Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Howard E, Morton"'
Autor:
Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007159 (2019)
There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substanti
Externí odkaz:
https://doaj.org/article/68bed1add1a349b9b6bff6345f18be14
Autor:
Sabine Specht, Thomas W. von Geldern, Kelly L. Johnston, Franziska Lenz, Samuel Wanji, Joseph D. Turner, Nicolas Pionnier, Abdel Jelil Njouendou, Dominique Bloemker, Darren A. N. Cook, Robert A. Carr, Louise Ford, Stephen A. Ward, Mark J. Taylor, Kennan C. Marsh, Marianne Koschel, Hanna T. Sjoberg, Howard E. Morton, Dale J. Kempf, John Archer, Hayley E. Tyrer, Haelly M. Metuge, Fanny Fri Fombad, Ghaith Aljayyoussi, Valerinne C. Chunda, Patrick W. N. Chounna, Rachel H. Clare, Marc P. Hübner, Alexandra Ehrens, Achim Hoerauf, Andrew Steven, Emma A Murphy
Publikováno v:
Science Translational Medicine. 11(483)
There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide veterinary antibiotic, tylosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bf4e4e87aab96ab422a6006d9f9f80
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Mark J, Taylor, Thomas W, von Geldern, Louise, Ford, Marc P, Hübner, Kennan, Marsh, Kelly L, Johnston, Hanna T, Sjoberg, Sabine, Specht, Nicolas, Pionnier, Hayley E, Tyrer, Rachel H, Clare, Darren A N, Cook, Emma, Murphy, Andrew, Steven, John, Archer, Dominique, Bloemker, Franziska, Lenz, Marianne, Koschel, Alexandra, Ehrens, Haelly M, Metuge, Valerinne C, Chunda, Patrick W, Ndongmo Chounna, Abdel J, Njouendou, Fanny F, Fombad, Robert, Carr, Howard E, Morton, Ghaith, Aljayyoussi, Achim, Hoerauf, Samuel, Wanji, Dale J, Kempf, Joseph D, Turner, Stephen A, Ward
Publikováno v:
Science translational medicine. 11(483)
There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide veterinary antibiotic, tylosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb5aec0eeb0a980ff0eb7b36977cb89d
https://pubmed.ncbi.nlm.nih.gov/30867321
https://pubmed.ncbi.nlm.nih.gov/30867321
Publikováno v:
Tetrahedron Letters. 48:1059-1062
ABT-578, an anti-restenosis agent exists as two isomers, a major pyran form and a minor oxepane form. The existence of the two isomeric forms was established by isolation and equilibration studies under buffered and physiological conditions. Finally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc2829b679e225ca964482b621ba5c4b
https://doi.org/10.1016/j.tetlet.2006.11.157
https://doi.org/10.1016/j.tetlet.2006.11.157
Autor:
John E. Lallaman, Jianguo Ji, Wenke Li, Howard E. Morton, Ji Zhang, Francis A. J. Kerdesky, M. Robert Leanna
Publikováno v:
Organic Process Research & Development. 10:512-517
An efficient chemical process for the multikilogram synthesis of ABT-963 (3) is described. The potent and selective COX-2 inhibitor was prepared in four steps in 36% overall isolated yield from commercially available 3,4-difluoroaniline (4). The chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::337a8c24dfdafd064fcba98fe007c78e
https://doi.org/10.1021/op060016v
https://doi.org/10.1021/op060016v
Autor:
Gregory S. Wayne, John E. Lallaman, Lakshmi Bhagavatula, Jonathan P. Pease, Ramiya H. Premchandran, Steven A. King, William H. Arnold, Francis A. J. Kerdesky, Howard E. Morton, Sou-Jen Chang
Publikováno v:
Organic Process Research & Development. 6:869-875
An efficient and practical synthesis of 2‘-O-benzoyl-3-keto-6-O-propargyl-11,12-carbamoyl erythromycin A (4) is described. The semisynthetic macrolide was prepared on large scale in seven steps in 38% overall isolated yield from the readily availab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b69503992080c905ff0b708a26f8db0a
https://doi.org/10.1021/op025535m
https://doi.org/10.1021/op025535m
Autor:
Seble Wagaw, Jianguo Ji, Michael A Fitzgerald, Michael G. Fickes, David M. Barnes, Frederick A. Plagge, Margo Preskill, Steven A. King, Steven J. Wittenberger, Ji Zhang, Howard E. Morton
Publikováno v:
Journal of the American Chemical Society. 124:13097-13105
The enantioselective synthesis of endothelin-A antagonist ABT-546 has been accomplished via the discovery and development of a highly selective catalytic asymmetric conjugate addition of ketoesters to nitroolefins. Employing just 4 mol % bis(oxazolin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fd40e87e9cded6c7ab9ee255e355fa
https://doi.org/10.1021/ja026788y
https://doi.org/10.1021/ja026788y
Autor:
William A. Arnold, Lynch John K, Mark W. Holladay, Keith B. Ryther, Daniel A. Dickman, Chi-Nung Hsiao, Hao Bai, Howard E. Morton, Steven A. King
Publikováno v:
Tetrahedron: Asymmetry. 9:2791-2794
A concise asymmetric synthesis of ( R )-2-chloro-5-(2-azetidinylmethoxy)pyridine (ABT-594) is presented in which the key intermediate t -butoxycarbonyl protected (2 R )-azetidinylalcohol is obtained in three steps from the dibenzyl ester of D-asparti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::809f7c36d2b29e2bee41ae748ec73418
https://doi.org/10.1016/s0957-4166(98)00291-2
https://doi.org/10.1016/s0957-4166(98)00291-2
Autor:
Thomas Albert, Sanjay R. Chemburkar, Howard E. Morton, Daniel A. Dickman, David P. Sawick, Daniel J. Plata, Hemantkumar H. Patel, Yi-Yin Ku
Publikováno v:
Tetrahedron: Asymmetry. 8:1791-1795
A convergent, high yielding, and scalable synthesis of A-79175, with a key step involving a mild and efficient CuPd catalyzed coupling reaction of a terminal acetylene with a substituted 2-iodofuran is discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d426cb36c5594711d119e9586cef353
https://doi.org/10.1016/s0957-4166(97)00159-6
https://doi.org/10.1016/s0957-4166(97)00159-6
Autor:
Mike Rozema, Padam Sharma, Tim Grieme, Yi-Yin Ku, Howard E. Morton, Prasad S. Raje, Steve A. King
Publikováno v:
The Journal of Organic Chemistry. 68:3238-3240
A practical and scaleable synthesis of a novel nonsteroidal ligand for the glucocorticoid receptor A-224817.0 1A is described. The synthesis proceeds in seven steps starting from 1,3-dimethoxybenzene. The biaryl intermediate 5 was prepared by an opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c48ac204a4875d3c7f0e19021039be
https://doi.org/10.1021/jo0268613
https://doi.org/10.1021/jo0268613