Investigating novel molecular regulators of the auditory ribbon synapses of mammalian inner hair cells

Autor: Houston, Oliver

The auditory ribbon synapse is highly specialised to regulate the release of glutamate from IHCs and generate action potentials in auditory afferent fibres in response to small and graded changes in the receptor potential of IHCs. This is essential f

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684547

Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing

Autor: Buniello, Annalisa, Ingham, Neil J., Lewis, Morag A., Huma, Andreea C., Martinez-Vega, Raquel, Varela-Nieto, Isabel, Vizcay-Barrena, Gema, Fleck, Roland A., Houston, Oliver, Bardhan, Tanaya, Johnson, Stuart L., White, Jacqueline K., Yuan, Huijun, Marcotti, Walter, Steel, Karen P.

Publikováno v: Buniello, A, Ingham, N J, Lewis, M A, Huma, A C, Martinez-Vega, R, Varela-Nieto, I, Vizcay-Barrena, G, Fleck, R A, Houston, O, Bardhan, T, Johnson, S L, White, J K, Yuan, H, Marcotti, W & Steel, K P 2016, ' Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing ', EMBO Molecular Medicine, vol. 8, no. 3, pp. 191-207 . https://doi.org/10.15252/emmm.201505523

WBP2 encodes the WW domain-binding protein 2 that acts as a transcriptional coactivator for estrogen receptor α (ESR1) and progesterone receptor (PGR). We reported that the loss of Wbp2 expression leads to progressive high-frequency hearing loss in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::d0200f5a0fe89e2146bc272d1f07dca9
https://kclpure.kcl.ac.uk/en/publications/111b4a1e-5499-42a4-9b60-cced801d48c0

Chapter 6 - Functional Development of Hair Cells in the Mammalian Inner Ear

Autor: Corns, Laura F., Bardhan, Tanaya, Houston, Oliver, Olt, Jennifer, Holley, Matthew C., Masetto, Sergio, Johnson, Stuart L., Marcotti, Walter

Publikováno v: In Development of Auditory and Vestibular Systems Edition: Fourth Edition. 2014:155-188