Recombinant fragment of human surfactant protein D to prevent neonatal chronic lung disease (RESPONSE): a protocol for a phase I safety trial in a tertiary neonatal unit

Autor: Neil Marlow, Hakim-Moulay Dehbi, Howard Clark, Reena Bhatt, Kathy Chant, Jens Madsen, Tania Castillo-Hernandez

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Introduction Chronic respiratory morbidity from bronchopulmonary dysplasia (BPD) remains the most common complication of preterm birth and has consequences for later respiratory, cardiovascular and neurodevelopmental outcomes. The early phases of res

Externí odkaz: https://doaj.org/article/4a409b4658ad4e3c84614bfb76defc97

Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines.

Autor: Shanta Boddapati, Jason Gilmore, Kyle Boone, John Bushey, Jonathan Ross, Brian Gfeller, William McFee, Romesh Rao, Greg Corrigan, Aaron Chen, Howard Clarke, John Valliere-Douglass, Swapnil Bhargava

Publikováno v: PLoS ONE, Vol 15, Iss 10, p e0241250 (2020)

With the advent of highly sensitive technologies such as tandem mass spectrometry and next-generation sequencing, recombinant antibodies are now routinely analyzed for the presence of low-level sequence variants including amino acid misincorporations

Externí odkaz: https://doaj.org/article/93f2112737fa47e88620bc8d55e07876

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Prebiotic proanthocyanidins inhibit bile reflux-induced esophageal adenocarcinoma through reshaping the gut microbiome and esophageal metabolome.

Autor: Weh KM; Department of Surgery, Section of Thoracic Surgery, and.; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA., Howard CL; Department of Surgery, Section of Thoracic Surgery, and.; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA., Zhang Y; Department of Surgery, Section of Thoracic Surgery, and.; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA., Tripp BA; Department of Electrical and Computer Engineering, and., Clarke JL; Department of Statistics, Department of Food Science Technology, Quantitative Life Sciences Initiative, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Howell AB; Marucci Center for Blueberry and Cranberry Research, Rutgers University, Chatsworth, New Jersey, USA., Rubenstein JH; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; LTC Charles S. Kettles Veterans Affairs Medical Center, Ann Arbor, Michigan, USA., Abrams JA; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Westerhoff M; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Kresty LA; Department of Surgery, Section of Thoracic Surgery, and.; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Feb 08; Vol. 9 (6). Date of Electronic Publication: 2024 Feb 08.