Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Howard Gamper"'
Autor:
Sunita Maharjan, Howard Gamper, Yuka Yamaki, Thomas Christian, Robert Y. Henley, Nan-Sheng Li, Takeo Suzuki, Tsutomu Suzuki, Joseph A. Piccirilli, Meni Wanunu, Erin Seifert, Douglas C. Wallace, Ya-Ming Hou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Human mitochondrial tRNAs (mt-tRNAs), critical for mitochondrial biogenesis, are frequently associated with pathogenic mutations. These mt-tRNAs have unusual sequence motifs and require post-transcriptional modifications to stabilize their f
Externí odkaz:
https://doaj.org/article/6beaaf5507164908a32932465f77b163
Autor:
Amr Makhamreh, Sepideh Tavakoli, Ali Fallahi, Xinqi Kang, Howard Gamper, Mohammad Nabizadehmashhadtoroghi, Miten Jain, Ya-Ming Hou, Sara H. Rouhanifard, Meni Wanunu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Chemical modifications to mRNA respond dynamically to environmental cues and are important modulators of gene expression. Nanopore direct RNA sequencing has been applied for assessing the presence of pseudouridine (ψ) modifications through
Externí odkaz:
https://doaj.org/article/e8c24c20290e43c3baa8bfc053081702
Autor:
Sepideh Tavakoli, Mohammad Nabizadeh, Amr Makhamreh, Howard Gamper, Caroline A. McCormick, Neda K. Rezapour, Ya-Ming Hou, Meni Wanunu, Sara H. Rouhanifard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Pseudouridine (psi) is an RNA modification that can affect its physiology, including increased half-life. Here the authors identify sites of psi modification in the human transcriptome using direct RNA sequencing and provide a “ground truth” list
Externí odkaz:
https://doaj.org/article/0d5179a76ab04c11a24ee5827b1cd49c
Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis
Autor:
Zhicheng Cui, Xiaojun Li, Joonyoung Shin, Howard Gamper, Ya-Ming Hou, James C. Sacchettini, Junjie Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The authors present structures of the MtbEttA protein bound to or free of the ribosome from Mycobacterium tuberculosis under different nucleotide states, which provide insights into the mechanism of translational regulation by EttA-like proteins.
Externí odkaz:
https://doaj.org/article/a1ceaf8c8b90485fbe8e0f72e313307d
Autor:
Howard Gamper, Haixing Li, Isao Masuda, D. Miklos Robkis, Thomas Christian, Adam B. Conn, Gregor Blaha, E. James Petersson, Ruben L. Gonzalez, Ya-Ming Hou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Genome recoding with quadruplet codons requires a +1-frameshift-suppressor tRNA able to insert an amino acid at quadruplet codons of interest. Here the authors identify the mechanisms resulting in +1 frameshifting and the steps of the elongation cycl
Externí odkaz:
https://doaj.org/article/f25e7830b887458f96ecdebbbd086160
Autor:
Isao Masuda, Jae-Yeon Hwang, Thomas Christian, Sunita Maharjan, Fuad Mohammad, Howard Gamper, Allen R Buskirk, Ya-Ming Hou
Publikováno v:
eLife, Vol 10 (2021)
N1-methylation of G37 is required for a subset of tRNAs to maintain the translational reading-frame. While loss of m1G37 increases ribosomal +1 frameshifting, whether it incurs additional translational defects is unknown. Here, we address this questi
Externí odkaz:
https://doaj.org/article/a833a1e94d0c41389028df927ab81e6b
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100207- (2020)
Summary: Post-translational addition of amino acids to proteins by enzymes using aminoacyl-tRNA is an emerging regulatory mechanism. Examples include Arg transfer in eukaryotes, Leu/Phe transfer in bacteria, and tRNA-synthetase-mediated addition of a
Externí odkaz:
https://doaj.org/article/a910c4670a544405a6ed75bf7af0e5f4
Publikováno v:
Frontiers in Genetics, Vol 9 (2019)
Although the genetic code is degenerate, synonymous codons for the same amino acid are not translated equally. Codon-specific translation is important for controlling gene expression and determining the proteome of a cell. At the molecular level, cod
Externí odkaz:
https://doaj.org/article/c3dbdbba3d2e40b1a873f9168893d86c
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629413
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd28e16cca08cc88b28af589f4ca44cd
https://doi.org/10.1007/978-1-0716-2942-0_13
https://doi.org/10.1007/978-1-0716-2942-0_13