Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Howard G. Shertzer"'
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 448 (2023)
Reduced glutathione (GSH) and ascorbic acid (AA) are the two most abundant low-molecular-weight antioxidants in mammalian tissues. GclmKO knockout mice lack the gene encoding the modifier subunit of the rate-limiting enzyme in GSH biosynthesis; GclmK
Externí odkaz:
https://doaj.org/article/d6af2bc325434510b49fe025256642d0
Induction of Oxidative Stress Responses by Dioxin and other Ligands of the Aryl Hydrocarbon Receptor
Publikováno v:
Dose-Response, Vol 3 (2005)
TCDD and other polyhalogenated aromatic hydrocarbon ligands of the aryl hydrocarbon receptor (AHR) have been classically considered as non-genotoxic compounds because they fail to be directly mutagenic in either bacteria or most in vitro assay system
Externí odkaz:
https://doaj.org/article/821c8d5936e7482db80a2e40cd47ab41
Autor:
Heidi Hsieh, Howard G. Shertzer, George S. Deepe, Mary Beth Genter, Kavitha Subramanian Vignesh, Divaker Choubey
Publikováno v:
Toxicology in Vitro. 35:24-30
Zinc is both an essential and potentially toxic metal. It is widely believed that oral zinc supplementation can reduce the effects of the common cold; however, there is strong clinical evidence that intranasal (IN) zinc gluconate (ZG) gel treatment f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2da2aacfec5833418ddd909ceb03aa
https://doi.org/10.1016/j.tiv.2016.05.003
https://doi.org/10.1016/j.tiv.2016.05.003
Autor:
Daniel W. Nebert, Howard G. Shertzer, Ying Chen, Vasilis Vasiliou, Hongbin Dong, David C. Thompson
Publikováno v:
Food and Chemical Toxicology. 60:38-44
Glutathione (GSH) is the most abundant cellular thiol antioxidant and it exhibits numerous and versatile functions. Disturbances in GSH homeostasis have been associated with liver diseases induced by drugs, alcohol, diet and environmental pollutants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e8f90b47a9edde659864555b0df1bd
https://doi.org/10.1016/j.fct.2013.07.008
https://doi.org/10.1016/j.fct.2013.07.008
Publikováno v:
Neuroscience Letters. 548:159-164
In humans and experimental animals, protein-enriched diets are beneficial for weight management, muscle development, managing early-stage insulin resistance and overall health. Previous studies have shown that in mice consuming a high fat diet, whey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4034a023653a942caa162d556b613c
https://doi.org/10.1016/j.neulet.2013.05.061
https://doi.org/10.1016/j.neulet.2013.05.061
Autor:
Howard G. Shertzer, Frank J. Gonzalez, Mary Beth Genter, Hongbin Dong, Daniel W. Nebert, Vasilis Vasiliou, Colin R. Jefcoate
Publikováno v:
Biochemical and Biophysical Research Communications. 435:727-732
Four dioxin-inducible enzymes––NAD(P)H: quinone oxidoreductase-1 (NQO1) and three cytochromes P450 (CYP1A1, CYP1A2 & CYP1B1)––are implicated in both detoxication and metabolic activation of various endobiotics and xenobiotics. NQO1 is general
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9eca9529c0fd190b309c9ff77c0dfa
https://doi.org/10.1016/j.bbrc.2013.05.051
https://doi.org/10.1016/j.bbrc.2013.05.051
Publikováno v:
Toxicologic Pathology. 40:1004-1013
Previous work indicates that silver nanoparticles (AgNPs) given IP to mice alter the regulation of inflammation- and oxidative stress–related genes in brain. Here we assessed the distribution and toxic potential of AgNP following intranasal (IN) ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6dce9bd5827878b01808eea2f07190
https://doi.org/10.1177/0192623312444470
https://doi.org/10.1177/0192623312444470
Exercise is an inexpensive intervention that may be used to reduce obesity and its consequences. In addition, many individuals who regularly exercise utilize dietary supplements to enhance their exercise routine and to accelerate fat loss or increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7440ce0f186920f94dc4935df867d6
https://europepmc.org/articles/PMC4788571/
https://europepmc.org/articles/PMC4788571/
Autor:
Scott N. Schneider, Mary Beth Genter, Howard G. Shertzer, Eric L. Kendig, Daniel W. Nebert, Ying Chen, Mansi Krishan, Elisabet Johansson
Publikováno v:
Toxicology and Applied Pharmacology. 257:338-348
In humans and experimental animals, high fat diets (HFD) are associated with risk factors for metabolic diseases, such as excessive weight gain and adiposity, insulin resistance and fatty liver. Mice lacking the glutamate-cysteine ligase modifier sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700df2d9b795a9bca9bfb8f107700e3f
https://doi.org/10.1016/j.taap.2011.09.017
https://doi.org/10.1016/j.taap.2011.09.017
Autor:
Charles D. Hébert, J. Gregory Hixon, Deborah M. Proctor, Howard G. Shertzer, Chad M. Thompson, Mina Suh, Mark A. Harris, Jill F. Mann, Laurie C. Haws
Publikováno v:
Toxicological Sciences
Exposure to high concentrations of hexavalent chromium (Cr[VI]) in drinking water is reported to induce oral mucosa tumors in F344 rats and intestinal tumors in B6C3F1 mice. To investigate the modes of action underlying these tumors, 90-day drinking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e2969f4105c66ef99f8855276a973a
https://doi.org/10.1093/toxsci/kfr280
https://doi.org/10.1093/toxsci/kfr280