Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Howard J. Stamato"'
Autor:
James A. Searles, Howard J. Stamato
Publikováno v:
Drying Technologies for Biotechnology and Pharmaceutical Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b99ba0af3574f3db7671a2a1ccbd20b7
https://doi.org/10.1002/9783527802104.ch12
https://doi.org/10.1002/9783527802104.ch12
Optimizing Knowledge Creation at Bristol-Myers Squibb—a Case Study within Pharmaceutical Development
Autor:
Manisha Dali, Thomas Raglione, Ronald W. Behling, Jean W. Tom, Andrew Stewart, Howard J. Stamato
Publikováno v:
Journal of Pharmaceutical Innovation. 10:1-12
The drug development process is a long complex multidisciplinary endeavor. Much of the activity to support the registration and manufacture of a new medicine is developed in the area known as chemistry, manufacturing, and controls (CMC) in reference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c80eb9c11718cb7252aec0716d54f11
https://doi.org/10.1007/s12247-014-9209-y
https://doi.org/10.1007/s12247-014-9209-y
Autor:
Scott Thibault, Howard J. Stamato, Kenneth Williams, Wei Chen, Keirnan R. LaMarche, James M. Parker
Publikováno v:
Powder Technology. 235:115-120
Experimental operation of three fluidized bed processors is compared with CFD simulation results. The capacities of the fluidized bed processors represent two orders of magnitude scale-up. Qualitative fluidization patterns as well as quantitative dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9de6c7ca9bdece15f66fd06fe293808e
https://doi.org/10.1016/j.powtec.2012.09.021
https://doi.org/10.1016/j.powtec.2012.09.021
Autor:
Shruti Gour, Christopher Levins, Brian M. Zacour, Howard J. Stamato, Preetanshu Pandey, Steve Pafiakis, David Buckley, Shasad Sharif, Dilbir S. Bindra, Jade Trinh
Publikováno v:
Pharmaceutical development and technology. 23(6)
The objective of this study was to improve the disintegration and dissolution characteristics of a highly water-soluble tablet matrix by altering the manufacturing process. A high disintegration time along with high dependence of the disintegration t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76e303fea317656dab72be4762ca19b
https://pubmed.ncbi.nlm.nih.gov/27879156
https://pubmed.ncbi.nlm.nih.gov/27879156
Autor:
Shih-Ying Chang, Jennifer Wang, Alexander J. Marchut, Wei Chen, San Kiang, Olav Lyngberg, Divyakant Desai, William Early, Venkatramana M. Rao, Howard J. Stamato
Publikováno v:
Journal of Pharmaceutical Sciences. 99:3213-3225
We developed an engineering model for predicting the active pharmaceutical ingredient (API) content uniformity (CU) for a drug product in which the active is coated onto a core. The model is based on a two-zone mechanistic description of the spray co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15571e0e3aabd5c54e2f37c5b94307e1
https://doi.org/10.1002/jps.22044
https://doi.org/10.1002/jps.22044
Autor:
Mark R. Smith, Osama Sudah, Steve Hammond, David J. Goldfarb, Marcos Llusa, Hanu Ramachandruni, Fernando J. Muzzio, Howard J. Stamato, Kurt Sturm
Publikováno v:
Industrial & Engineering Chemistry Research. 48:93-101
This paper examines the effect of three protocols with several units and blender parameters on the mitigation of active pharmaceutical ingredient (API) agglomeration in solid formulations. The three protocols either preblend API with a portion of exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfcbd51300f8555c59213a249b5c2334
https://doi.org/10.1021/ie8007055
https://doi.org/10.1021/ie8007055
Autor:
Jeffrey N. Hemenway, Howard J. Stamato, Varia Sailesh Amilal, Ajit S. Narang, Srinivasa Paruchuri, Levons Jaquan Kalani, Rao V. Mantri, Yongmei Wu, Thiago C. Carvalho
Publikováno v:
Excipient Applications in Formulation Design and Drug Delivery ISBN: 9783319202051
Reactive impurities in excipients are often the attributed cause of drug product instability. Development of an excipient and drug product control strategy requires detailed understanding, identification, and quantitation of the rate and extent of fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe17821176136eed00ee64429d41df02
https://doi.org/10.1007/978-3-319-20206-8_4
https://doi.org/10.1007/978-3-319-20206-8_4
Autor:
Howard J. Stamato, Admassu Abebe, Kyle Martin, Kottala Niranjan Kumar, Antara Majumdar, Rekha Keluskar, Jason Franck
Publikováno v:
Pharmaceutical development and technology. 20(2)
There has been increasing interest in fixed dose combination (FDC) therapy. Multi-layer tablets are a popular choice among various technologies to deliver FDCs. In most cases, round flat faced tooling is used in testing tablets as they have the simpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335d9c9ba9217d43071251a5a3d6f51c
https://pubmed.ncbi.nlm.nih.gov/24219774
https://pubmed.ncbi.nlm.nih.gov/24219774
Autor:
Wei Chen, Varia Sailesh Amilal, Shih-Ying Chang, Srinivasa Paruchuri, Jeffrey N. Hemenway, William Early, Jennifer Wang, Divyakant Desai, Howard J. Stamato
Publikováno v:
International journal of pharmaceutics. 427(2)
Effects of material and manufacturing process parameters on the efficiency of an aqueous active tablet film-coating process in a perforated pan coater were evaluated. Twenty-four batches representing various core tablet weights, sizes, and shapes wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e21eadb46b3f35494b943f2ccd4904
https://pubmed.ncbi.nlm.nih.gov/22301427
https://pubmed.ncbi.nlm.nih.gov/22301427