Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Howard C. Haspel"'
Publikováno v:
Journal of Nuclear Cardiology. 10:385-394
In patients with hibernating myocardium, regional uptake of the glucose analog 2-fluorine 18-fluoro-2-deoxy-d-glucose (FDG) is increased under resting conditions. It is unclear whether the degree of increased FDG uptake correlates with the degree of
Publikováno v:
Microvascular Research. 63:304-315
The angiogenic vascular endothelial growth factor (VEGF) is believed to play a critical role in endothelial cell proliferation, differentiation, and sprouting. Small molecules that selectively inhibit the VEGF receptor-associated tyrosine kinase acti
Autor:
Richard L. Croxen, Aida El-Barbary, Joseph D. Fenstermacher, Howard C. Haspel, Keli N Stephenson
Publikováno v:
Biochemical Pharmacology. 60:651-659
Ketamine, etomidate, propofol, and pentobarbital were compared for effects on and interactions with the type 1 facilitative glucose transporter (GLUT-1). Fluxes of radiolabeled hexoses were used to determine the effects of anesthetics on GLUT-1 funct
Publikováno v:
Biochemistry. 35:15222-15227
Barbiturates inhibit GLUT-1 mediated hexose transport both in vivo [Gjedde & Rasmussen (1980) J. Neurochem. 35, 1382-1387; Otsuka et al. (1991) Am. J. Physiol. 261, R265-R275] and in vitro [Honkanen et al. (1995) Biochemistry 34, 535-544]. In the pre
Publikováno v:
Biochemistry. 34:7703-7711
The purpose of this study was to determine the effect of increased lipid packing on the conformational states of the GLUT-1 hexose transporter purified in endogenous lipids. The binding of glucose results in a conformational change that can be follow
Publikováno v:
Biochemistry. 31:5386-5393
The nature of the membrane compartments involved in the regulation by glucose of hexose transport is not well defined. The effect of inhibitors of lysosomal protein degradation on hexose transport (i.e., uptake of [3H]-2-deoxy-D-glucose) and hexose t
Autor:
Haim Werner, Laura M. Mudd, Howard C. Haspel, Charles T. Roberts, Derek LeRoith, Mohan K. Raizada, Zila Shen-Orr
Publikováno v:
Endocrinology. 126:545-549
We have demonstrated regulation of the rat brain/Hep G2 glucose transporter gene (GT1) by Northern blot analysis with a rat brain glucose transporter cDNA probe. Incubation of both neuronal and glial cells derived from neonatal rats with 12-O-tetrade
Autor:
Mary C. Gannon, Bilal Murad, Alex J. Lange, Herbert B. Ward, Joseph Sikora, Jeih San Liow, Howard C. Haspel, Edward O. McFalls, David Marx
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 282(1)
Repetitive myocardial ischemia increases glucose uptake, but the effect on glycogen is unclear. Thirteen swine instrumented with a hydraulic occluder on the circumflex (Cx) artery underwent 10-min occlusions twice per day for 4 days. After 24 h postf
Autor:
Ian A. Simpson, Theresa Davies-Hill, Richard L. Croxen, Ellen M. Koehler-Stec, Howard C. Haspel, Aida El-Barbary, K.N. Stephenson, Joseph D. Fenstermacher, W. Mougrabi, J.F. Lobo
Publikováno v:
The Journal of membrane biology. 169(1)
Barbiturates inhibit GLUT-1-mediated glucose transport across the blood-brain barrier, in cultured mammalian cells, and in human erythrocytes. Barbiturates also interact directly with GLUT-1. The hypotheses that this inhibition of glucose transport i
Autor:
Christopher Kushmerick, Joseph D. Fenstermacher, Howard C. Haspel, Gordon E. Callender, Robert A. Honkanen, Suzanne Scarlata, Heather McBath
Publikováno v:
Biochemistry. 34(2)
Barbiturates reduce cerebral blood flow, metabolism, and Glc transfer across the blood-brain barrier. The effect of barbiturates on hexose transport in cultured mammalian cell lines and human erythrocytes was studied. Pentobarbital inhibits [3H]-2-dG