Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Howard, Mak"'
Autor:
Noor Momin, Joseph R. Palmeri, Emi A. Lutz, Noor Jailkhani, Howard Mak, Anthony Tabet, Magnolia M. Chinn, Byong H. Kang, Virginia Spanoudaki, Richard O. Hynes, K. Dane Wittrup
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Understanding the pharmacokinetics of locally-injected drugs could aid in the design of immunotherapies to maximize their therapeutic effect. Here, by evaluating different IL-2 fusion proteins, the authors show that molecular weight and matrix bindin
Externí odkaz:
https://doaj.org/article/29c0b5b17b1041eaaa47f6822400abb3
Autor:
Joy G. Ghosh, Andrew A. Nguyen, Chad E. Bigelow, Stephen Poor, Yubin Qiu, Nalini Rangaswamy, Richard Ornberg, Brittany Jackson, Howard Mak, Tucker Ezell, Vania Kenanova, Elisa de la Cruz, Ana Carrion, Bijan Etemad-Gilbertson, Roxana Garcia Caro, Kan Zhu, Vinney George, Jirong Bai, Radhika Sharma-Nahar, Siyuan Shen, Yiqin Wang, Kulandayan K. Subramanian, Elizabeth Fassbender, Michael Maker, Shawn Hanks, Joanna Vrouvlianis, Barrett Leehy, Debby Long, Melissa Prentiss, Viral Kansara, Bruce Jaffee, Thaddeus P. Dryja, Michael Roguska
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Retinal vascular disease treatments involve frequent pharmacological intraocular administrations. Here the authors present a method to increase the half-life of injected drugs by fusing these to a hyaluronan-binding peptide, which might lead to less
Externí odkaz:
https://doaj.org/article/f0adf43d440f4267b734d5d4506d7186
Autor:
Maria Kanelli, Neelkanth M. Bardhan, Morteza Sarmadi, Shahad Alsaiari, William T. Rothwell, Apurva Pardeshi, Dominique C. De Fiesta, Howard Mak, Virginia Spanoudaki, Nicole Henning, Jooli Han, Angela M. Belcher, Robert S. Langer, Ana Jaklenec
Publikováno v:
bioRxiv
Cancer therapy research is of high interest because of the persistence and mortality of the disease and the side effects of traditional therapeutic methods, while often multimodal treatments are necessary based on the patient’s needs. The developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13eb4e223daf50b902a9ce33fb0e9be
https://europepmc.org/articles/PMC10120681/
https://europepmc.org/articles/PMC10120681/
Autor:
Frank B. Gertler, Olivia J. Kelada, Emilia M Pulver, Sangeeta N. Bhatia, Henry Ko, Heather E. Fleming, Renee T. Zhao, Nazanin Rohani, Liangliang Hao, Howard Mak
Publikováno v:
Nature Materials. 20:1440-1448
Therapeutic outcomes in oncology may be aided by precision diagnostics that offer early detection, localization and the opportunity to monitor response to therapy. Here, we report a multimodal nanosensor engineered to target tumours through acidosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0514389bf5880fadb3562097c6f3e84b
https://doi.org/10.1038/s41563-021-01042-y
https://doi.org/10.1038/s41563-021-01042-y
Autor:
Jessica R. Ingram, Howard Mak, Mohammad Rashidian, Chenxi Tian, Richard O. Hynes, Steffen Rickelt, Hidde L. Ploegh, Noor Jailkhani, Zhigang Jiang
Publikováno v:
Proceedings of the National Academy of Sciences. 116:14181-14190
Extracellular matrix (ECM) deposition is a hallmark of many diseases, including cancer and fibroses. To exploit the ECM as an imaging and therapeutic target, we developed alpaca-derived libraries of "nanobodies" against disease-associated ECM protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3f62808860d146505e8d209ab37468
https://doi.org/10.1073/pnas.1817442116
https://doi.org/10.1073/pnas.1817442116
Autor:
Liangliang, Hao, Nazanin, Rohani, Renee T, Zhao, Emilia M, Pulver, Howard, Mak, Olivia J, Kelada, Henry, Ko, Heather E, Fleming, Frank B, Gertler, Sangeeta N, Bhatia
Publikováno v:
Nature materials. 20(10)
Therapeutic outcomes in oncology may be aided by precision diagnostics that offer early detection, localization and the opportunity to monitor response to therapy. Here, we report a multimodal nanosensor engineered to target tumours through acidosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::729ef51a2c500ff74e4ac420cebb11e2
https://pubmed.ncbi.nlm.nih.gov/34561628
https://pubmed.ncbi.nlm.nih.gov/34561628