Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Howard D Lindsay"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract In response to DNA double-strand breaks or oxidative stress, ATM-dependent DNA damage response (DDR) is activated to maintain genome integrity. However, it remains elusive whether and how DNA single-strand breaks (SSBs) activate ATM. Here, w
Externí odkaz:
https://doaj.org/article/22483882e6f14e2ba45fa47524940623
Autor:
Hideo Fukuhara, Endre J. Szili, Jun-Seok Oh, Kawada Chiaki, Shinkuro Yamamoto, Atsushi Kurabayashi, Mutsuo Furihata, Masayuki Tsuda, Hiroshi Furuta, Howard D. Lindsay, Robert D. Short, Akimitsu Hatta, Keiji Inoue
Publikováno v:
Plasma, Vol 5, Iss 2, Pp 233-246 (2022)
Current methods used to treat non-muscle invasive bladder cancer are inadequate due to a high recurrence rate after surgery and the occurrence of adverse events such as interstitial pneumonia following intravesical instillation therapy. Low-temperatu
Externí odkaz:
https://doaj.org/article/edb5d4bad2094e63bd214c81c543264d
Autor:
Thomas A. Guilliam, Nigel C. Brissett, Aaron Ehlinger, Benjamin A. Keen, Peter Kolesar, Elaine M. Taylor, Laura J. Bailey, Howard D. Lindsay, Walter J. Chazin, Aidan J. Doherty
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stim
Externí odkaz:
https://doaj.org/article/6c3b35c0421a4ab2b8722df6acbdcac6
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181131 (2017)
Acting through a complex signalling network, DNA lesions trigger a range of cellular responses including DNA repair, cell cycle arrest, altered gene expression and cell death, which help to limit the mutagenic effects of such DNA damage. RNA processi
Externí odkaz:
https://doaj.org/article/62ae1f4fa9294b5384d67890ffb204a4
Autor:
Laura J. Bailey, Rebecca Teague, Aidan J. Doherty, Howard D. Lindsay, Lewis J Bainbridge, Peter Kolesar
Publikováno v:
Science Advances
Description
PrimPol is regulated by PLK1 phosphorylation to restrict repriming and prevent genomic instability.
Replication stress and DNA damage stall replication forks and impede genome synthesis. During S phase, damage tolerance pathways
PrimPol is regulated by PLK1 phosphorylation to restrict repriming and prevent genomic instability.
Replication stress and DNA damage stall replication forks and impede genome synthesis. During S phase, damage tolerance pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b966009d07a42362160b90f9e6d66ce
http://sro.sussex.ac.uk/id/eprint/103390/3/sciadv.abh1004.pdf
http://sro.sussex.ac.uk/id/eprint/103390/3/sciadv.abh1004.pdf
Autor:
Hideo Fukuhara, Endre J. Szili, Jun-Seok Oh, Kawada Chiaki, Shinkuro Yamamoto, Atsushi Kurabayashi, Mutsuo Furihata, Masayuki Tsuda, Hiroshi Furuta, Howard D. Lindsay, Robert D. Short, Akimitsu Hatta, Keiji Inoue
Current methods used to treat non-muscle invasive bladder cancer are inadequate due to a high recurrence rate after surgery and occurrence of adverse events such as interstitial pneumonia following intravesical instillation therapy. Low-temperature p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1507ed190aadf151080a75f22b90e2
https://doi.org/10.21203/rs.3.rs-701484/v1
https://doi.org/10.21203/rs.3.rs-701484/v1
Autor:
Howard D. Lindsay, Andrew J. Green, Irena Stevanovic, Aidan J. Doherty, Sean G. Rudd, Elaine M. Taylor, Julie Bianchi, Laura J. Bailey, Stanislaw K. Jozwiakowski, Violetta Soura, Travis H. Stracker
Publikováno v:
Molecular Cell
Summary DNA damage can stall the DNA replication machinery, leading to genomic instability. Thus, numerous mechanisms exist to complete genome duplication in the absence of a pristine DNA template, but identification of the enzymes involved remains i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649b7cf1541118688f0730b3f0c83aa9
https://doi.org/10.1016/j.molcel.2013.10.035
https://doi.org/10.1016/j.molcel.2013.10.035
Publikováno v:
Nucleic Acids Research
UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) has a well-established role in epigenetic regulation through the recognition of various histone marks and interaction with chromatin-modifying proteins. However, its function in regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848381ba2048a5e43899b5a401b099bd
http://europepmc.org/articles/PMC3763540
http://europepmc.org/articles/PMC3763540
Autor:
Thomas A, Guilliam, Nigel C, Brissett, Aaron, Ehlinger, Benjamin A, Keen, Peter, Kolesar, Elaine M, Taylor, Laura J, Bailey, Howard D, Lindsay, Walter J, Chazin, Aidan J, Doherty
Publikováno v:
Nature Communications
DNA damage and secondary structures can stall the replication machinery. Cells possess numerous tolerance mechanisms to complete genome duplication in the presence of such impediments. In addition to translesion synthesis (TLS) polymerases, most euka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::063ecee0150004eabcb25edd4d553162
https://pubmed.ncbi.nlm.nih.gov/28534480
https://pubmed.ncbi.nlm.nih.gov/28534480
Autor:
Elaine M. Taylor, Howard D. Lindsay
Publikováno v:
Future oncology (London, England). 12(2)
There is an extensive and growing body of evidence that DNA replication stress is a major driver in the development and progression of many cancers, and that these cancers rely heavily on replication stress response pathways for their continued proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379831a4984d18f4d56df5bd8c176ce4
https://pubmed.ncbi.nlm.nih.gov/26616915
https://pubmed.ncbi.nlm.nih.gov/26616915