Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Howard C. H. Kuo"'
Autor:
Prasun K. Chakravarty, Steven L. Colletti, Howard C. H. Kuo, Christine Snedden, Michelle B. Ayer, L.M. Gregory, Michael H. Fisher, Wesley L. Shoop, Matthew J. Wyvratt, Michelle Zakson-Aiken, Peter T. Meinke, Thomas L. Shih, Dennis M. Schmatz, Sriram Tyagarajan
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(1)
Efficient routes to access the 2", 3", 4", and 6" registers of the nodulisporic acid (NsA) side chain are disclosed. A mild one-carbon, Ph(2)CdoublebondNCH(2)CtriplebondN mediated homologation of NsA's 3"-aldehyde permitted access to the 4"-register.
Autor:
D. Euan MacIntyre, Xiaoxia Qian, Dennis Feng, Michael J. Forrest, Vincent J. Colandrea, Michael H. Fisher, Ralph A. Stearns, Ann E. Weber, Howard C. H. Kuo, Matthew J. Wyvratt, Catherine D. Strader, Gui-Bai Liang, Lawrence F. Colwell, Margaret A. Cascieri, Mari R. Candelore, Gary J Hom, Tesfaye Biftu, Elizabeth M. Naylor
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(13)
Benzyl and phenoxymethylene substituted oxadiazoles are potent and orally bioavailable beta3 adrenergic receptor (AR) agonists. The 4-trifluormethoxy substituted 5-benzyl oxadiazole 5f has an EC50 of 8 nM in the beta3 AR agonist assay with 100-fold s