Výsledky vyhledávání - "Houston Gilbert"

338 Emerging insights on the association of tumor molecular phenotype with clinical benefit in metastatic colorectal cancer (mCRC) subjects treated with AB928 + modified FOLFOX-6 (mFOLFOX-6)

Autor: Kristen Zhang, Michael Cecchini, Kimberline Gerrick, Juan C. Jaen, Olivia Gardner, Amy E. Anderson, Lisa Seitz, Akshata Udyavar, Matthew Walters, William Grossman, Daniel DiRenzo, Sean Cho, Stephen P. Young, Houston Gilbert, Cheng Quah

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Background The release of ATP from dying cancer cells in response to platinum-based chemotherapy increases extracellular adenosine, which binds to and activates A2aR and A2bR receptors to generate an immunosuppressive microenvironment. This is mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3570f3efaeed0c2b4ba1e0c482f59f01
https://doaj.org/article/4bb49219c48a4df9a64820fd1d9aed2c

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Can Graphics Tell Lies? A Tutorial on How To Visualize Your Data

Autor: Sofia Mosesova, Christopher R. Cabanski, Houston Gilbert

Publikováno v: Clinical and Translational Science. 11:371-377

Visualizations are a powerful tool for telling a story about a data set or analysis. If done correctly, visualizations not only display data but also help the audience digest key information. However, if done haphazardly, visualization has the potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba0030c387f898cb8e97dffc28a34103
https://doi.org/10.1111/cts.12554

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Current Status of Companion and Complementary Diagnostics: Strategic Considerations for Development and Launch

Autor: Vinita Gupta, S Chen, H Scheerens, H Stevens, A Malong, S Simnett, K Bassett, Houston Gilbert, L Essioux, J. O. Harris, P Risser, J Jordan, JA Williams, R Kalamegham, C Mesick, Z Boyd, J Engel

Publikováno v: Clinical and Translational Science. 10:84-92

US Food and Drug Administration (FDA)-approved diagnostic assays play an increasingly common role in managing patients to prolong lifespan while also enhancing quality of life. Diagnostic assays can be essential for the safe and effective use of ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a11ea6a03c117bec8ba332c3bd91f4ae
https://doi.org/10.1111/cts.12455

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A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study)

Autor: Carol Aghajanian, Yulei Wang, Jill M. Spoerke, Shan Lu, Ling-Yuh Huw, Ursula A. Matulonis, Rui Zhu, Vicky Makker, Houston Gilbert, Hema Parmar, Ling Ma, Fernando O. Recio, Mark R. Lackner, Joseph A. Ware, Jennifer O. Lauchle, Hartmut Koeppen

Publikováno v: Cancer. 122:3519-3528

BACKGROUND The current single-arm, open-label trial was designed to evaluate the activity of apitolisib (GDC-0980), a dual phosphoinositide 3-kinase/mammalian target of rapamycin (PI3K/mTOR) inhibitor, in patients with advanced endometrial cancer (EC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d33de98628b96ee8ea339b75a6df36d
https://doi.org/10.1002/cncr.30286

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Abstract LB-387: Efficacy and safety of AB928 plus modified FOLFOX-6 (mFOLFOX-6) in participants with metastatic colorectal cancer (mCRC): Initial results at the recommended dose for expansion (ARC-3)

Autor: Daniel DiRenzo, Houston Gilbert, Melissa Paoloni, Fadi Braiteh, Matt J. Walters, Manuel Modiano, Michael Cecchini, Olivia Gardner, Lisa Seitz, Fang-Fang Yin, Rachel Woloski, Ki Y. Chung

Publikováno v: Cancer Research. 80:LB-387

Background: The release of ATP from dying cancer cells in response to platinum-based chemotherapy increases extracellular immunosuppressive adenosine (A), which binds to and activates the A2a and A2b receptors on immune cells resulting in an ineffect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f883bbb86e130e5cbaf6496d16b3f789
https://doi.org/10.1158/1538-7445.am2020-lb-387

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ARC-4 study: Efficacy and safety of AB928 plus carboplatin, pemetrexed and a PD-1 antibody in participants with metastatic non-small cell lung cancer (mNSCLC)

Autor: Paul Conkling, Olivia Gardner, Melissa Lynne Johnson, Houston Gilbert, Alexander I. Spira, Kartik Krishnan, Arvind Chaudhry, Fang-Fang Yin, Melissa Paoloni, Michael Scharville

Publikováno v: Journal of Clinical Oncology. 38:e21659-e21659

e21659 Background: Adenosine, derived from ATP released by dying cancer cells in response to chemotherapy, binds to and activates the A2a and A2b receptors on immune cells, resulting in an ineffective anti-tumor immune response. Adenosine receptor bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbc9bec3c4c5b294092700f03dcc52cd
https://doi.org/10.1200/jco.2020.38.15_suppl.e21659

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A phase Ib/II, open-label, platform study evaluating the efficacy and safety of AB928-based treatment combinations in participants with metastatic castrate-resistant prostate cancer

Autor: Kartik Krishnan, Aimee Rieger, Houston Gilbert, David R. Wise, Olivia Gardner, Melissa Paoloni

Publikováno v: Journal of Clinical Oncology. 38:TPS272-TPS272

TPS272 Background: The tumor microenvironment contains high levels of immunosuppressive adenosine, which binds to and activates the A2a and A2b receptors (R) on immune cells, resulting in an ineffective anti-tumor immune response. Extracellular adeno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f6eb37c7d6f7f976a647576714a5136
https://doi.org/10.1200/jco.2020.38.6_suppl.tps272

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