Zobrazeno 1 - 10
of 326
pro vyhledávání: '"Howard A. Fox"'
Autor:
Howard S. Fox, Meng Niu, Brenda M. Morsey, Benjamin G. Lamberty, Katy Emanuel, Palsamy Periyasamy, Shannon Callen, Arpan Acharya, Gregory Kubik, James Eudy, Chittibabu Guda, Shetty Ravi Dyavar, Courtney V. Fletcher, Siddappa N. Byrareddy, Shilpa Buch
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The twin pandemics of opioid abuse and HIV infection can have devastating effects on physiological systems, including on the brain. Our previous work found that morphine increased the viral reservoir in the brains of treated SIV-infected macaques. In
Externí odkaz:
https://doaj.org/article/bc2b1f24d5e446379cb54f6c41e6b1bb
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-11 (2021)
Abstract Background Microglia are resident innate immune cells in the brain, and activation of these myeloid cells results in secretion of a variety of pro-inflammatory molecules, leading to the development of neurodegenerative disorders. Lipopolysac
Externí odkaz:
https://doaj.org/article/f7e6eea6358146c2b56a13aa70a64ff8
Autor:
Zaeema Naveed, Howard S. Fox, Christopher S. Wichman, Morshed Alam, Pamela May, Christine M. Arcari, Jane Meza, Steven Totusek, Lorena Baccaglini
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract HIV-related neurocognitive impairment (NCI) may increase the risk of death. However, a survival disadvantage for patients with NCI has not been well studied in the post-combination antiretroviral therapy (cART) era. Specifically, limited res
Externí odkaz:
https://doaj.org/article/253c3d8a650448729dcff24a747c17af
Autor:
Dana Gabuzda, Beth D. Jamieson, Ronald G. Collman, Michael M. Lederman, Tricia H. Burdo, Steven G. Deeks, Dirk P. Dittmer, Howard S. Fox, Nicholas T. Funderburg, Savita G. Pahwa, Ivona Pandrea, Cara C. Wilson, Peter W. Hunt
Publikováno v:
Pathogens and Immunity, Vol 5, Iss 1, Pp 143-174 (2020)
People with HIV (PWH) experience accentuated biological aging, as defined by markers of inflammation, immune dysfunction, and the epigenetic clock. They also have an elevated risk of multiple age-associated comorbidities. To discuss current knowle
Externí odkaz:
https://doaj.org/article/67523edc367641d89c52c3931673c54e
Autor:
Andrew J. Trease, Joseph W. George, Nashanthea J. Roland, Eliezer Z. Lichter, Katy Emanuel, Steven Totusek, Howard S. Fox, Kelly L. Stauch
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Neurogenerative disorders, such as Alzheimer’s disease (AD), represent a growing public health challenge in aging societies. Tauopathies, a subset of neurodegenerative disorders that includes AD, are characterized by accumulation of fibrillar and h
Externí odkaz:
https://doaj.org/article/4ff4202ef63f4462963ca041402bc086
Autor:
Prasanta K. Dash, Fadhel A. Alomar, Jesse L. Cox, JoEllyn McMillan, Bryan T. Hackfort, Edward Makarov, Brenda Morsey, Howard S. Fox, Howard E. Gendelman, Santhi Gorantla, Keshore R. Bidasee
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Early-onset heart failure (HF) continues to be a major cause of morbidity and mortality in people living with human immunodeficiency virus type one (HIV-1) infection (PLWH), yet the molecular causes for this remain poorly understood. Herein NOD.Cg-Pr
Externí odkaz:
https://doaj.org/article/4f2a27b9809f46c2b078238674c554a2
Autor:
Subhash Chand, Austin Gowen, Mason Savine, Dalia Moore, Alexander Clark, Wendy Huynh, Niming Wu, Katherine Odegaard, Lucas Weyrich, Rick A. Bevins, Howard S. Fox, Gurudutt Pendyala, Sowmya V. Yelamanchili
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 14, Pp n/a-n/a (2021)
Abstract Extracellular vesicles (EVs), which express a repertoire of cargo molecules (cf. proteins, microRNA, lipids, etc.), have been garnering a prominent role in the modulation of several cellular processes. Here, using both non‐human primate an
Externí odkaz:
https://doaj.org/article/149df3527f264f1ea6f16d55dd9d1d37
Autor:
Omalla A. Olwenyi, Samuel D. Johnson, Kabita Pandey, Michellie Thurman, Arpan Acharya, Shilpa J. Buch, Howard S. Fox, Anthony T. Podany, Courtney V. Fletcher, Siddappa N. Byrareddy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Cytotoxic CD4+ T cells (CD4+ CTLs) limit HIV pathogenesis, as evidenced in elite controllers (a subset of individuals who suppress the virus without the need for therapy). CD4+ CTLs have also been shown to kill HIV-infected macrophages. However, litt
Externí odkaz:
https://doaj.org/article/7b1a650c52fb4f668c03c38b40167db0
Autor:
Rachel K. Spooner, Brittany K. Taylor, Cassandra M. Moshfegh, Iman M. Ahmad, Kelsey N. Dyball, Katy Emanuel, Sarah L. Schlichte, Mikki Schantell, Pamela E. May, Jennifer O'Neill, Maureen Kubat, Sara H. Bares, Susan Swindells, Howard S. Fox, Kelly L. Stauch, Tony W. Wilson, Adam J. Case, Matthew C. Zimmerman
Publikováno v:
EBioMedicine, Vol 70, Iss , Pp 103487- (2021)
Background: Despite effective combination antiretroviral therapy (cART), people living with HIV (PLWH) remain at risk for developing neurocognitive impairment primarily due to systemic inflammation that persists despite virologic suppression, albeit
Externí odkaz:
https://doaj.org/article/b50f42ee2a37464fa017a587f6243e26
Autor:
Olga Taraschenko, Howard S. Fox, Ember Eldridge, Wenyi Wang, Samuel W. Dowd, Fetweh Al-Saleem, Chandana Devi Kattala, Scott K. Dessain, Raymond Dingledine
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis manifests with precipitous cognitive decline, abnormal movements, and severe seizures that can be challenging to control with conventional anti-seizure medications. We previously demonstrated tha
Externí odkaz:
https://doaj.org/article/71d47a2269b244908681c9dd3b5ba929