Výsledky vyhledávání - "Houssein Al-Attrache"

Cigarette smoke interacts with amiodarone toxicity in Saccharomyces cerevisiae

Autor: Houssein Al‐Attrache, Iman Halloum, Lara Hammoud, Katia El Ghoz, Ziad Abdel‐Razzak

Publikováno v: Journal of Applied Toxicology. 43:764-768

Amiodarone (AMD) is an antiarrhythmic drug prescribed to treat ventricular tachycardia and fibrillation. However, it causes an unpredictable toxicity (idiosyncratic), which may depend on co-exposure to pollutants. AMD toxicity involves calcium homeos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb287b680644d2f62b7f314a7f32150
https://doi.org/10.1002/jat.4413

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Dose-dependent interaction of two heavy metals with amiodarone toxicity in

Autor: Iman, Halloum, Houssein, Al-Attrache, Katia, El-Ghoz, Lara, Hammoud, Ziad, Abdel-Razzak

Publikováno v: Toxicology and industrial health. 38(5)

Amiodarone (AMD) is an antiarrhythmic drug that induces idiosyncratic toxicity. Environmental pollutants, including heavy metals, could interact with its toxicity by affecting pharmacokinetics and pharmacodynamics. Other levels of interaction could e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6eec6486193f41bde4e6ea940bd5efa2
https://pubmed.ncbi.nlm.nih.gov/35513769

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N-acetylcysteine potentiates diclofenac toxicity in Saccharomyces cerevisiae: stronger potentiation in ABC transporter mutant strains

Autor: Houssein Al-Attrache, Ziad Abdel-Razzak, Monzer Hamzé, Hala Chamieh, Samir Taha, Isabelle Morel

Publikováno v: Drug and Chemical Toxicology
Drug and Chemical Toxicology, Taylor & Francis, 2018, 41 (1), pp.89-94. ⟨10.1080/01480545.2017.1320404⟩
Drug and Chemical Toxicology, 2018, 41 (1), pp.89-94. ⟨10.1080/01480545.2017.1320404⟩

International audience; Diclofenac (DCF) adverse reactions involve diverse mechanisms in different models. We recently demonstrated that DCF-induced toxicity in HepaRG decreases as they express DCF-metabolizing enzymes. DCF metabolism promotes toxici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2c22f2509d50d30a0c255dd0e2a993
https://doi.org/10.1080/01480545.2017.1320404

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Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-alpha

Autor: Isabelle Morel, Ziad Abdel-Razzak, Thomas Gicquel, Matthew Burbank, Audrey Burban, Houssein Al-Attrache, André Guillouzo, Christiane Guguen-Guillouzo, Ahmad Sharanek

Publikováno v: Toxicology Letters
Toxicology Letters, Elsevier, 2016, 258, pp.71--86. ⟨10.1016/j.toxlet.2016.06.008⟩
Toxicology Letters, 2016, 258, pp.71--86. ⟨10.1016/j.toxlet.2016.06.008⟩

International audience; The role of reactive metabolites and inflammatory stress has been largely evoked in idiosyncratic hepatotoxicity of diclofenac (DCF); however mechanisms remain poorly understood. We aimed to evaluate the influence of liver cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6cbbfd2cd2eaf215eeea411f45c311
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01372855

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Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells

Autor: Houssein Al-Attrache, Ziad Abdel-Razzak, Isabelle Morel, André Guillouzo, Camille C Savary, Sylvie Lepage, Ahmad Sharanek, Pamela Bachour-El Azzi, Gilles Labbe, Christiane Guguen-Guillouzo, Sébastien Anthérieu

Publikováno v: Drug Metabolism and Disposition
Drug Metabolism and Disposition, American Society for Pharmacology and Experimental Therapeutics (ASPET), 2014, 42 (9), pp.1556-66. ⟨10.1124/dmd.114.058123⟩
Drug Metabolism and Disposition, 2014, 42 (9), pp.1556-66. ⟨10.1124/dmd.114.058123⟩

International audience; Several factors are thought to be implicated in the occurrence of idiosyncratic adverse drug reactions. The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14651d0235a8c0cfb1c01f67cbec7c2
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134764

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Different Dose-Dependent Mechanisms are Involved in Early Cyclosporine A-Induced Cholestatic Effects in HepaRG Cells

Autor: Ahmad Sharanek, Houssein Al-Attrache, Lydie Humbert, Camille C Savary, Pamela Bachour-El Azzi, André Guillouzo, Christiane Guguen-Guillouzo, Dominique Rainteau

Publikováno v: Review of Economic Dynamics
Review of Economic Dynamics, Elsevier, 2014, 141 (1), pp.244-253. ⟨10.1093/toxsci/kfu122⟩
Review of Economic Dynamics, 2014, 141 (1), pp.244-253. ⟨10.1093/toxsci/kfu122⟩

International audience; : Mechanisms involved in drug-induced cholestasis in humans remain poorly understood. Although cyclosporine A (CsA) and tacrolimus (FK506) share similar immunosuppressive properties, only CsA is known to cause dose-dependent c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ed0a1c2715dfdf828ad331a5cdeca7
https://hal.archives-ouvertes.fr/hal-01016342

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