Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Howard B Cottam"'
Autor:
Tomoko Hayashi, Shiyin Yao, Brian Crain, Victor J Promessi, Luke Shyu, Caroline Sheng, McNancy Kang, Howard B Cottam, Dennis A Carson, Maripat Corr
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129867 (2015)
Autoimmune diabetes mellitus (DM) results from the destruction of pancreatic islet cells by activated T lymphocytes, which have been primed by activated dendritic cells (DC). Individualized therapy with ex vivo DC manipulation and reinfusion has been
Externí odkaz:
https://doaj.org/article/a0deb4f5bc424838a90918bde039bbae
Autor:
Tomoko Hayashi, Shiyin Yao, Brian Crain, Michael Chan, Rommel I Tawatao, Christine Gray, Linda Vuong, Fitzgerald Lao, Howard B Cottam, Dennis A Carson, Maripat Corr
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45860 (2012)
The Toll-like receptors (TLR) have been advocated as attractive therapeutic targets because TLR signaling plays dual roles in initiating adaptive immune responses and perpetuating inflammation. Paradoxically, repeated stimulation of bone marrow monon
Externí odkaz:
https://doaj.org/article/16ff2ba27a834476b5bee9d24d27d199
Autor:
Donald F Smee, Howard B Cottam, Brahma S Sharma, Ganesh D Kini, Ganapathi R Revankar, Emmanuel A Ojo-Amaize, Robert W Sidwell, Weldon B Jolley, Roland K Robins
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 3, Iss Suppl B, Pp 41-48 (1992)
7-thia-8-oxoguanosine (TOGuo) is the first reported structure of a family of modified guanosine analogues exhibiting antiviral activity in rodent models. Its spectrum of action includes interferon-sensitive viruses such as alphaviruses, bunyaviruses,
Externí odkaz:
https://doaj.org/article/c4c9e5228dba4f8a9eceddc11c64aceb
Autor:
Walid M. Abdelwahab, Sarah Auclair, Timothy Borgogna, Karthik Siram, Alexander Riffey, Hélène G. Bazin, Howard B. Cottam, Tomoko Hayashi, Jay T. Evans, David J. Burkhart
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 107 (2024)
Co-delivery of antigens and adjuvants to the same antigen-presenting cells (APCs) can significantly improve the efficacy and safety profiles of vaccines. Here, we report amine-grafted silica nanoparticles (A-SNP) as a tunable vaccine co-delivery plat
Externí odkaz:
https://doaj.org/article/26544322b0c64072a9ae66274353b9af
Autor:
Fumi Sato-Kaneko, Shiyin Yao, Fitzgerald S. Lao, Yukiya Sako, Jasmine Jin, Nikunj M. Shukla, Howard B. Cottam, Michael Chan, Masiel M. Belsuzarri, Dennis A. Carson, Tomoko Hayashi
Publikováno v:
Vaccines, Vol 10, Iss 10, p 1694 (2022)
Systemically vaccinated individuals against COVID-19 and influenza may continue to support viral replication and shedding in the upper airways, contributing to the spread of infections. Thus, a vaccine regimen that enhances mucosal immunity in the re
Externí odkaz:
https://doaj.org/article/1510fead4a854a0f8b6c927533a1d0c3
Autor:
Tetsuya Saito, Yukiya Sako, Fumi Sato-Kaneko, Tadashi Hosoya, Shiyin Yao, Fitzgerald S. Lao, Jonathan Shpigelman, Karen Messer, Minya Pu, Nikunj M. Shukla, Michael Chan, Paul J. Chu, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Maripat Corr
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
As viruses continue to mutate the need for rapid high titer neutralizing antibody responses has been highlighted. To meet these emerging threats, agents that enhance vaccine adjuvant activity are needed that are safe with minimal local or systemic si
Externí odkaz:
https://doaj.org/article/d83813520f2f4354bec7ef48dd7c4b12
Autor:
Yukiya Sako, Fumi Sato-Kaneko, Nikunj M. Shukla, Shiyin Yao, Masiel M. Belsuzarri, Michael Chan, Tetsuya Saito, Fitzgerald S. Lao, Helen Kong, Marina Puffer, Karen Messer, Minya Pu, Howard B. Cottam, Dennis A. Carson, Tomoko Hayashi
Publikováno v:
ACS Chemical Biology. 18:982-993
Autor:
Jonathan Shpigelman, Fitzgerald S. Lao, Shiyin Yao, Chenyang Li, Tetsuya Saito, Fumi Sato-Kaneko, John P. Nolan, Nikunj M. Shukla, Minya Pu, Karen Messer, Howard B. Cottam, Dennis A. Carson, Maripat Corr, Tomoko Hayashi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Extracellular vesicles (EVs) are identified as mediators of intercellular communication and cellular regulation. In the immune system, EVs play a role in antigen presentation as a part of cellular communication. To enable drug discovery and character
Externí odkaz:
https://doaj.org/article/d0e94b9e76c844fa84d4408726cbf8d3
Autor:
Tadashi Hosoya, Nikunj M. Shukla, Yuya Fujita, Shiyin Yao, Fitzgerald S. Lao, Hiroyuki Baba, Shinsuke Yasuda, Howard B. Cottam, Dennis A. Carson, Tomoko Hayashi, Maripat Corr
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
In recent years target based drug discovery has expanded our therapeutic armamentarium in the treatment of inflammatory and autoimmune diseases. Despite these advances and adverse effects, glucocorticoids remain reliable agents that are used in many
Externí odkaz:
https://doaj.org/article/d6169ac487954c14abde62e44e41f4b5