Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Howard A Rockman"'
Autor:
Ferrin C Wheeler, Hao Tang, Odessa A Marks, Tracy N Hadnott, Pei-Lun Chu, Lan Mao, Howard A Rockman, Douglas A Marchuk
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000647 (2009)
The Calsequestrin (Csq) transgenic mouse model of cardiomyopathy exhibits wide variation in phenotypic progression dependent on genetic background. Seven heart failure modifier (Hrtfm) loci modify disease progression and outcome. Here we report Tnni3
Externí odkaz:
https://doaj.org/article/f19cefa24a264edd9414090580a3eab5
Autor:
Peter J Mohler, Jane A Healy, Hui Xue, Annibale A Puca, Crystal F Kline, R Rand Allingham, Evangelia G Kranias, Howard A Rockman, Vann Bennett
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e1051 (2007)
Here we report the unexpected finding that specific human ANK2 variants represent a new example of balanced human variants. The prevalence of certain ANK2 (encodes ankyrin-B) variants range from 2 percent of European individuals to 8 percent in indiv
Externí odkaz:
https://doaj.org/article/5b4cf91b56634b5aa5ef22c09bfdeaba
Autor:
Robert J. Lefkowitz, Howard A. Rockman, Paul J. Shim, Samuel Liu, Seungkirl Ahn, Biswaranjan Pani, Sudarshan Rajagopal, Sudha K. Shenoy, Michel Bouvier, Jeffrey L. Benovic, Stephen B. Liggett, Robert R. Ruffolo, Michael R. Bristow, Milton Packer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/1516c52dd4af4fd98dff325b5997c3e9
Publikováno v:
Cardiovascular Research. 119:1117-1129
G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface receptors, serve as fundamental modulators of cardiac health and disease owing to their key roles in the regulation of heart rate, contractile dynamics, and cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062233ac256af9081c5d04e49897215b
https://doi.org/10.1093/cvr/cvac171
https://doi.org/10.1093/cvr/cvac171
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C731-C748
G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range of physiological functions and in a large number of Food and Drug Administration (FDA)-approved drugs as therapeutic entities. With continued stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24acfd8e75a3a77d67cba860ea9f8ccf
https://doi.org/10.1152/ajpcell.00210.2022
https://doi.org/10.1152/ajpcell.00210.2022
Autor:
Jialu Wang, Kenji Hanada, Dean P. Staus, Michael A. Makara, Giri Raj Dahal, Qiang Chen, Andrea Ahles, Stefan Engelhardt, Howard A. Rockman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
β1 and β2 adrenergic receptors (ARs) are the predominant G protein-coupled receptor subtypes expressed in mammalian hearts. Here the authors describe a signaling mechanism where the biased agonist carvedilol converts β1AR from a classical Gαs-cou
Externí odkaz:
https://doaj.org/article/68ae6a57361e4d6dbe16011c3ee3cc38
Autor:
Seungkirl Ahn, Howard A. Rockman, Haoran Jiang, Ilhan Gokhan, Jialu Wang, Xinyu Xiong, Biswaranjan Pani, Robert J. Lefkowitz, Alem W. Kahsai
Publikováno v:
Mol Pharmacol
β(1) adrenergic receptors (β(1)ARs) are central regulators of cardiac function and a drug target for cardiac disease. As a member of the G protein–coupled receptor family, β(1)ARs activate cellular signaling by primarily coupling to Gs proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899cdde539ac9323e772614fd83c35b4
https://doi.org/10.1124/molpharm.121.000359
https://doi.org/10.1124/molpharm.121.000359
Autor:
Wenjing Xu, Tomasa Barrientos, Lan Mao, Howard A. Rockman, Anthony A. Sauve, Nancy C. Andrews
Publikováno v:
Cell Reports, Vol 13, Iss 3, Pp 533-545 (2015)
Both iron overload and iron deficiency have been associated with cardiomyopathy and heart failure, but cardiac iron utilization is incompletely understood. We hypothesized that the transferrin receptor (Tfr1) might play a role in cardiac iron uptake
Externí odkaz:
https://doaj.org/article/4493d1a2fd6b440a8871986c64d89b44
Publikováno v:
J Proteome Res
Angiotensin II type 1 receptors (AT1Rs) are one of the most widely studied G-protein-coupled receptors. To fully appreciate the diversity in cellular signaling profiles activated by AT1R transducer-biased ligands, we utilized peroxidase-catalyzed pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81f3cb2ce6efbe9d9f0151fd33e83cd
https://doi.org/10.1021/acs.jproteome.1c00080
https://doi.org/10.1021/acs.jproteome.1c00080
Relaxin-2 is a peptide hormone with important roles in human cardiovascular and reproductive biology. Its ability to activate cellular responses such as vasodilation, angiogenesis, and anti-inflammatory and anti-fibrotic effects have led to significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a775a626310ef29caca94a3581b86c4
https://doi.org/10.1101/2022.04.19.488796
https://doi.org/10.1101/2022.04.19.488796
