PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation

Autor: Maria Stahl Madsen, Marjoleine F. Broekema, Martin Rønn Madsen, Arjen Koppen, Anouska Borgman, Cathrin Gräwe, Elisabeth G. K. Thomsen, Denise Westland, Mariette E. G. Kranendonk, Marian Groot Koerkamp, Nicole Hamers, Alexandre M. J. J. Bonvin, José M. Ramos Pittol, Kedar Nath Natarajan, Sander Kersten, Frank C. P. Holstege, Houshang Monajemi, Saskia W. C. van Mil, Michiel Vermeulen, Birthe B. Kragelund, David Cassiman, Susanne Mandrup, Eric Kalkhoven

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Mutations in PPARγ lead to lipodystrophy, but the mechanisms by which the mutations affect the activity in chromatin is unknown. Here, Madsen, Broekema et al. showed that mutations affecting two intermolecular interactions compromise chromatin remod

Externí odkaz: https://doaj.org/article/bb99d7ed4031494bb213b8c0686b2ffe

Smartphone Application-Assisted Home Blood Pressure Monitoring Compared With Office and Ambulatory Blood Pressure Monitoring in Patients With Hypertension: the AMUSE-BP Study

Autor: Eline H. Groenland, Jean-Paul A.C. Vendeville, Remy H.H. Bemelmans, Houshang Monajemi, Michiel L. Bots, Frank L.J. Visseren, Wilko Spiering

Publikováno v: Hypertension. 79:2373-2382

Background: The development of automated, smartphone application (app)-assisted home blood pressure monitoring (HBPM) allows for standardized measurement of blood pressure (BP) at home. The aim of this study was to evaluate the (diagnostic) agreement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6766e5e60a957580fc1ace6af90292cb
https://doi.org/10.1161/hypertensionaha.122.19685

Assessment of Imaging Modalities Against Liver Biopsy in Nonalcoholic Fatty Liver Disease: The Amsterdam NAFLD‐NASH Cohort

Autor: A. H. Zwinderman, Anne Marieke van Dijk, Julia J. Witjes, Otto M. van Delden, Max Nieuwdorp, Aart J. Nederveen, Sandjai Ramsoekh, Diona Zwirs, Houshang Monajemi, Ulrich Beuers, Joanne Verheij, Jurgen H. Runge, Marije ten Wolde, Marian A. Troelstra, Ralph Sinkus, Oliver J. Gurney-Champion, Anne L. Mak, Daniela Stols-Gonçalves, Adriaan G. Holleboom

Publikováno v: Journal of magnetic resonance imaging, 54(6), 1937-1949. John Wiley and Sons Inc.
Journal of Magnetic Resonance Imaging
Journal of Magnetic Resonance Imaging, Wiley-Blackwell, In press, ⟨10.1002/jmri.27703⟩
Ann Transl Med

Background: Noninvasive diagnostic methods are urgently required in disease stratification and monitoring in nonalcoholic fatty liver disease (NAFLD). Multiparametric magnetic resonance imaging (MRI) is a promising technique to assess hepatic steatos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ed40ced0a5d3cd3e9fa6e9ca4ee946
https://doi.org/10.1002/jmri.27703

Arterial Wall Inflammation and Increased Hematopoietic Activity in Patients With Primary Aldosteronism

Autor: Leo A. B. Joosten, Jaap Deinum, Alexander Hoischen, Charlotte D C C van der Heijden, Mihai G. Netea, Marlies P. Noz, Charlotte Kaffa, Esther M.M. Smeets, Simone Kersten, Erik H.J.G. Aarntzen, Houshang Monajemi, Niels P. Riksen

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 105, 5
Journal of Clinical Endocrinology and Metabolism, 105
The Journal of Clinical Endocrinology and Metabolism

Context Primary aldosteronism (PA) confers an increased risk of cardiovascular disease (CVD), independent of blood pressure. Animal models have shown that aldosterone accelerates atherosclerosis through proinflammatory changes in innate immune cells;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63c89ad2b6c093d5938603f99e3db88
https://doi.org/10.1210/clinem/dgz306

An Oral Mixed Fat Load Is Followed by a Modest Anti-inflammatory Adipocytokine Response in Overweight Patients with Metabolic Syndrome

Autor: Houshang Monajemi, Gideon R. Hajer, Mariëtte E.G. Kranendonk, Jan Westerink, Eric Kalkhoven, Henk S. Schipper, Frank L.J. Visseren

Publikováno v: Lipids. 49:247-254

We investigated the postprandial changes in plasma levels of adipocytokines in overweight patients with metabolic syndrome after an oral fat load. After an oral fat load and during a prolonged fast, blood was drawn at 0, 2, 3, 4 and 8 h for measureme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726bd3ea7d369e6d2dccdafc4f6458f5
https://doi.org/10.1007/s11745-014-3877-8