Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Howard A. Nash"'
Autor:
Bridget C Lear, Eric J Darrah, Benjamin T Aldrich, Senetibeb Gebre, Robert L Scott, Howard A Nash, Ravi Allada
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78147 (2013)
In the fruit fly Drosophila melanogaster, a network of circadian pacemaker neurons drives daily rhythms in rest and activity. The ion channel NARROW ABDOMEN (NA), orthologous to the mammalian sodium leak channel NALCN, functions downstream of the mol
Externí odkaz:
https://doaj.org/article/18e1130d93ec46f0859279232e9c7e20
Publikováno v:
Proceedings of the National Academy of Sciences. 111:15816-15820
Tyrosyl-DNA phosphodiesterase (TDP1) is a phylogenetically conserved enzyme critical for the removal of blocking lesions at the 3' ends of DNA or RNA. This study analyzes the Drosophila TDP1 gene ortholog glaikit (gkt) and its possible role(s) in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36db315708d18ba7230120104fb0e0f5
https://doi.org/10.1073/pnas.1415011111
https://doi.org/10.1073/pnas.1415011111
Publikováno v:
Genes, Brain and Behavior. 12:338-347
Members of many species tend to congregate, a behavioral strategy known as local enhancement. Selective advantages of local enhancement range from efficient use of resources to defense from predators. While previous studies have examined many types o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::680063d1cc7dd6d5024f5b6aa115025c
https://doi.org/10.1111/gbb.12025
https://doi.org/10.1111/gbb.12025
Publikováno v:
Anesthesiology. 118:587-601
Background—Although in vitro studies have identified numerous possible targets, the molecules that mediate the in vivo effects of volatile anesthetics remain largely unknown. The mammalian ryanodine receptor (Ryr) is a known halothane target, and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e18d68dd694a1852e31d05c7d7f50ca
https://doi.org/10.1097/aln.0b013e31827e52c6
https://doi.org/10.1097/aln.0b013e31827e52c6
Publikováno v:
Journal of Neurogenetics. 23:412-421
Mutations that influence the sensitivity of an organism to a volatile general anesthetic can be divided into two classes. In one, sensitivity to all other volatile agents is affected to a similar degree. Although this class may contain mutations of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937fd1b08ab0c0b1352c67ead4f5ba8c
https://doi.org/10.3109/01677060903177800
https://doi.org/10.3109/01677060903177800
Autor:
Terrance P. Snutch, Kevin S. Hamming, Howard A. Nash, Phil G. Morgan, John A. Humphrey, Margaret M. Sedensky, Robert L. Scott, Colin Thacker
Publikováno v:
Current Biology. 17(7):624-629
Summary Volatile anesthetics like halothane and enflurane are of interest to clinicians and neuroscientists because of their ability to preferentially disrupt higher functions that make up the conscious state. All volatiles were once thought to act i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b064ab80b862a16307ebec9f17444d7
Publikováno v:
International Congress Series. 1283:119-125
Mutations in a gene that encodes an unusual ion channel significantly change the sensitivity of Drosophila to volatile anesthetics (VAs). As for any gene implicated by mutation, we would like to know whether the corresponding gene product is a mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0971d11a73a7f4f44571974c7e676e60
https://doi.org/10.1016/j.ics.2005.07.079
https://doi.org/10.1016/j.ics.2005.07.079
Publikováno v:
Current Biology. 12(24):2152-2158
A unique family of putative ion channels that are related to voltage-gated sodium and calcium channels has been identified in genomic and cDNA studies of metazoans [1, 2]. Aside from evidence for expression of family members in the nervous system [2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16efe45c470aa4273dd5911f13eb565c
Publikováno v:
Proceedings of the National Academy of Sciences. 99:14970-14975
Accidental or drug-induced interruption of the breakage and reunion cycle of eukaryotic topoisomerase I (Top1) yields complexes in which the active site tyrosine of the enzyme is covalently linked to the 3′ end of broken DNA. The enzyme tyrosyl-DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8315c8da27e8ccb39df087fe2510609
https://doi.org/10.1073/pnas.182557199
https://doi.org/10.1073/pnas.182557199
Publikováno v:
Genes to Cells. 6:677-687
Background The covalent linkage between DNA and the active site tyrosine of topoisomerase I can be stabilized by chemotherapeutic agents, adjacent DNA lesions, or mutational defects in the topoisomerase itself. Following collision with a replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6caae47d4e57693c0e78ad819e64c785
https://doi.org/10.1046/j.1365-2443.2001.00452.x
https://doi.org/10.1046/j.1365-2443.2001.00452.x