Zobrazeno 1 - 10
of 698
pro vyhledávání: '"Howard L, McLeod"'
Autor:
Julia C.F. Quintanilha, Alexander B. Sibley, Yingmiao Liu, Donna Niedzwiecki, Susan Halabi, Layne Rogers, Bert O’Neil, Hedy Kindler, William Kelly, Alan Venook, Howard L. McLeod, Mark J. Ratain, Andrew B. Nixon, Federico Innocenti, Kouros Owzar
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Herein, we report results from a genome-wide study conducted to identify protein quantitative trait loci (pQTL) for circulating angiogenic and inflammatory protein markers in patients with metastatic colorectal cancer (mCRC). The
Externí odkaz:
https://doaj.org/article/363d6f8837684c528d797df314a685cf
Autor:
Yang Wang, Fan Xiao, Yi Zhao, Chen-Xue Mao, Lu-Lu Yu, Lei-Yun Wang, Qi Xiao, Rong Liu, Xi Li, Howard L. McLeod, Bi-Wen Hu, Yu-Ling Huang, Qiao-Li Lv, Xiao-Xue Xie, Wei-Hua Huang, Wei Zhang, Cheng-Xian Guo, Jin-Gao Li, Ji-Ye Yin
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Background Genetic variants associated with acute side effects of radiotherapy in nasopharyngeal carcinoma (NPC) remain largely unknown. Methods We performed a two-stage genome-wide association analysis including a total of 1084 patients, wh
Externí odkaz:
https://doaj.org/article/cf97c8e5fbb84b9e8bdc34653d6628ec
Autor:
Jiali Hu, Ruitao Lu, Yu Zhang, Wei Li, Qian Hu, Cuiyu Chen, Zhaoqian Liu, Wei Zhang, Ling Chen, Ran Xu, Jia Luo, Howard L. McLeod, Yijing He
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Background Oncolytic viruses (OVs) are considered a promising therapeutic alternative for cancer. However, OVs could activate the host innate immunity, then impair the viral propagation in tumor cells. In this study, we explored the effect o
Externí odkaz:
https://doaj.org/article/e25fcc546df545339b2034d78d4652ad
Autor:
George W. Small, Farida S. Akhtari, Adrian J. Green, Tammy M. Havener, Michael Sikes, Julia Quintanhila, Ricardo D. Gonzalez, David M. Reif, Alison A. Motsinger-Reif, Howard L. McLeod, Tim Wiltshire
Publikováno v:
Cells, Vol 12, Iss 12, p 1574 (2023)
Monoclonal antibody (mAb) therapy directed against CD20 is an important tool in the treatment of B cell disorders. However, variable patient response and acquired resistance remain important clinical challenges. To identify genetic factors that may i
Externí odkaz:
https://doaj.org/article/fc45090c563c425fbc7ecb27e7e70be1
Autor:
Ricardo D. Gonzalez, George W. Small, Adrian J. Green, Farida S. Akhtari, Tammy M. Havener, Julia C. F. Quintanilha, Amber B. Cipriani, David M. Reif, Howard L. McLeod, Alison A. Motsinger-Reif, Tim Wiltshire
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 726 (2023)
Temozolomide (TMZ) chemotherapy is an important tool in the treatment of glioma brain tumors. However, variable patient response and chemo-resistance remain exceptionally challenging. Our previous genome-wide association study (GWAS) identified a sug
Externí odkaz:
https://doaj.org/article/57e65b5154c4450e9438e8a07a74bd2b
Autor:
Ricardo D. Gonzalez, George W. Small, Adrian J. Green, Farida S. Akhtari, Alison A. Motsinger-Reif, Julia C. F. Quintanilha, Tammy M. Havener, David M. Reif, Howard L. McLeod, Tim Wiltshire
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 757 (2023)
Oxaliplatin (OXAL) is a commonly used chemotherapy for treating colorectal cancer (CRC). A recent genome wide association study (GWAS) showed that a genetic variant (rs11006706) in the lncRNA gene MKX-AS1 and partnered sense gene MKX could impact the
Externí odkaz:
https://doaj.org/article/8aa3c245cb8d4f288b8d1ffcb9ff9422
Autor:
Yang Wang, Fan Xiao, Yan Chen, Le‐Dong Xiao, Lei‐Yun Wang, Yan Zhan, Xing‐Liang Xiong, Gang Zhou, Rong Liu, Dong‐Sheng Ouyang, Zhi Li, Howard L McLeod, Wei Zhang, Qing Li, Zhao‐Qian Liu, Hong‐Hao Zhou, Ji‐Ye Yin
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 11, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/08df8a317d404a3192441ea694092ebf
Autor:
Jiali Hu, Cuiyu Chen, Ruitao Lu, Yu Zhang, Yang Wang, Qian Hu, Wanting Li, Shiyu Wang, Ouyang Jing, Hanying Yi, Wei Zhang, Ling Chen, Weihua Huang, Jia Luo, Howard L. McLeod, Ran Xu, Yijing He
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Oncolytic viruses (OVs) are considered a promising therapeutic alternative for cancer. However, despite the development of novel OVs with improved efficacy and tumor selectivity, their limited efficacy as monotherapeutic agents remains a significant
Externí odkaz:
https://doaj.org/article/bcb621cfd54f4eba8fe580f5ae4a0791
Autor:
Lu Zhang, Howard L McLeod, Ke-Ke Liu, Wen-Hui Liu, Hang-Xing Huang, Ya-Min Huang, Shu-Sen Sun, Xiao-Ping Chen, Yao Chen, Fang-Zhou Liu, Jian Xiao
Publikováno v:
JMIR mHealth and uHealth, Vol 9, Iss 9, p e33223 (2021)
Externí odkaz:
https://doaj.org/article/44a9c04a4e19497d9e8cd41a9eba4fb0
Autor:
Lu Zhang, Howard L McLeod, Ke-Ke Liu, Wen-Hui Liu, Hang-Xing Huang, Ya-Min Huang, Shu-Sen Sun, Xiao-Ping Chen, Yao Chen, Fang-Zhou Liu, Jian Xiao
Publikováno v:
JMIR mHealth and uHealth, Vol 9, Iss 8, p e24555 (2021)
BackgroundSelf-management of ambulatory cancer pain is full of challenges. Motivated by the need for better pain management, we developed a WeChat-supported platform, Medication Housekeeper (MediHK), to enhance communication, optimize outcomes, and p
Externí odkaz:
https://doaj.org/article/77e6757d1c04422dae330559d08ea2b3