Výsledky vyhledávání - "Howard I. Duynstee"

A two-step sulfurization for efficient solution-phase synthesis of phosphorothioate oligonucleotides

Autor: Martijn C. de Koning, Amar B. T. Ghisaidoobe, Dmitri V. Filippov, Herman S. Overkleeft, Gijs A. van der Marel, Paul B. W. Ten Kortenaar, Howard I. Duynstee

Publikováno v: Tetrahedron Letters. 49:3129-3132

A solution-phase approach for the synthesis of phosphorothioate oligonucleotides that circumvents the use of chromatographic purifications of protected phosphorothioate intermediates was developed. Implementation of a two-step sulfurization protocol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bea4443f881ac664b60fb358272f3aa0
https://doi.org/10.1016/j.tetlet.2008.03.025

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Simple and Efficient Solution-Phase Synthesis of Oligonucleotides Using Extractive Work-Up

Autor: Amar B. T. Ghisaidoobe, and Dmitri V. Filippov, Howard I. Duynstee, Paul B. W. Ten Kortenaar, Martijn C. de Koning, Gijs A. van der Marel

Publikováno v: Organic Process Research & Development. 10:1238-1245

A solution-phase synthesis protocol amenable to scale-up was developed for the preparation of oligonucleotides employing phosphoramidite chemistry and DMTr/iBu/Bz-protected monomers. Isolation of i...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19cd950c6a227a9d7b0303f3bf97215c
https://doi.org/10.1021/op060133q

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Synthesis of Highly Functionalized Piperidines via a Tandem Retro‐Michael‐[2 + 3]‐Cycloaddition

Autor: Howard I. Duynstee, Mark Overhand, Gijs A. van der Marel, Jacques H. van Boom, Herman S. Overkleeft, John Nielsen, Elisabeth Vang Carstensen

Publikováno v: Journal of Carbohydrate Chemistry. 22:241-252

The highly functionalized piperidine 5a was synthesized in only 4 steps starting from ribose using a tandem retro‐Michael‐[2 + 3]‐cycloaddition process as the key transformation. The versatility of the tandem retro‐Michael‐[2 + 3]‐cycload

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34aa13ae2c81cc409e3db7c5df83bbeb
https://doi.org/10.1081/car-120021703

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Synthesis of Verbascoside: A Dihydroxyphenylethyl Glycoside with Diverse Bioactivity

Autor: Martijn C. de Koning, Gĳs A. van der Marel, Jacques H. van Boom, Howard I. Duynstee, Huib Ovaa

Publikováno v: European Journal of Organic Chemistry. 1999:2623-2632

TMSOTf-mediated condensation of ethyl 4,6-O-benzylidene-1-thio-β-D-glucopyranoside (2) with peracetylated α-L-rhamnopyranosyl trichloroacetimidate donor 3a resulted in the formation of orthoester 4, which, after acetylation, rearranged into ethyl 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7ff5733cf0d7ec7370b210b5249e641
https://doi.org/10.1002/(sici)1099-0690(199910)1999:10<2623::aid-ejoc2623>3.0.co

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An expeditious route to the synthesis of kelampayosides A and B

Autor: Jacques H. van Boom, Howard I. Duynstee, Martijn C. de Koning, Gijs A. van der Marel

Publikováno v: Tetrahedron. 55:9881-9898

Chemoselective NIS/ cat. TfOH-mediated glycosylation of ethyl2,3,4-tri-O-benzoyl-1-thio-β- d -glucopyranoside (13) with ethyl2,3-di-O-acetyl-5-O-benzyl-1-thio-αβ- d -erythro-apiofuranoside (4a) gave dimer14 in an excellent yield. BF3•Et2O-cataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c4f0a7a2f04fcaf94a31f404c0b2c8b
https://doi.org/10.1016/s0040-4020(99)00527-x

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A convenient route to cis- and trans-fused bicyclic ethers by ruthenium mediated ring-closing metathesis of diene and enyne carbohydrate derivatives

Autor: Gijsbert A. van der Marel, Michiel A. Leeuwenburgh, Jacques H. van Boom, Camiel Kulker, Howard I. Duynstee, Herman S. Overkleeft

Publikováno v: Tetrahedron. 55:8253-8262

A general approach towards the construction of highly functionalised pyranopyran and pyranofuran systems via Grubbs [Ru] catalysed ring-closing metatheses of neighbouring vinyl-O-allyl and vinyl-O-propargyl functions on monosaccharide scaffolds is de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c501c5cef464f8b00b9a8501beae462
https://doi.org/10.1016/s0040-4020(99)00296-3

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Structure and Total Synthesis of HF-7, a Neuroactive Glyconucleoside Disulfate from the Funnel-Web Spider Hololena curta

Autor: Kevin D. McCormick, Anke K. van Engen, Gijs A. van der Marel, and Jacques H. van Boom, Bruce Ganem, Howard I. Duynstee, Yingbo Li, Jinping McCormick, Jerrold Meinwald

Publikováno v: Journal of the American Chemical Society. 121:5661-5665

Spider venom toxins have attracted considerable attention for their ability to block the action of excitatory amino acids such as glutamate and aspartate. A new neuroactive compound designated HF-7 was isolated in 1993 from the venom of a funnel-web

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f7ab8fdaca21a73e51b4ccb51f26817
https://doi.org/10.1021/ja990274q

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Synthesis of 3,4,5-trimethoxyphenyl 5″-O-caffeoyl-β-d-erythro-apiofuranosyl-(1→6)-β-d-glucopyranoside: Kelampayoside B

Autor: Gijs A. van der Marel, Jacques H. van Boom, Howard I. Duynstee, Martijn C. de Koning

Publikováno v: Tetrahedron Letters. 39:4129-4132

Chemoselective NIS/ cat. TfOH-mediated glycosylation of ethyl 2,3,4-tri-O-benzoyl-1-thio-β- d -glucopyranoside (4) with ethyl 2,3-di-O-acetyl-5-O-benzyl-1-thio-α/β- d -erythro-apiofuranoside (3) gave dimer 5 in an excellent yield. BF3Et2O-catalyse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a45b2ab4759dd3b8447949cc5b1c0d99
https://doi.org/10.1016/s0040-4039(98)00673-x

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An Efficient Synthesis of (R)-3-{(R)-3-[2-O-(α-L-Rhamnopyranosyl)- α-L-rhamnopyranosyl] oxydecanoyl}oxydecanoic Acid, a Rhamnolipid fromPseudomonas Aeruginosa

Autor: Jacques H. van Boom, Gijsbert A. van der Marel, Howard I. Duynstee, Michiel J. van Vliet

Publikováno v: European Journal of Organic Chemistry. 1998:303-307

N-iodosuccinimide/triflic acid mediated one-pot two-step glycosylation of ethyl 2,3,4-tri-O-benzyl-1-thio-α-L-rhamnopyranoside (8) with phenyl 3,4-O-(2,3-dimethoxybutane-2,3-diyl)-1-thio-α-L-rhamnopyranoside (10b) and phenacyl (R)-3-hydroxydecanoat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b41adb9508c9558b27379b60a4882217
https://doi.org/10.1002/(sici)1099-0690(199802)1998:2<303::aid-ejoc303>3.0.co

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Enzymatic Cleavage ofN-Phenylacetyl-Protected Ethanolamine Phosphates

Autor: Erik de Vroom, Gijsbert A. van der Marel, Howard I. Duynstee, Jacques H. van Boom, Nicole C.R. van Straten

Publikováno v: Liebigs Annalen. 1997:1215-1220

Immobilized penicillin-G acylase mediated removal of the N-phenylacetyl protective group in ethanolamine phosphates 7 and 9 furnished compounds 8 and 10, respectively. Deblocking of N-phenylacetyl-protected ethanolamine phosphate heptosyl disaccharid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::346ec1b5e7631437a1274061aeee59a1
https://doi.org/10.1002/jlac.199719970625

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