Zobrazeno 1 - 10
of 342
pro vyhledávání: '"Howard, Gurney"'
Autor:
Irfan Cicin, Elizabeth R. Plimack, Howard Gurney, Raya Leibowitz, Boris Y. Alekseev, Francis X. Parnis, Avivit Peer, Andrea Necchi, Joaquim Bellmunt, Hiroyuki Nishiyama, Jason Clark, Mihaela Munteanu, Ritesh Kataria, Calvin Jia, Thomas Powles, Cora N. Sternberg
Publikováno v:
BMC Cancer, Vol 23, Iss S1, Pp 1-11 (2024)
Abstract Background Indoleamine 2,3-dioxygenase 1 (IDO1) levels correlate with poor outcomes in urothelial carcinoma (UC). IDO1 and programmed death-ligand 1 (PD-L1) are often co-expressed. Epacadostat is a potent and highly selective inhibitor of ID
Externí odkaz:
https://doaj.org/article/263d9199baf8485699909ce6591e41d9
Autor:
Andrea Necchi, Michiel S. Van der Heijden, Dmytro Trukhin, Avivit Peer, Howard Gurney, Boris Y. Alekseev, Francis X. Parnis, Raya Leibowitz, Maria De Santis, Petros Grivas, Jason Clark, Mihaela Munteanu, Ritesh Kataria, Calvin Jia, Arjun V. Balar, Ronald de Wit
Publikováno v:
BMC Cancer, Vol 23, Iss S1, Pp 1-11 (2024)
Abstract Background Indoleamine 2,3- dioxygenase 1 (IDO1) is an immunosuppressive enzyme that has been correlated with shorter disease-specific survival in patients with urothelial carcinoma (UC). IDO1 may counteract the antitumor effects of immune c
Externí odkaz:
https://doaj.org/article/37a2f0fcea5140a684940d22b18e5a1a
Publikováno v:
Case Reports in Oncology, Vol 17, Iss 1, Pp 717-724 (2024)
Introduction: Prostate cancer most commonly metastasizes to the bone and lymph nodes. Gastrointestinal metastasis has been noted in the literature but appears to be an exceedingly uncommon phenomenon. Large intestinal involvement in particular has be
Externí odkaz:
https://doaj.org/article/827b6dd7f37a452c880558b496c8aaa9
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 1370-1377 (2023)
Introduction: Spinal epidural metastases (SEM) are an uncommon phenomenon and traditionally occur as a preterminal event in heavily pre-treated patients. The introduction of novel anti-androgen therapies, such as enzalutamide and abiraterone acetate,
Externí odkaz:
https://doaj.org/article/b035a9be47804fe48e9e235e3932f961
Autor:
Benjamin Daniels, Maria Aslam, Marina T. van Leeuwen, Martin Brown, Lee Hunt, Howard Gurney, Monica Tang, Sallie-Anne Pearson, Claire M. Vajdic
Publikováno v:
The Lancet Regional Health. Western Pacific, Vol 39, Iss , Pp 100872- (2023)
Summary: Background: Cardiovascular disease (CVD) and cancer are leading causes of death and people with cancer are at higher risk of developing CVD than the general population. Many cancer medicines have cardiotoxic effects but the size of the popul
Externí odkaz:
https://doaj.org/article/e33bd71aea8e4da8bb5871e89e0c8096
Autor:
Lauren J Brown, Ines Pires da Silva, Tania Moujaber, Bo Gao, Rina Hui, Howard Gurney, Matteo Carlino, Adnan Nagrial
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 6788-6801 (2023)
Abstract Aims There is robust trial evidence for improved overall survival (OS) with immunotherapy in advanced solid organ malignancies. The real‐world long‐term survival data and the predictive variables are not yet known. Our aim was to evaluat
Externí odkaz:
https://doaj.org/article/6bb5dd3aed074dbb932c0084ce042e5f
Publikováno v:
Journal of Urological Surgery, Vol 10, Iss 1, Pp 77-81 (2023)
Primary urethral carcinomas account for less than one percent of all genitourinary cancers. Primary clear cell adenocarcinoma of the urethra (CCAU) is an extremely rare and aggressive tumor which predominantly presents in adult women but has rarely b
Externí odkaz:
https://doaj.org/article/92b8538b34734b91a9ff13d89c2633dd
Autor:
Vita Birzniece, Mark McLean, Navneeta Reddy, Haleh Shahidipour, Amy Hayden, Howard Gurney, Glenn Stone, Rikke Hjortebjerg, Jan Frystyk
Publikováno v:
Endocrine Connections, Vol 11, Iss 4, Pp 1-11 (2022)
Objective: Androgen deprivation therapy (ADT), a principal therapy in patients with prostate cancer, is associated with the development of obesity, insulin resistance, and hyperinsulinemia. Recent evidence indicates that metformin may slow cancer pro
Externí odkaz:
https://doaj.org/article/0a47a53c69904edfbcbbd85b5cb5d8c0
Autor:
Dhanusha Sabanathan, Douglas Campbell, Vicki Velonas, Sandra Wissmueller, Hubert Mazure, Marko Trifunovic, Pirooz Poursoltan, Kevin Ho-Shon, Tiffany Mackay, Maria Lund, Yanling Lu, Paul Roach, Dale Bailey, Bradley Walsh, David Gillatt, Howard Gurney
Publikováno v:
Asia Oceania Journal of Nuclear Medicine and Biology, Vol 9, Iss 2, Pp 86-100 (2021)
Objective(s): Miltuximab® is a chimeric antibody targeting Glypican-1 (GPC-1), a cell surface antigen which is overexpressed in solid cancers. Miltuximab® has shown promising safety and efficacy in radioimmunotherapy models of prostate cancer. This
Externí odkaz:
https://doaj.org/article/e54133442db347f2aa83af2e911eee7d
Autor:
Clara Inkyung Lee, Siew Kee Low, Ricardo Maldonado, Peter Fox, Bavanthi Balakrishnar, Sally Coulter, Peter de Bruijn, Stijn L.W. Koolen, Bo Gao, Jodi Lynch, Nicholas Zdenkowski, Rina Hui, Christopher Liddle, Ron H.J. Mathijssen, Nicholas Wilcken, Mark Wong, Howard Gurney
Publikováno v:
Breast, Vol 54, Iss , Pp 229-234 (2020)
Introduction: CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (E). CYP2D6 polymorphisms are common and can affect CYP2D6 protein activity and E level. Some retrospective studies indicate that E 35;
Externí odkaz:
https://doaj.org/article/ee0a0636acad496f8fd6fecf0cdfe594