Výsledky vyhledávání - "Howard M. Cann"

Akademický článek

Transcriptome sequencing from diverse human populations reveals differentiated regulatory architecture.

Autor: Alicia R Martin, Helio A Costa, Tuuli Lappalainen, Brenna M Henn, Jeffrey M Kidd, Muh-Ching Yee, Fabian Grubert, Howard M Cann, Michael Snyder, Stephen B Montgomery, Carlos D Bustamante

Publikováno v: PLoS Genetics, Vol 10, Iss 8, p e1004549 (2014)

Large-scale sequencing efforts have documented extensive genetic variation within the human genome. However, our understanding of the origins, global distribution, and functional consequences of this variation is far from complete. While regulatory v

Externí odkaz: https://doaj.org/article/034634dd18804c91bad00abc6cb5c6c2

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Insights into human genetic variation and population history from 929 diverse genomes

Publikováno v: Science

INTRODUCTION: Large-scale human genome sequencing studies to date have been limited to large, metropolitan populations or to small numbers of genomes from each group. Much remains to be understood about the extent and structure of genetic variation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f59d64f25c414f16049ef25f89093f
https://www.repository.cam.ac.uk/handle/1810/302417

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Akademický článek

Positive selection in the chromosome 16 VKORC1 genomic region has contributed to the variability of anticoagulant response in humans.

Autor: Blandine Patillon, Pierre Luisi, Hélène Blanché, Etienne Patin, Howard M Cann, Emmanuelle Génin, Audrey Sabbagh

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e53049 (2012)

VKORC1 (vitamin K epoxide reductase complex subunit 1, 16p11.2) is the main genetic determinant of human response to oral anticoagulants of antivitamin K type (AVK). This gene was recently suggested to be a putative target of positive selection in Ea

Externí odkaz: https://doaj.org/article/9e6d86977cab4257bbcca362cc407418

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Distance from sub-Saharan Africa predicts mutational load in diverse human genomes

Autor: Laurent Excoffier, Laura R. Botigué, Howard M. Cann, Jeffrey M. Kidd, Shaila Musharoff, Brian K. Maples, Brenna M. Henn, Carlos Bustamante, Michael Snyder, Mikhail Lipatov, Alicia R. Martin, Isabelle Dupanloup, Stephan Peischl

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 4
Proc Natl Acad Sci U S A

The Out-of-Africa (OOA) dispersal ~50,000 years ago is characterized by a series of founder events as modern humans expanded into multiple continents. Population genetics theory predicts an increase of mutational load in populations undergoing serial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c436e2b0db0e8b594aa78dab334835
https://escholarship.org/uc/item/15f7c94w

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Consanguinity around the world: what do the genomic data of the HGDP-CEPH diversity panel tell us?

Autor: Steven Gazal, Howard M. Cann, Anne-Louise Leutenegger, Mourad Sahbatou, Emmanuelle Génin

Publikováno v: European Journal of Human Genetics. 19:583-587

Inbreeding coefficients and consanguineous mating types are usually inferred from population surveys or pedigree studies. Here, we present a method to estimate them from dense genome-wide single-nucleotide polymorphism genotypes and apply it to 940 u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445e96bd722c12c9ec458b280d635af7
https://doi.org/10.1038/ejhg.2010.205

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Building the sequence map of the human pan-genome

Publikováno v: Li, R, Li, Y, Zheng, H, Luo, R, Zhu, H, Li, Q, Qian, W, Ren, Y, Tian, G, Li, J, Zhou, G, Zhu, X, Wu, H, Qin, J, Jin, X, Li, D, Cao, H, Hu, X, Blanche, H, Cann, H, Zhang, X, Li, S, Bolund, L, Kristiansen, K, Yang, H, Wang, J & Wang, J 2009, ' Building the sequence map of the human pan-genome ', Nature Biotechnology, vol. 28, no. 1, pp. 57-63 . https://doi.org/10.1038/nbt.1596

Udgivelsesdato: 2010-Jan Here we integrate the de novo assembly of an Asian and an African genome with the NCBI reference human genome, as a step toward constructing the human pan-genome. We identified approximately 5 Mb of novel sequences not presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609bd7681964cc0fdced3e78fde550e5
https://doi.org/10.1038/nbt.1596

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A Comparison of HLA Data of the North American Black with African Black and North American Caucasoid Populations

Autor: J.F. Shaw, H. Perkins, Rose Payne, Howard M. Cann, F.E. Ward, A. Biegel, Rene J. Duquesnoy, J. G. Bodmer, Marcus W. Feldman, Glenn E. Rodey, P. Stastny

Publikováno v: Tissue Antigens. 9:135-147

For purposes of genetic comparison, the available HLA data on United States and African Black, together with United States Caucasoid populations, are summarized. Antigen frequencies and pairwise linkage disequilibria are presented for the HLA-A, -B a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7dfa90318fadcc4482c560f22160c81
https://doi.org/10.1111/j.1399-0039.1977.tb01095.x

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Genetic Structure of the HL-A System in a Nahua Indian Population in Mexico

Autor: Rose Payne, Howard M. Cann, Ruben Lisker, Kenneth K. Kidd, Ruta Radvany

Publikováno v: Scopus-Elsevier

HL–A phenotype and gene frequencies are presented for a population sample of Nahua Indians from Mexico. These Indians showed restricted variability in the first and second segregant HL–A series as compared to Caucasian, Black and Mongoloid popula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4701babe210cc57f01a5600cac36c3b0
https://doi.org/10.1111/j.1399-0039.1973.tb00505.x

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