Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Hovhannes J. Gukasyan"'
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Background: The interstitial testicular Leydig cells are responsible for the production of testosterone, which functionally deteriorate with normal aging. Decreased expression of mitochondrial steroidogenic interactome proteins and diminished mitocho
Externí odkaz:
https://doaj.org/article/409c580d6a544c919e9fae47a2ae3e03
Autor:
Daniel B. Martinez–Arguelles, Jennifer W. Nedow, Hovhannes J. Gukasyan, Vassilios Papadopoulos
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
Cholesterol is the precursor of all steroid hormones, and the entry of cholesterol into the mitochondria is the rate-limiting step of steroidogenesis. Voltage-dependent anion channel (VDAC1) is an outer mitochondrial protein part of a multiprotein co
Externí odkaz:
https://doaj.org/article/c3ee8794f5c74d61b1aabddb90f426f9
Autor:
Mikhail Martchenko Shilman, Leandra O. Gonzalez, Wai Gee, Thomas Henderson, Jeffrey D. Palumbo, Hovhannes J. Gukasyan
Publikováno v:
SOJ Microbiology & Infectious Diseases. 9:1-9
Flies naturally contain microbes in their intestines after eating microbe-rich food like decaying fruits. When ingesting microbes, insects are also exposed to their toxins. The sensitivity of insects to ingested microbial toxins and their mechanism o
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics
The study objective was to investigate molecular thermodynamic properties of approved ophthalmic drugs and derive a framework outlining physicochemical design space for product development. Unlike the methodology used to obtain molecular descriptors
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:220-229
PF06821497 has been identified as an orally available small-molecule enhancer of zeste homolog 2 inhibitor. The objectives of the present study were to characterize pharmacokinetic-pharmacodynamic-disease relationships of PF06821497 in xenograft mous
Autor:
Kephart Susan Elizabeth, Manfred Kraus, Hovhannes J. Gukasyan, Sutton Scott Channing, Joseph H Lee, Zehnder Luke Raymond, Shinji Yamazaki, Pei-Pei Kung, Buwen Huang, Connie Fan
Publikováno v:
Journal of medicinal chemistry. 64(3)
A pyridone-derived phosphate prodrug of an enhancer of zeste homolog 2 (EZH2) inhibitor was designed and synthesized to improve the inhibitor's aqueous solubility. This prodrug (compound 5) was profiled in pharmacokinetic experiments to assess its ab
Autor:
Hovhannes J. Gukasyan, Richard Graham
Publikováno v:
Ophthalmic Product Development ISBN: 9783030763664
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cc02b8364aa4714c6b485a20ee76600
https://doi.org/10.1007/978-3-030-76367-1_11
https://doi.org/10.1007/978-3-030-76367-1_11
Autor:
Michael R. Collins, Robert Steven Kania, Connie Fan, Sutton Scott Channing, Dominique Verhelle, Kephart Susan Elizabeth, Martin James Wythes, Shuiwang Wang, Karen A. Maegley, Lisa Nguyen, Daniel Tyler Richter, A.E. Stewart, Pei-Pei Kung, Buwen Huang, Shikhar Sharma, Shinji Yamazaki, Ya-Li Deng, Rita Grantner, Patrick Bingham, Robert Arnold Kumpf, Penney Khamphavong, Jinjiang Zhu, Dac M. Dinh, Manfred Kraus, Wei Liu, Sean Uryu, Jillian E. Spangler, Wenyue Hu, Hui Wang, Robert A. Rollins, Cody Krivacic, Zehnder Luke Raymond, Neal W. Sach, Alexei Brooun, John Sherrill, Shijian Ren, Martin A. Edwards, Huichun Zhu, Ketan S. Gajiwala, Shuibo Xin, Hovhannes J. Gukasyan
Publikováno v:
Journal of Medicinal Chemistry. 61:650-665
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Publikováno v:
Pharmaceutical research. 36(5)
Publikováno v:
Drug discovery today. 24(8)
The estimation of ocular pharmacokinetics (PK) in various eye tissues is limited because of sampling challenges. Computational modeling and simulation (M&S) tools underpinning the elucidation of drug access routes and prediction of ocular exposure ar