restricted VACV-specific CD4+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fba82626744d24b5a9577f4cda9716
https://doi.org/10.4049/jimmunol.178.11.6814

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