Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Hovav, Nechushtan"'
Autor:
Michal Lotem, Limor Rubin, Aviv Talmon, Yaarit Ribak, David Lavie, Hovav Nechushtan, Nadia Caplan, Oded Shamriz, Irit Adini, Yuval Tal
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)
Given the broad implementation of immune checkpoint inhibitors (ICI) for cancer therapy, we encounter a variety of immune-related adverse events (irAE) including immune-related blood eosinophilia. Eosinophilia demonstrated a potential positive predic
Externí odkaz:
https://doaj.org/article/f6e42c9984c04b73a8c8df5cf2496e0f
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The main known function of Nudix hydrolase 2 (Nudt2) is to hydrolyze the secondary messenger diadenosine 5’, 5’’’-p1, p4-tetraphosphate (Ap4A). In this study we examined the role of Nudt2 in breast carcinoma through its expression in human in
Externí odkaz:
https://doaj.org/article/830bf0a3f4714809ac310c98574ffbc0
Autor:
Avital Granit Mizrahi, Ahinoam Gugenheim, Haneen Hamad, Roa’a Hamed, Nino Tetro, Ofra Maimon, Salome Khutsurauli, Hovav Nechushtan, Benjamin Nisman, Deborah Duran, Widad Samman, Liron Birimberg-Schwartz, Myriam Grunewald, Sara Eyal, Tamar Peretz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
We recently demonstrated that the histone deacetylase inhibitor valproic acid (VPA) reprograms the cisplatin-induced metabolome of triple-negative breast cancer (TNBC) cells, including a shift in hexose levels. Accordingly, here, we tested the hypoth
Externí odkaz:
https://doaj.org/article/5c2f7c8cf790418bbeab010b21580f0d
Autor:
Shay Golan, Vered Bar, Seth J. Salpeter, Guy Neev, German Creiderman, Daniel Kedar, Sara Aharon, Lubov Turovsky, Adi Zundelevich, Hamutal Shahar, Hagit Shapira, Giuseppe Mallel, Erez Stossel, Nancy Gavert, Ravid Straussman, Zohar Dotan, Raanan Berger, Chani Stossel, Talia Golan, Sharon Halperin, Dan Leibovici, Shani Breuer, Yakir Rottenberg, Liat Applebaum, Ayala Hubert, Hovav Nechushtan, Tamar Peretz, Aviad Zick, Boris Chertin, Dmitry Koulikov, Amir Sonnenblick, Eli Rosenbaum
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionEx vivo organ cultures (EVOC) were recently optimized to sustain cancer tissue for 5 days with its complete microenvironment. We examined the ability of an EVOC platform to predict patient response to cancer therapy.MethodsA multicenter,
Externí odkaz:
https://doaj.org/article/9e606d0806d6437093649828fdd409d0
Publikováno v:
Pathology and Oncology Research, Vol 29 (2023)
Background: Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC), however are frequently associated with thyroid immune-related adverse events (IRAEs). We investigated the association be
Externí odkaz:
https://doaj.org/article/e9177c5c795f417cb68feb1803ec7c2b
Autor:
Or Sehayek, Waleed Kian, Amir Onn, Ronen Stoff, Hadas Gantz Sorotsky, Melanie Zemel, Jair Bar, Yulia Dudnik, Hovav Nechushtan, Yakir Rottenberg, Lior Soussan-Gutman, Addie Dvir, Laila C. Roisman, Nir Peled
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
PurposeMolecular profiling is crucial in naïve non-small cell lung cancer (NSCLC). While tissue-based analysis is challenged by turnaround time and scarcity of tissue, there is increasing demand for liquid biopsy. We aimed to analyze the use of upfr
Externí odkaz:
https://doaj.org/article/85362ec588224779aae89838b8d19a1d
Autor:
Johnathan Arnon, MD, Anna Elia, MD, Yuval Nevo, PhD, Alexander Lossos, MD, Hovav Nechushtan, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 9, Pp 100217- (2021)
SCLC is frequently associated with paraneoplastic syndromes, including dermatomyositis. Patients with malignancy-associated dermatomyositis express a specific autoantibody pattern usually positive for anti–transcription intermediary factor 1-γ (TI
Externí odkaz:
https://doaj.org/article/f32e8f962c194b0d85a35752b2719ea4
Autor:
Shin La Shu, Lakshmi Bhargavi Paruchuru, Neil Quanwei Tay, Yen Leong Chua, Adeline Shen Yun Foo, Chris Maolin Yang, Ka Hang Liong, Esther Geok Liang Koh, Angeline Lee, Hovav Nechushtan, Ehud Razin, David Michael Kemeny
Publikováno v:
iScience, Vol 16, Iss , Pp 524-534 (2019)
Summary: The significance of intracellular Ap4A levels over immune activity of dendritic cells (DCs) has been studied in Nudt2fl/fl/CD11c-cre mice. The transgenic mice have been generated by crossing floxed NUDT2 gene mice with DC marker CD11c recomb
Externí odkaz:
https://doaj.org/article/2ad9b8ba0a034f238d00b701abe20030
Autor:
Julia Rotow, Jyoti D. Patel, Matthew P. Hanley, Helena Yu, Mark Awad, Jonathan W. Goldman, Hovav Nechushtan, Matthias Scheffler, Chih-Hsi S. Kuo, Senthil Rajappa, Guilherme Harada, Sarah Clifford, Alison Santucci, Laura Silva, Rebecca Tupper, Geoffrey R. Oxnard, Jennifer Kherani, Alexander Drilon
Publikováno v:
Clinical Cancer Research. :OF1-OF9
Purpose: Acquired RET fusions have been reported at resistance to treatment with EGFR inhibitors in EGFR-mutant non–small cell lung cancer (NSCLC); however, a multicenter cohort of patients with EGFR-mutant lung cancers treated with osimertinib and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93367ade8865e82d62769701bfe0a6a1
https://doi.org/10.1158/1078-0432.ccr-22-2189
https://doi.org/10.1158/1078-0432.ccr-22-2189
Autor:
Gad Rennert, Maya Gottfried, Hedy S Rennert, Flavio Lejbkowicz, Meira Frank, Ilana Cohen, Shiri Kelt, Abed Agbarya, Elizabeta Dudnik, Julia Dudnik, Rivka Katznelson, Moshe Mishali, Natalie Maimon Rabinovich, Hovav Nechushtan, Amir Onn, Shoshana Keren Rosenberg, Mariana Wollner, Alona Zer, Jair Bar, Naomi Gronich
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100934- (2021)
Purpose: A substantial fraction of all non-small cell lung cancers(NSCLC) carry a mutation in the EGFR gene for which an effective treatment with anti-tyrosine kinases(TKIs) is available. We studied the long term survival of these patients following
Externí odkaz:
https://doaj.org/article/26a31ca9e38842c584e0074d2e96db7d