Výsledky vyhledávání - "Howard J. Latimer"

Effective Targeting of Multiple B-Cell Maturation Antigen–Expressing Hematological Malignances by Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor T Cells

Autor: Tracy E. Garrett, Richard A. Morgan, Howard J. Latimer, Holly M. Horton, Stacie L. Seidel, Kevin Friedman, Christopher J. Horvath, John W. Evans

Publikováno v: Human Gene Therapy. 29:585-601

B-cell maturation antigen (BCMA) expression has been proposed as a marker for the identification of malignant plasma cells in patients with multiple myeloma (MM). Nearly all MM tumor cells express BCMA, while normal tissue expression is restricted to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa5251811ccd48e2d11edd085f465f3
https://doi.org/10.1089/hum.2018.001

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A BCMA-specific CAR T cell produced with clinically scalable lentiviral and T cell manufacturing processes has potent anti-multiple myeloma activity

Autor: Holly M. Horton, Tracy E. Garrett, Christopher J. Horvath, Byoung Y Ryu, Stacie L. Seidel, Kevin Friedman, Howard J. Latimer, John W Evans, Richard A. Morgan, Johanna A Griecci, Alena A Chekmasova

Publikováno v: Journal for Immunotherapy of Cancer

Meeting abstracts Chimeric antigen receptors (CARs) operably link T cell activation domains to the antigen recognition properties of an antibody, thereby redirecting T lymphocytes to cells expressing the antigen. B cell maturation antigen (BCMA) is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b6c7cc22ffbc801b760058b54dcaaf
https://doi.org/10.1186/2051-1426-3-s2-p124

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Abstract 2296: Inhibition of the PI3K/Akt pathway during CAR T cell production results in enhanced efficacy across multiple in vivo tumor models

Autor: Tracy E. Garrett, John W. Evans, Holly M. Horton, Molly Perkins, Claire J. Rhodes, Amanda Hamel, Richard A. Morgan, Shannon Grande, Michael Kuczewski, Howard J. Latimer, Christopher J. Horvath, Kevin G. Friedman, Sara M. Miller, Fay Eng

Publikováno v: Cancer Research. 76:2296-2296

Patients treated with chimeric antigen receptor (CAR) T cells targeting CD19 for B cell malignancies have experienced rapid and durable tumor regressions. Manufacture of CAR T cells for treatment requires ex vivo culture to facilitate CAR gene transf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a671df320268512ce0322848a7eb825
https://doi.org/10.1158/1538-7445.am2016-2296

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Manufacturing an Enhanced CAR T Cell Product By Inhibition of the PI3K/Akt Pathway During T Cell Expansion Results in Improved In Vivo Efficacy of Anti-BCMA CAR T Cells

Autor: Amanda Hamel, Molly Perkins, Shannon Grande, Sara M. Miller, Kevin M. Friedman, Michael Kuczewski, Tracy E. Garrett, Howard J. Latimer, Christopher J. Horvath, Richard A. Morgan, Holly M. Horton

Publikováno v: Blood. 126:1893-1893

Patients treated with chimeric antigen receptor (CAR) T cells targeting CD19 for B cell malignancies have experienced rapid and durable tumor regressions. Manufacture of CAR T cells is challenged by the necessity to produce a unique drug product for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::775dd3fb1ef8d53dce8897565b49f389
https://doi.org/10.1182/blood.v126.23.1893.1893

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A Novel and Highly Potent CAR T Cell Drug Product for Treatment of BCMA-Expressing Hematological Malignances

Autor: John W. Evans, Johanna A Griecci, Kevin Friedman, Tracy E. Garrett, Stacie L. Seidel, Byoung Y. Ryu, Alena A. Chekmasova, Amanda Hamel, Howard J. Latimer, Holly M. Horton, Richard A. Morgan, Christopher J. Horvath, Michael Kuczewski

Publikováno v: Blood. 126:3094-3094

Recently, B cell maturation antigen (BCMA) expression has been proposed as a marker for identification of malignant plasma cells in patients with multiple myeloma (MM). Nearly all MM and some lymphoma tumor cells express BCMA, while normal tissue exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::184ce9b7be5045fbeb3d4cb34a8b1194
https://doi.org/10.1182/blood.v126.23.3094.3094

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Characterization of Lentiviral Vector Derived Anti-Bcma CAR T Cells Reveals Key Parameters for Robust Manufacturing of Cell-Based Gene Therapies for Multiple Myeloma

Autor: Mark D. Angelino, Mingli Li, Laura Viggiano, Gregory Hopkins, Alden Ladd, Michael Kuczewski, Daniel Cossette, Richard A. Morgan, Graham Lilley, Wendy Bakeman, Michael J. Paglia, Kevin Friedman, John W. Evans, Dawn Maier, Kayla MacLeod, Sara M. Miller, Howard J. Latimer

Publikováno v: Blood. 126:3243-3243

T cells engineered with chimeric antigen receptors (CAR) specific to CD19 have caused rapid and durable clinical responses in ~90% of patients with acute lymphoblastic leukemia. These data support the development of additional CAR T cell products for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e389edec19dc7f9f2dc569053a39897
https://doi.org/10.1182/blood.v126.23.3243.3243

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