Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Howard B Cottam"'
Autor:
Walid M. Abdelwahab, Sarah Auclair, Timothy Borgogna, Karthik Siram, Alexander Riffey, Hélène G. Bazin, Howard B. Cottam, Tomoko Hayashi, Jay T. Evans, David J. Burkhart
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 107 (2024)
Co-delivery of antigens and adjuvants to the same antigen-presenting cells (APCs) can significantly improve the efficacy and safety profiles of vaccines. Here, we report amine-grafted silica nanoparticles (A-SNP) as a tunable vaccine co-delivery plat
Externí odkaz:
https://doaj.org/article/26544322b0c64072a9ae66274353b9af
Autor:
Nikunj M. Shukla, Fumi Sato-Kaneko, Shiyin Yao, Minya Pu, Michael Chan, Fitzgerald S. Lao, Yukiya Sako, Tetsuya Saito, Karen Messer, Tomoko Hayashi, Howard B. Cottam, Maripat Corr, Dennis A. Carson
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Extracellular vesicles (EVs) play an important role in intercellular communication and regulation of cells, especially in the immune system where EVs can participate in antigen presentation and may have adjuvant effects. We aimed to identify small mo
Externí odkaz:
https://doaj.org/article/3a3178cd4fc742ca9336319813e6c610
Autor:
Fumi Sato-Kaneko, Shiyin Yao, Fitzgerald S. Lao, Yukiya Sako, Jasmine Jin, Nikunj M. Shukla, Howard B. Cottam, Michael Chan, Masiel M. Belsuzarri, Dennis A. Carson, Tomoko Hayashi
Publikováno v:
Vaccines, Vol 10, Iss 10, p 1694 (2022)
Systemically vaccinated individuals against COVID-19 and influenza may continue to support viral replication and shedding in the upper airways, contributing to the spread of infections. Thus, a vaccine regimen that enhances mucosal immunity in the re
Externí odkaz:
https://doaj.org/article/1510fead4a854a0f8b6c927533a1d0c3
Autor:
Tetsuya Saito, Yukiya Sako, Fumi Sato-Kaneko, Tadashi Hosoya, Shiyin Yao, Fitzgerald S. Lao, Jonathan Shpigelman, Karen Messer, Minya Pu, Nikunj M. Shukla, Michael Chan, Paul J. Chu, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Maripat Corr
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
As viruses continue to mutate the need for rapid high titer neutralizing antibody responses has been highlighted. To meet these emerging threats, agents that enhance vaccine adjuvant activity are needed that are safe with minimal local or systemic si
Externí odkaz:
https://doaj.org/article/d83813520f2f4354bec7ef48dd7c4b12
Autor:
Yukiya Sako, Fumi Sato-Kaneko, Nikunj M. Shukla, Shiyin Yao, Masiel M. Belsuzarri, Michael Chan, Tetsuya Saito, Fitzgerald S. Lao, Helen Kong, Marina Puffer, Karen Messer, Minya Pu, Howard B. Cottam, Dennis A. Carson, Tomoko Hayashi
Publikováno v:
ACS Chemical Biology. 18:982-993
Autor:
Jonathan Shpigelman, Fitzgerald S. Lao, Shiyin Yao, Chenyang Li, Tetsuya Saito, Fumi Sato-Kaneko, John P. Nolan, Nikunj M. Shukla, Minya Pu, Karen Messer, Howard B. Cottam, Dennis A. Carson, Maripat Corr, Tomoko Hayashi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Extracellular vesicles (EVs) are identified as mediators of intercellular communication and cellular regulation. In the immune system, EVs play a role in antigen presentation as a part of cellular communication. To enable drug discovery and character
Externí odkaz:
https://doaj.org/article/d0e94b9e76c844fa84d4408726cbf8d3
Autor:
Tadashi Hosoya, Nikunj M. Shukla, Yuya Fujita, Shiyin Yao, Fitzgerald S. Lao, Hiroyuki Baba, Shinsuke Yasuda, Howard B. Cottam, Dennis A. Carson, Tomoko Hayashi, Maripat Corr
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
In recent years target based drug discovery has expanded our therapeutic armamentarium in the treatment of inflammatory and autoimmune diseases. Despite these advances and adverse effects, glucocorticoids remain reliable agents that are used in many
Externí odkaz:
https://doaj.org/article/d6169ac487954c14abde62e44e41f4b5
Autor:
Howard B. Cottam, Masaharu Yuki, Masahiro Wakao, Dennis A. Carson, Mayumi Niimura, Takayoshi Yamauchi, Tomoko Hayashi, Toshiro Moroishi, Yasuo Suda, Hiroyuki Shinchi
Publikováno v:
ACS Applied Bio Materials. 4:2732-2741
Toll-like receptors (TLRs) are pattern recognition receptors that activate innate immunity, and their ligands are promising adjuvants for vaccines and immunotherapies. Small molecule TLR7 ligands are ideal vaccine adjuvants as they induce not only pr
Autor:
Tetsuya Saito, Nikunj M. Shukla, Fumi Sato-Kaneko, Yukiya Sako, Tadashi Hosoya, Shiyin Yao, Fitzgerald S. Lao, Karen Messer, Minya Pu, Michael Chan, Paul J. Chu, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Maripat Corr
Publikováno v:
ACS chemical biology. 17(1)
There remains an unmet need for reliable fully synthetic adjuvants that increase lasting protective immune responses from vaccines. We previously reported a high-throughput screening for small molecules that extended nuclear factor kappa-light-chain