Zobrazeno 1 - 10
of 554
pro vyhledávání: '"Howard E, Gendelman"'
Autor:
Farhana Islam, Srijanee Das, Md Ashaduzzaman, Brady Sillman, Pravin Yeapuri, Mohammad Ullah Nayan, David Oupický, Howard E. Gendelman, Bhavesh D. Kevadiya
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract An extended action fostemsavir (FTR) lipid nanoparticle (LNP) formulation prevents human immunodeficiency virus type one (HIV-1) infection. This FTR formulation establishes a drug depot in monocyte-derived macrophages that extend the drug’
Externí odkaz:
https://doaj.org/article/724d71a1580b4ef987734da42550c3e9
Autor:
Pravin Yeapuri, Jatin Machhi, Yaman Lu, Mai Mohamed Abdelmoaty, Rana Kadry, Milankumar Patel, Shaurav Bhattarai, Eugene Lu, Krista L. Namminga, Katherine E. Olson, Emma G. Foster, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background Regulatory T cells (Tregs) maintain immune tolerance. While Treg-mediated neuroprotective activities are now well-accepted, the lack of defined antigen specificity limits their therapeutic potential. This is notable for neurodegen
Externí odkaz:
https://doaj.org/article/e41efd3b0d7a4a99bcf11d2d1852d2b7
Autor:
Mai M. Abdelmoaty, Eugene Lu, Rana Kadry, Emma G. Foster, Shaurav Bhattarai, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-23 (2023)
Abstract Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic aggregates of neural and glial α-synuclein (α-syn) in the form of Lewy bodies (LBs), Lewy neurites, and cytoplasmic inclusions in both neurons and gli
Externí odkaz:
https://doaj.org/article/2c505cc77c0f419ab35ba80333b7b3fd
Autor:
Emma G. Foster, Brady Sillman, Yutong Liu, Micah Summerlin, Vikas Kumar, Balasrinivasa R. Sajja, Adam R. Cassidy, Benson Edagwa, Howard E. Gendelman, Aditya N. Bade
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The World Health Organization has recommended dolutegravir (DTG) as a preferred first-line treatment for treatment naive and experienced people living with human immunodeficiency virus type one (PLWHIV). Based on these recommendations 15 million PLWH
Externí odkaz:
https://doaj.org/article/ba6d4ed836814c72aee66959707f131a
Autor:
Katherine E. Olson, Mai M. Abdelmoaty, Krista L. Namminga, Yaman Lu, Helen Obaro, Pamela Santamaria, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-17 (2023)
Abstract Background The clinical utility and safety of sargramostim has previously been reported in cancer, acute radiation syndrome, autoimmune disease, inflammatory conditions, and Alzheimer’s disease. The safety, tolerability, and mechanisms of
Externí odkaz:
https://doaj.org/article/6aff7aaecbfb4f87a699e0984d9801ed
Autor:
Chen Zhang, Hang Su, Emiko Waight, Larisa Y. Poluektova, Santhi Gorantla, Howard E. Gendelman, Prasanta K. Dash
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 149 (2024)
Disordered immunity, aging, human immunodeficiency virus type one (HIV-1) infection, and responses to antiretroviral therapy are linked. However, how each factor is linked with the other(s) remains incompletely understood. It has been reported that a
Externí odkaz:
https://doaj.org/article/969744862a8b47bf8345d2a165db9cb3
Autor:
Mohammad Ullah Nayan, Sudipta Panja, Ashrafi Sultana, Lubaba A. Zaman, Lalitkumar K. Vora, Brady Sillman, Howard E. Gendelman, Benson Edagwa
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 183 (2024)
The success of long-acting (LA) drug delivery systems (DDSs) is linked to their biocompatible polymers. These are used for extended therapeutic release. For treatment or prevention of human immune deficiency virus type one (HIV-1) infection, LA DDSs
Externí odkaz:
https://doaj.org/article/801fbe43738b4fdabac519e7aedc77ff
Autor:
Suyash Deodhar, Brady Sillman, Aditya N. Bade, Sean N. Avedissian, Anthony T. Podany, JoEllyn M. McMillan, Nagsen Gautam, Brandon Hanson, Bhagya L. Dyavar Shetty, Adam Szlachetka, Morgan Johnston, Michellie Thurman, Daniel J. Munt, Alekha K. Dash, Milica Markovic, Arik Dahan, Yazen Alnouti, Alborz Yazdi, Bhavesh D. Kevadiya, Siddappa N. Byrareddy, Samuel M. Cohen, Benson Edagwa, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, using animal models, Deodhar et al. single parenteral dose of dolutegravir (DTG) prodrug nanocrystals sustains drug protein-adjusted 90% inhibitory concentration for up to a year, without injection site reactions or systemic toxicities.
Externí odkaz:
https://doaj.org/article/0e6c6ddce7834d67b915c46f752da67f
Autor:
Emma G. Foster, Nicholas Y. Palermo, Yutong Liu, Benson Edagwa, Howard E. Gendelman, Aditya N. Bade
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
More than fifteen million women with the human immunodeficiency virus type-1 (HIV-1) infection are of childbearing age world-wide. Due to improved and affordable access to antiretroviral therapy (ART), the number of in utero antiretroviral drug (ARV)
Externí odkaz:
https://doaj.org/article/b9159025b308451580c072153a6e3201
Autor:
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-23 (2021)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in kind facilitates tau aggregation and neurodegeneration. Neuroinf
Externí odkaz:
https://doaj.org/article/9566142d7b6b497fa6e8c5d16550ee05