Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes

Autor: de Haan, H.G., van Hylckama Vlieg, A., Lotta, L.A., Gorski, M.M., Bucciarelli, P., Martinelli, I., Baglin, T.P., Peyvandi, F., Rosendaal, F.R. ^*, Amouyel, P., de Andrade, M., Basu, S., Berr, C., Brody, J.A., Chasman, D. I, Dartigues, J.‐F., Folsom, A.R., Germain, M., Heit, J., Houwing‐Duitermaat, J., Kabrhel, C., Kraft, P., Le Gal, G., Lindström, S., Monajemi, R., Morange, P.‐E., Psaty, B.M., Reitsma, P.H., Ridker, P.M., Rose, L.M., Saut, N., Slagboom, E., Smadja, D., Smith, N.L., Suchon, P., Tang, W., Taylor, K.D., Trégouët, D.‐A., Tzourio, C., de Visser, M.C.H., Weng, L.‐C., Wiggins, K.L.

Publikováno v: In Journal of Thrombosis and Haemostasis December 2018 16(12):2432-2441

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.

Autor: Germain M; Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, 75013 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, 75013 Paris, France; Institute for Cardiometabolism and Nutrition (ICAN), 75013 Paris, France., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA., de Haan H; Department of Thrombosis and Hemostasis, Department of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands., Tang W; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA., Lindström S; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Weng LC; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA., de Andrade M; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN 55905, USA., de Visser MC; Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Wiggins KL; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA., Suchon P; Laboratory of Haematology, La Timone Hospital, 13385 Marseille, France; INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, 13385 Marseille, France; Nutrition Obesity and Risk of Thrombosis, Aix-Marseille University, UMR_S 1062, 13385 Marseille, France., Saut N; Laboratory of Haematology, La Timone Hospital, 13385 Marseille, France; INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, 13385 Marseille, France; Nutrition Obesity and Risk of Thrombosis, Aix-Marseille University, UMR_S 1062, 13385 Marseille, France., Smadja DM; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; AP-HP, Hopital Européen Georges Pompidou, Service d'Hématologie Biologique, 75015 Paris, France; Faculté de Pharmacie, INSERM, UMR_S 1140, 75006 Paris, France., Le Gal G; Université de Brest, EA3878 and CIC1412, 29238 Brest, France; Ottawa Hospital Research Institute at the University of Ottawa, Ottawa, ON K1Y 4E9, Canada., van Hylckama Vlieg A; Department of Thrombosis and Hemostasis, Department of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands., Di Narzo A; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA., Hao K; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, LE1 7RH Leicester, UK; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Leicester LE3 9QP, UK., Rocanin-Arjo A; Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, 75013 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, 75013 Paris, France; Institute for Cardiometabolism and Nutrition (ICAN), 75013 Paris, France., Folkersen L; Department of PharmacoGenetics, Novo Nordisk Park 9.1.21, 2400 Copenhagen, Denmark., Monajemi R; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Brody JA; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA 98195-5852, USA., Slagboom E; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Aïssi D; Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, 75013 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, 75013 Paris, France; Institute for Cardiometabolism and Nutrition (ICAN), 75013 Paris, France., Gagnon F; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada., Deleuze JF; Commissariat à l'Energie Atomique/Direction des Sciences du Vivant/Institut de Génomique, Centre National de Génotypage, 91057 Evry, France., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia., Tzourio C; Inserm Research Center U897, University of Bordeaux, 33000 Bordeaux, France., Dartigues JF; Inserm Research Center U897, University of Bordeaux, 33000 Bordeaux, France., Berr C; Inserm Research Unit U1061, University of Montpellier I, 34000 Montpellier, France., Taylor KD; Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrence, CA 90502, USA., Civelek M; Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Eriksson P; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA 98195-5852, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA., Houwing-Duitermaat J; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Goodall AH; Department of Cardiovascular Sciences, University of Leicester, LE1 7RH Leicester, UK; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Leicester LE3 9QP, UK., Cambien F; Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, 75013 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, 75013 Paris, France; Institute for Cardiometabolism and Nutrition (ICAN), 75013 Paris, France., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Amouyel P; Institut Pasteur de Lille, Université de Lille Nord de France, INSERM UMR_S 744, 59000 Lille, France; Centre Hospitalier Régional Universitaire de Lille, 59000 Lille, France., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, LE1 7RH Leicester, UK; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Leicester LE3 9QP, UK., Basu S; Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA., Rosendaal FR; Department of Thrombosis and Hemostasis, Department of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands., Kabrhel C; Department of Emergency Medicine, Massachusetts General Hospital, Channing Network Medicine, Harvard Medical School, Boston, MA 2114, USA., Folsom AR; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA., Heit J; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA., Reitsma PH; Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Trégouët DA; Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, 75013 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, 75013 Paris, France; Institute for Cardiometabolism and Nutrition (ICAN), 75013 Paris, France., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA; Seattle Epidemiologic Research and Information Center, VA Office of Research and Development, Seattle, WA 98108, USA. Electronic address: nlsmith@u.washington.edu., Morange PE; Laboratory of Haematology, La Timone Hospital, 13385 Marseille, France; INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, 13385 Marseille, France; Nutrition Obesity and Risk of Thrombosis, Aix-Marseille University, UMR_S 1062, 13385 Marseille, France. Electronic address: pierre.morange@ap-hm.fr.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2015 Apr 02; Vol. 96 (4), pp. 532-42. Date of Electronic Publication: 2015 Mar 12.

Thrombophilia screening revisited: an issue of personalized medicine.

Autor: Colucci, Giuseppe, Tsakiris, Dimitrios A.

Publikováno v: Journal of Thrombosis & Thrombolysis; May2020, Vol. 49 Issue 4, p618-629, 12p

Effects of Genetically Determined Iron Status on Risk of Venous Thromboembolism and Carotid Atherosclerotic Disease: A Mendelian Randomization Study.

Autor: Gill, Dipender, Brewer, Christopher F., Monori, Grace, Trégouët, David-Alexandre, Franceschini, Nora, Giambartolomei, Claudia, Tzoulaki, Ioanna, Dehghan, Abbas, INVENT Consortium

Publikováno v: Journal of the American Heart Association; 8/6/2019, Vol. 8 Issue 15, p1-9, 45p

Metabolites Associated With the Risk of Incident Venous Thromboembolism: A Metabolomic Analysis.

Autor: Xia Jiang, Zeleznik, Oana A., Lindström, Sara, Lasky-Su, Jessica, Hagan, Kaitlin, Clish, Clary B., Eliassen, A. Heather, Kraft, Peter, Kabrhel, Christopher, Jiang, Xia

Publikováno v: Journal of the American Heart Association; 11/20/2018, Vol. 7 Issue 22, p1-18, 26p