Zobrazeno 1 - 10
of 636
pro vyhledávání: '"Howard A Young"'
Autor:
Natalia S Baez, Fabio Cerbán, Constanza Savid-Frontera, Deborah L Hodge, Jimena Tosello, Eva Acosta-Rodriguez, Laura Almada, Adriana Gruppi, Maria Estefania Viano, Howard A Young, Maria Cecilia Rodriguez-Galan
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007456 (2019)
Innate CD8+ T cells express a memory-like phenotype and demonstrate a strong cytotoxic capacity that is critical during the early phase of the host response to certain bacterial and viral infections. These cells arise in the thymus and depend on IL-4
Externí odkaz:
https://doaj.org/article/43f03edd76ac4cb3906db169ea8f71ab
Autor:
Pu Chen, Tayla J. Van Oers, Elena Arutyunova, Conrad Fischer, Chaoxiang Wang, Tess Lamer, Marco J. van Belkum, Howard S. Young, John C. Vederas, M. Joanne Lemieux
Publikováno v:
JACS Au, Vol 4, Iss 8, Pp 3217-3227 (2024)
Externí odkaz:
https://doaj.org/article/43087000c76649d4af843aa50a0189fd
Autor:
Shunsuke Sakai, Keith D Kauffman, Michelle A Sallin, Arlene H Sharpe, Howard A Young, Vitaly V Ganusov, Daniel L Barber
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005667 (2016)
IFN-γ-producing CD4 T cells are required for protection against Mycobacterium tuberculosis (Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated protection remains unclear. Furthermore, it is not known if increas
Externí odkaz:
https://doaj.org/article/7f77a02e79c44c3fbea7435cc5c4fc21
Autor:
Bibiana Barrios, Natalia S Baez, Della Reynolds, Pablo Iribarren, Hugo Cejas, Howard A Young, Maria Cecilia Rodriguez-Galan
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90116 (2014)
For more than a decade, the cytokine interleukin-12 (IL-12) has been utilized, either alone or in combination with other drugs, as a treatment for cancer. The numerous anti-tumor properties of IL-12 still generate interest in the clinical use of this
Externí odkaz:
https://doaj.org/article/4bafcbdf5e8d49178674e8297af0ed91
Autor:
Enitome E. Bafor, Rebecca A. Erwin-Cohen, Toni Martin, Clayton Baker, Adrienne E. Kimmel, Olivier Duverger, John M. Fenimore, Meredith Ramba, Thea Spindel, Megan M. Hess, Michael Sanford, Vanja Lazarevic, Bérénice A. Benayoun, Howard A. Young, Julio C. Valencia
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInterferon-gamma (IFN-γ) is pivotal in orchestrating immune responses during healthy pregnancy. However, its dysregulation, often due to autoimmunity, infections, or chronic inflammatory conditions, is implicated in adverse reproductive
Externí odkaz:
https://doaj.org/article/306b4bda4436411bb1b24ea0b8baf0db
Autor:
Elena Arutyunova, Alexandr Belovodskiy, Pu Chen, Muhammad Bashir Khan, Michael Joyce, Holly Saffran, Jimmy Lu, Zoe Turner, Bing Bai, Tess Lamer, Howard S. Young, John C. Vederas, D. Lorne Tyrrell, M. Joanne Lemieux, James A. Nieman
Publikováno v:
ACS Bio & Med Chem Au, Vol 3, Iss 6, Pp 528-541 (2023)
Externí odkaz:
https://doaj.org/article/b8e37dea5f004761a5ac48cc97ba66e2
Autor:
Adelle P McFarland, Ram Savan, Sagie Wagage, Augustina Addison, Karthika Ramakrishnan, Megan Karwan, Tri Duong, Howard A Young
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16967 (2011)
There have been conflicting reports of the role of Type I interferons (IFN) in inflammatory bowel disease (IBD). Clinical trials have shown potent efficacy of systemic interferon-beta (IFN-β) in inducing remission of ulcerative colitis. Likewise, IF
Externí odkaz:
https://doaj.org/article/4fc25fc810124f1ea73161c019dda885
Autor:
Enitome E. Bafor, Toni Martin, Jeffrey Carrell, Megan Karwan, Adrienne E. Kimmel, Uyi.G. Omogiade, Michael Sanford, Howard A. Young, Julio C. Valencia
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102710- (2023)
Summary: Here, we present a validated workflow to isolate sufficient viable single ovary cells from a single mouse without the need to pool from several mice. We provide steps essential for estrous staging, ovary harvesting and dissociation, ovary ce
Externí odkaz:
https://doaj.org/article/a204b491d83c43c8954512b2938a0cdf
Autor:
Sining Zhu, Almin I. Lalani, Juan Jin, Derek Sant’Angelo, Lori R. Covey, Kebin Liu, Howard A. Young, Suzanne Ostrand-Rosenberg, Ping Xie
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Myeloid-derived suppressor cells (MDSCs) are aberrantly expanded in cancer patients and under other pathological conditions. These cells orchestrate the immunosuppressive and inflammatory network to facilitate cancer metastasis and mediate patient re
Externí odkaz:
https://doaj.org/article/3745c414f1a94151b2992fbbc561abf7
Autor:
Caroline Andrews, Mairi H. McLean, Julie A. Hixon, Sergio M. Pontejo, Tregei Starr, Courtney Malo, Margaret Cam, Lisa Ridnour, Heather Hickman, Olivia Steele-Mortimer, David A. Wink, Howard A. Young, Daniel W. McVicar, Wenqing Li, Scott K. Durum
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mucosal delivery of IL-27 has been shown to have a therapeutic benefit in murine models of inflammatory bowel disease (IBD). The IL-27 effect was associated with phosphorylated STAT1 (pSTAT1), a product of IL27 receptor signaling, in bowel tissue. To
Externí odkaz:
https://doaj.org/article/63471c5b8e93457bbc461734fa452b98