Intratumoral expression analysis reveals that OX40 and TIM-3 are prominently expressed and have variable associations with clinical outcomes in high grade serous ovarian cancer.

Autor: James NE; Department of Obstetrics and Gynecology, Program in Women's Oncology, Women and Infants Hospital, Providence, RI 02903, USA.; Warren Alpert Medical School, Brown University, Providence, RI 02903, USA., Valenzuela AD; Department of Obstetrics and Gynecology, Program in Women's Oncology, Women and Infants Hospital, Providence, RI 02903, USA., Emerson JB; Department of Obstetrics and Gynecology, Program in Women's Oncology, Women and Infants Hospital, Providence, RI 02903, USA., Woodman M; Department of Obstetrics and Gynecology, Program in Women's Oncology, Women and Infants Hospital, Providence, RI 02903, USA., Miller K; Department of Obstetrics and Gynecology, Program in Women's Oncology, Women and Infants Hospital, Providence, RI 02903, USA., Hovanesian V; Rhode Island Hospital, Core Research Laboratories, Women and Infants Hospital, Providence, RI 02903, USA., Ou J; Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.; Department of Pathology, Women and Infants Hospital, Providence, RI 02903, USA., Ribeiro JR; Department of Obstetrics and Gynecology, Program in Women's Oncology, Women and Infants Hospital, Providence, RI 02903, USA.; Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.

Publikováno v: Oncology letters [Oncol Lett] 2022 Jun; Vol. 23 (6), pp. 188. Date of Electronic Publication: 2022 Apr 26.

HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression.

Autor: Rowswell-Turner RB; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY rachael_turner@urmc.rochester.edu.; Division of Hematology and Oncology, Department of Internal Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY., Singh RK; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY., Urh A; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hofstra University, East Garden City, NY., Yano N; Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI., Kim KK; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY., Khazan N; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY., Pandita R; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY., Sivagnanalingam U; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY., Hovanesian V; Core Research Laboratories, Rhode Island Hospital, Providence, RI., James NE; Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI., Ribeiro JR; Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI., Kadambi S; Division of Hematology and Oncology, Department of Internal Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY., Linehan DC; Division of Surgical Oncology, Department of Surgery, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY., Moore RG; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 May 15; Vol. 206 (10), pp. 2478-2488. Date of Electronic Publication: 2021 Apr 26.

The biomarker HE4 (WFDC2) promotes a pro-angiogenic and immunosuppressive tumor microenvironment via regulation of STAT3 target genes.

Autor: James NE; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA., Emerson JB; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA.; Warren-Alpert Medical School of Brown University, Providence, RI, USA., Borgstadt AD; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA.; Warren-Alpert Medical School of Brown University, Providence, RI, USA., Beffa L; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA.; Warren-Alpert Medical School of Brown University, Providence, RI, USA., Oliver MT; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA.; Warren-Alpert Medical School of Brown University, Providence, RI, USA., Hovanesian V; Rhode Island Hospital, Digital Imaging and Analysis Core Facility, Providence, RI, USA., Urh A; Northwell Health Physician Partners Gynecologic Oncology, Brightwaters, NY, USA., Singh RK; University of Rochester Medical Center, Rochester, NY, USA., Rowswell-Turner R; University of Rochester Medical Center, Rochester, NY, USA., DiSilvestro PA; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA.; Warren-Alpert Medical School of Brown University, Providence, RI, USA., Ou J; Warren-Alpert Medical School of Brown University, Providence, RI, USA.; Women and Infants Hospital, Department of Pathology, Providence, RI, USA., Moore RG; University of Rochester Medical Center, Rochester, NY, USA., Ribeiro JR; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA. Jrribeiro@wihri.org.; Warren-Alpert Medical School of Brown University, Providence, RI, USA. Jrribeiro@wihri.org.

Publikováno v: Scientific reports [Sci Rep] 2020 May 22; Vol. 10 (1), pp. 8558. Date of Electronic Publication: 2020 May 22.

The Impact of High-Dose Fish Oil Supplementation on Mfsd2a, Aqp4, and Amyloid-β Expression in Retinal Blood Vessels of 5xFAD Alzheimer's Mouse Model.

Autor: Jovanovic Macura, Irena¹ (AUTHOR) irena.macura@ibiss.bg.ac.rs, Milanovic, Desanka¹ (AUTHOR) desan@ibiss.bg.ac.rs, Tesic, Vesna¹ (AUTHOR) vesna.tesic@lsuhs.edu, Major, Tamara² (AUTHOR) majtamara@gmail.com, Perovic, Milka¹ (AUTHOR) milkap@ibiss.bg.ac.rs, Adzic, Miroslav³ (AUTHOR) miraz@vin.bg.ac.rs, Ivkovic, Sanja³ (AUTHOR) sivkovic@vin.bg.ac.rs

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9400. 17p.

Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus.

Autor: Chen X; Department of Pediatrics, The Alpert Medical School of Brown University, Women & Infants Hospital of Rhode Island, Providence, RI, United States., Hovanesian V; Core Research Laboratories, The Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, United States., Naqvi S; Department of Pediatrics, The Alpert Medical School of Brown University, Women & Infants Hospital of Rhode Island, Providence, RI, United States., Lim YP; ProThera Biologics, Inc, Providence, RI, United States., Tucker R; Department of Pediatrics, The Alpert Medical School of Brown University, Women & Infants Hospital of Rhode Island, Providence, RI, United States., Donahue JE; Department of Pathology and Neurosurgery, The Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, United States., Stopa EG; Department of Pathology and Neurosurgery, The Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, United States., Stonestreet BS; Department of Pediatrics, The Alpert Medical School of Brown University, Women & Infants Hospital of Rhode Island, Providence, RI, United States. Electronic address: bstonestreet@wihri.org.

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2018 Jan; Vol. 67, pp. 24-35. Date of Electronic Publication: 2017 Aug 02.