Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Howard Lightfoot"'
Autor:
Stacey Price, Shriram Bhosle, Emanuel Gonçalves, Xiaodun Li, Dylan P. McClurg, Syd Barthorpe, Alex Beck, Caitlin Hall, Howard Lightfoot, Luke Farrow, Rizwan Ansari, David A. Jackson, Laura Allen, Kirsty Roberts, Charlotte Beaver, Hayley E. Francies, Mathew J. Garnett
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Organoid cell culture methodologies are enabling the generation of cell models from healthy and diseased tissue. Patient-derived cancer organoids that recapitulate the genetic and histopathological diversity of patient tumours are being syst
Externí odkaz:
https://doaj.org/article/a7bae74b80b04ee1836d4572e3824812
Autor:
Clare Pacini, Joshua M. Dempster, Isabella Boyle, Emanuel Gonçalves, Hanna Najgebauer, Emre Karakoc, Dieudonne van der Meer, Andrew Barthorpe, Howard Lightfoot, Patricia Jaaks, James M. McFarland, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The integration of independent pan-cancer CRISPR-Cas9 datasets allows better representation of genomic heterogeneity across different cancer types. Here, the authors propose a strategy for the integration of two large CRISPR-Cas9 screens and report i
Externí odkaz:
https://doaj.org/article/fdd2ad5966004da891cf74b4446afacf
Autor:
Emanuel Gonçalves, Aldo Segura‐Cabrera, Clare Pacini, Gabriele Picco, Fiona M Behan, Patricia Jaaks, Elizabeth A Coker, Donny van derMeer, Andrew Barthorpe, Howard Lightfoot, Tatiana Mironenko, Alexandra Beck, Laura Richardson, Wanjuan Yang, Ermira Lleshi, James Hall, Charlotte Tolley, Caitlin Hall, Iman Mali, Frances Thomas, James Morris, Andrew R Leach, James T Lynch, Ben Sidders, Claire Crafter, Francesco Iorio, Stephen Fawell, Mathew J Garnett
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 7, Pp n/a-n/a (2020)
Abstract Low success rates during drug development are due, in part, to the difficulty of defining drug mechanism‐of‐action and molecular markers of therapeutic activity. Here, we integrated 199,219 drug sensitivity measurements for 397 unique an
Externí odkaz:
https://doaj.org/article/8d3c7a8706894b218dbc302dbd8ec445
Autor:
Xiaodun Li, Hayley E. Francies, Maria Secrier, Juliane Perner, Ahmad Miremadi, Núria Galeano-Dalmau, William J. Barendt, Laura Letchford, Genevieve M. Leyden, Emma K. Goffin, Andrew Barthorpe, Howard Lightfoot, Elisabeth Chen, James Gilbert, Ayesha Noorani, Ginny Devonshire, Lawrence Bower, Amber Grantham, Shona MacRae, Nicola Grehan, David C. Wedge, Rebecca C. Fitzgerald, Mathew J. Garnett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate and lacks robust preclinical models for use in research. Here, the authors show that newly derived organoids recapitulate the transcriptomic, genetic, and morphological landscape of the
Externí odkaz:
https://doaj.org/article/aa2121583c394435847f94d0542851c4
Autor:
Krishna Kalyan Kolluri, Constantine Alifrangis, Neelam Kumar, Yuki Ishii, Stacey Price, Magali Michaut, Steven Williams, Syd Barthorpe, Howard Lightfoot, Sara Busacca, Annabel Sharkey, Zhenqiang Yuan, Elizabeth K Sage, Sabarinath Vallath, John Le Quesne, David A Tice, Doraid Alrifai, Sylvia von Karstedt, Antonella Montinaro, Naomi Guppy, David A Waller, Apostolos Nakas, Robert Good, Alan Holmes, Henning Walczak, Dean A Fennell, Mathew Garnett, Francesco Iorio, Lodewyk Wessels, Ultan McDermott, Samuel M Janes
Publikováno v:
eLife, Vol 7 (2018)
Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear de
Externí odkaz:
https://doaj.org/article/f8b56a1949f54101aa89a88d500f0a18
Autor:
Kirsty Roberts, Rizwan Ansari, Howard Lightfoot, Hayley E. Francies, Caitlin Hall, Andrew Barthorpe, Emanuel Gonçalves, Xiaodon Li, Luke Farrow, Stacey Price, Laura Allen, David A. Jackson, Charlotte M. Beaver, Mathew J. Garnett, Alex Beck, Shriram G. Bhosle, Dylan McClurg
Organoid cell culture methodologies are enabling the generation of cell models from healthy and diseased tissue. Patient-derived cancer organoids that recapitulate the genetic and histopathological diversity of patient tumours are being systematicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a794d830da11db0d643f1b97ba896f46
Autor:
Lisa Dwane, Francesco Iorio, Howard Lightfoot, Wanjuan Yang, Mathew J. Garnett, Miguel Pignatelli, Emanuel Gonçalves, Rebecca Shepherd, Dieudonne van der Meer, Fiona M. Behan
Publikováno v:
Nucleic Acids Research
CRISPR genetic screens in cancer cell models are a powerful tool to elucidate oncogenic mechanisms and to identify promising therapeutic targets. The Project Score database (https://score.depmap.sanger.ac.uk/) uses genome-wide CRISPR–Cas9 dropout s
Autor:
Emanuel Gonçalves, Rebecca C. Poulos, Zhaoxiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yangxiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip J. Robinson, Qing Zhong, Mathew J. Garnett, Roger R. Reddel
Publikováno v:
Cancer Cell
The proteome provides unique insights into disease biology beyond the genome and transcriptome. A lack of large proteomic datasets has restricted the identification of new cancer biomarkers. Here, proteomes of 949 cancer cell lines across 28 tissue t
Autor:
Patricia Jaaks, Elizabeth A. Coker, Daniel J. Vis, Olivia Edwards, Emma F. Carpenter, Simonetta M. Leto, Lisa Dwane, Francesco Sassi, Howard Lightfoot, Syd Barthorpe, Dieudonne van der Meer, Wanjuan Yang, Alexandra Beck, Tatiana Mironenko, Caitlin Hall, James Hall, Iman Mali, Laura Richardson, Charlotte Tolley, James Morris, Frances Thomas, Ermira Lleshi, Nanne Aben, Cyril H. Benes, Andrea Bertotti, Livio Trusolino, Lodewyk Wessels, Mathew J. Garnett
Publikováno v:
NATURE
Nature: international weekly journal of science, 603(7899)
Nature: international weekly journal of science, 603(7899)
Combinations of anti-cancer drugs can overcome resistance and provide new treatments1,2. The number of possible drug combinations vastly exceeds what could be tested clinically. Efforts to systematically identify active combinations and the tissues a
Autor:
Emre Karakoc, Hanna Najgebauer, Howard Lightfoot, Mathew J. Garnett, Patricia Jaaks, Emanuel Gonçalves, Clare Pacini, Joshua M. Dempster, Aviad Tsherniak, James M. McFarland, Francesco Iorio, Isabella Boyle, Andrew Barthorpe, Dieudonne van der Meer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CRISPR-Cas9 viability screens are increasingly performed at a genome-wide scale across large panels of cell lines to identify new therapeutic targets for precision cancer therapy. Integrating the datasets resulting from these studies is necessary to