Syndecan-1 Promotes Streptococcus pneumoniae Corneal Infection by Facilitating the Assembly of Adhesive Fibronectin Fibrils

Autor: Akiko Jinno, Atsuko Hayashida, Howard F. Jenkinson, Pyong Woo Park

Publikováno v: mBio, Vol 11, Iss 6 (2020)

ABSTRACT Subversion of heparan sulfate proteoglycans (HSPGs) is thought to be a common virulence mechanism shared by many microbial pathogens. The prevailing assumption is that pathogens co-opt HSPGs as cell surface attachment receptors or as inhibit

Externí odkaz: https://doaj.org/article/28f383a3db294b18b5ef0846687a0eb3

Community Development between Porphyromonas gingivalis and Candida albicans Mediated by InlJ and Als3

Autor: Maryta N. Sztukowska, Lindsay C. Dutton, Christopher Delaney, Mark Ramsdale, Gordon Ramage, Howard F. Jenkinson, Angela H. Nobbs, Richard J. Lamont

Publikováno v: mBio, Vol 9, Iss 2 (2018)

ABSTRACT The pleiomorphic yeast Candida albicans is a significant pathogen in immunocompromised individuals. In the oral cavity, C. albicans is an inhabitant of polymicrobial communities, and interspecies interactions promote hyphal formation and bio

Externí odkaz: https://doaj.org/article/3b174a1b9ca04901aa06082256bb7c14

O-Mannosylation in Candida albicans Enables Development of Interkingdom Biofilm Communities

Autor: Lindsay C. Dutton, Angela H. Nobbs, Katy Jepson, Mark A. Jepson, M. Margaret Vickerman, Sami Aqeel Alawfi, Carol A. Munro, Richard J. Lamont, Howard F. Jenkinson

Publikováno v: mBio, Vol 5, Iss 2 (2014)

ABSTRACT Candida albicans is a fungus that colonizes oral cavity surfaces, the gut, and the genital tract. Streptococcus gordonii is a ubiquitous oral bacterium that has been shown to form biofilm communities with C. albicans. Formation of dual-speci

Externí odkaz: https://doaj.org/article/07c4261ac2b84ba6b459a69cc1ff14e4

The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis.

Autor: Liwen Deng, Brady L Spencer, Joshua A Holmes, Rong Mu, Sara Rego, Thomas A Weston, Yoonsung Hu, Glenda F Sanches, Sunghyun Yoon, Nogi Park, Prescilla E Nagao, Howard F Jenkinson, Justin A Thornton, Keun Seok Seo, Angela H Nobbs, Kelly S Doran

Publikováno v: PLoS Pathogens, Vol 15, Iss 6, p e1007848 (2019)

Streptococcus agalactiae (Group B Streptococcus, GBS) normally colonizes healthy adults but can cause invasive disease, such as meningitis, in the newborn. To gain access to the central nervous system, GBS must interact with and penetrate brain or me

Externí odkaz: https://doaj.org/article/0539ea77d9a54a8db734d9c4912cd18d

The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture

Autor: Viren V. Patel, Victoria A. Higman, Catherine R. Back, Angela H. Nobbs, Howard F. Jenkinson, Daniel Frankel, Steven G. Burston, Alice E. Parnell, Paul R. Race, Kristian Le Vay, Matthew P. Crump

Publikováno v: Back, C, Higman, V A, Le Vay, K, Patel, V V, Parnell, A E, Frankel, D, Jenkinson, H F, Burston, S G, Crump, M P, Nobbs, A H & Race, P R 2020, ' The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture ', Journal of Biological Chemistry . https://doi.org/10.1074/jbc.RA119.011719
J Biol Chem

The cell surfaces of many bacteria carry filamentous polypeptides termed adhesins that enable binding to both biotic and abiotic surfaces. Surface adherence is facilitated by the exquisite selectivity of the adhesins for their cognate ligands or rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc9c7266182f5b50a383df6f547d704
https://doi.org/10.1074/jbc.ra119.011719