Výsledky vyhledávání - "Howard J. Schaeffer"

6-Deoxyacyclovir: a xanthine oxidase-activated prodrug of acyclovir

Autor: Thomas A. Krenitsky, W W Hall, Howard J. Schaeffer, Lilia M. Beauchamp, P de Miranda, P D Whiteman

Publikováno v: Proceedings of the National Academy of Sciences. 81:3209-3213

Acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] is an acyclic guanine nucleoside analogue that is widely used clinically as an antiherpetic agent. Its limited absorption in humans after oral administration prompted the search for prodrugs. A congener,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b026b22556b05bde8c20018edea9f8f4
https://doi.org/10.1073/pnas.81.10.3209

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Effect of acyclic pyrimidines related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine on herpes viruses

Autor: John E. Kelsey, Jung-Chung Lin, John William Talbot Selway, Howard J. Schaeffer, Barbara L. Serling, Peter Collins, Lilia M. Beauchamp, Karen K. Biron

Publikováno v: Journal of Medicinal Chemistry. 31:144-149

A series of pyrimidines related to the potent antiherpetic agent 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (1, BW B759U), all containing the same acyclic chain, have been synthesized. Some of the compounds were derivatives of the naturally occurring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9019b7d361fe27a53e0e0f8fb794c82e
https://doi.org/10.1021/jm00396a021

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Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities

Autor: Phillip A. Furman, James A. Fyfe, Carol M. Lubbers, Paul M. Keller, Howard J. Schaeffer, Lilia M. Beauchamp, Gertrude B. Elion

Publikováno v: Biochemical Pharmacology. 30:3071-3077

The inhibitor and substrate specificities of deoxythymidine (dThd) kinase purified from herpes simplex virus (HSV Type 1) were studied. A number of nucleosides and nucleoside analogs were phosphorylated by the virus coded enzyme. These included sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f7dbf7302544e8d5586b174ec929dc
https://doi.org/10.1016/0006-2952(81)90495-0

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Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

Autor: Howard J. Schaeffer, Lilia M. Beauchamp, Gertrude B. Elion, Paulo de Miranda, Phillip A. Furman, James A. Fyfe

Publikováno v: Proceedings of the National Academy of Sciences. 74:5716-5720

A guanine derivative with an acyclic side chain, 2-hydroxyethoxymethyl, at position 9 has potent antiviral activity [dose for 50% inhibition (ED 50 ) = 0.1 μM] against herpes simplex virus type 1. This acyclic nucleoside analog, termed acycloguanosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9373ab53fdd8a0488013552e877d45f8
https://doi.org/10.1073/pnas.74.12.5716

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Modifications on the heterocyclic base of acyclovir: syntheses and antiviral properties

Autor: Howard J. Schaeffer, Bart L. Dolmatch, Peter Collins, James A. Fyfe, Paul M. Keller, D. J. Bauer, Lilia M. Beauchamp

Publikováno v: Journal of Medicinal Chemistry. 28:982-987

A group of compounds was prepared in which variations of the ring portion of the acyclovir (ACV) structure were made. These modifications included monocyclic (isocytosine, triazole, imidazole), bicyclic (8-azapurine, pyrrolo[2,3-d]pyrimidine, pyrazol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f79c21d092dbe183da08ed3a6d880d
https://doi.org/10.1021/jm00146a002

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Acyclic Nucleosides. Synthesis and Antiherpetic Activity of 9-[[[2-Hydroxy-1-(Hydroxymethyl)Ethyl]Thio]Methyl]Guanine and 1-[[[2-Hydroxy-1-(Hydroxymethyl)Ethyl]Thio]Methyl]Cytosine

Autor: James A. Linn, Karen K. Biron, Peter Collins, James L. Kelley, Howard J. Schaeffer, John William Talbot Selway, Lilia M. Beauchamp

Publikováno v: Nucleosides and Nucleotides. 8:475-489

The synthesis and antiherpetic activity of 9-[[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]methy1]guanine (4) and 1-[[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]methy]cytosine (6), the side-chain thio analogues of ganciclovir (3) and BW A1117U (5), are descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf1135d364beea1b21ad0cf2042503ee
https://doi.org/10.1080/07328318908054190

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Purine acyclic nucleosides. Nitrogen isosteres of 9-[(2-hydroxyethoxy)methyl] guanine as candidate antivirals

Autor: Howard J. Schaeffer, James L. Kelley, Mark P. Krochmal

Publikováno v: Journal of Medicinal Chemistry. 24:1528-1531

A number of nitrogen analogues of 9-[(2-hydroxyethoxy)methyl]guanine [acylovir, Zovirax] containing amine functions in the side chain were synthesized and tested for antiviral activity. These purine acyclic nucleosides were prepared by reaction of tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b9dd9c5613966280b440290a79f4bf
https://doi.org/10.1021/jm00144a033

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