Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

Autor: Julien Calderaro, Narmin Ghaffari Laleh, Qinghe Zeng, Pascale Maille, Loetitia Favre, Anaïs Pujals, Christophe Klein, Céline Bazille, Lara R. Heij, Arnaud Uguen, Tom Luedde, Luca Di Tommaso, Aurélie Beaufrère, Augustin Chatain, Delphine Gastineau, Cong Trung Nguyen, Hiep Nguyen-Canh, Khuyen Nguyen Thi, Viviane Gnemmi, Rondell P. Graham, Frédéric Charlotte, Dominique Wendum, Mukul Vij, Daniela S. Allende, Federico Aucejo, Alba Diaz, Benjamin Rivière, Astrid Herrero, Katja Evert, Diego Francesco Calvisi, Jérémy Augustin, Wei Qiang Leow, Howard Ho Wai Leung, Emmanuel Boleslawski, Mohamed Rela, Arnaud François, Anthony Wing-Hung Cha, Alejandro Forner, Maria Reig, Manon Allaire, Olivier Scatton, Denis Chatelain, Camille Boulagnon-Rombi, Nathalie Sturm, Benjamin Menahem, Eric Frouin, David Tougeron, Christophe Tournigand, Emmanuelle Kempf, Haeryoung Kim, Massih Ningarhari, Sophie Michalak-Provost, Purva Gopal, Raffaele Brustia, Eric Vibert, Kornelius Schulze, Darius F. Rüther, Sören A. Weidemann, Rami Rhaiem, Jean-Michel Pawlotsky, Xuchen Zhang, Alain Luciani, Sébastien Mulé, Alexis Laurent, Giuliana Amaddeo, Hélène Regnault, Eleonora De Martin, Christine Sempoux, Pooja Navale, Maria Westerhoff, Regina Cheuk-Lam Lo, Jan Bednarsch, Annette Gouw, Catherine Guettier, Marie Lequoy, Kenichi Harada, Pimsiri Sripongpun, Poowadon Wetwittayaklang, Nicolas Loménie, Jarukit Tantipisit, Apichat Kaewdech, Jeanne Shen, Valérie Paradis, Stefano Caruso, Jakob Nikolas Kather

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

Abstract Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal

Externí odkaz: https://doaj.org/article/ba65186be9624b389ea48c3c89596cfd

Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease

Autor: Thaninee Prasoppokakorn, Wah-Kheong Chan, Vincent Wai-Sun Wong, Panyavee Pitisuttithum, Sanjiv Mahadeva, Nik Raihan Nik Mustapha, Grace Lai-Hung Wong, Howard Ho-Wai Leung, Pimsiri Sripongpun, Sombat Treeprasertsuk

Publikováno v: World Journal of Gastroenterology. 28:1563-1573

Identifying hepatic fibrosis is crucial for nonalcoholic fatty liver disease (NAFLD) management. The fibrosis-8 (FIB-8) score, recently developed by incorporating four additional variables into the fibrosis-4 (FIB-4) score, showed better performance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e0ff3e6e610ea12649778b35eeb7c6
https://doi.org/10.3748/wjg.v28.i15.1563

N-terminal propeptide of type 3 collagen-based sequential algorithm can identify high-risk steatohepatitis and fibrosis in MAFLD

Autor: Liang-Jie Tang, Gang Li, Mohammed Eslam, Pei-Wu Zhu, Sui-Dan Chen, Howard Ho-Wai Leung, Ou-Yang Huang, Grace Lai-Hung Wong, Yu-Jie Zhou, Morten Karsdal, Diana Julie Leeming, Pei Jiang, Cong Wang, Hai-Yang Yuan, Christopher D. Byrne, Giovanni Targher, Jacob George, Vincent Wai-Sun Wong, Ming-Hua Zheng

Publikováno v: Hepatology international.

With metabolic dysfunction-associated fatty liver disease (MAFLD) incidence and prevalence sharply increasing globally, there is an urgent need for non-invasive diagnostic tests to accurately screen high-risk MAFLD patients for liver inflammation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcdf36c0619e990641ceeae649d591d
https://pubmed.ncbi.nlm.nih.gov/36152131

Reliability of the nonalcoholic steatohepatitis clinical research network and steatosis activity fibrosis histological scoring systems

Autor: Howard Ho‐Wai Leung, Pavitratha Puspanathan, Anthony Wing‐Hung Chan, Nik Raihan Nik Mustapha, Vincent Wai‐Sun Wong, Wah‐Kheong Chan

Publikováno v: Journal of gastroenterology and hepatologyReferences. 37(6)

We aimed to determine whether lobular inflammation and ballooning grades in the Non-alcoholic Steatohepatitis Clinical Research Network (NASH CRN) scoring system can be directly translated into the same for the Steatosis Activity Fibrosis scoring sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe196433b35c45b5f1408219e9e0016c
https://pubmed.ncbi.nlm.nih.gov/35362158

Nestin as a diagnostic and prognostic marker for combined hepatocellular-cholangiocarcinoma

Autor: Julien Calderaro, Luca Di Tommaso, Pascale Maillé, Aurélie Beaufrère, Cong Trung Nguyen, Lara Heij, Viviane Gnemmi, Rondell P. Graham, Frédéric Charlotte, Suzanne Chartier, Dominique Wendum, Mukul Vij, Daniela Allende, Alba Diaz, Carla Fuster, Benjamin Rivière, Astrid Herrero, Jérémy Augustin, Katja Evert, Diego Francesco Calvisi, Wei Qiang Leow, Howard Ho Wai Leung, Jan Bednarsch, Emmanuel Boleslawski, Mohamed Rela, Anthony Wing-Hung Chan, Alejandro Forner, Maria Reig, Anaïs Pujals, Loetitia Favre, Manon Allaire, Olivier Scatton, Arnaud Uguen, Eric Trépo, Lukas Otero Sanchez, Denis Chatelain, Myriam Remmelink, Camille Boulagnon-Rombi, Céline Bazille, Nathalie Sturm, Benjamin Menahem, Eric Frouin, David Tougeron, Christophe Tournigand, Emmanuelle Kempf, Haeryoung Kim, Massih Ningarhari, Sophie Michalak-Provost, Jakob Nikolas Kather, Annette S.H. Gouw, Purva Gopal, Raffaele Brustia, Eric Vibert, Kornelius Schulze, Darius F. Rüther, Sören A. Weidemann, Rami Rhaiem, Jean-Charles Nault, Alexis Laurent, Giuliana Amaddeo, Hélène Regnault, Eleonora de Martin, Christine Sempoux, Pooja Navale, Jayendra Shinde, Ketan Bacchuwar, Maria Westerhoff, Regina Cheuk-Lam Lo, Mylène Sebbagh, Catherine Guettier, Marie Lequoy, Mina Komuta, Marianne Ziol, Valérie Paradis, Jeanne Shen, Stefano Caruso

Publikováno v: Journal of Hepatology
Journal of Hepatology, 2022, pp.S0168-8278(22)02983-X. ⟨10.1016/j.jhep.2022.07.019⟩
Journal of Hepatology, Elsevier, 2022, pp.S0168-8278(22)02983-X. ⟨10.1016/j.jhep.2022.07.019⟩
Journal of Hepatology, 77(6), 1586-1597. ELSEVIER SCIENCE BV

Background & Aims: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver cancer (PLC) associated with a poor prognosis. Given the challenges in its identification and its clinical implications, biomarkers are critically needed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e11252a4f5367e397a95b8fb624fa7c
https://pubmed.ncbi.nlm.nih.gov/35987274