PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease.

Autor: Perrin F; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA. fperrin@mgh.harvard.edu., Anderson LC; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA., Mitchell SPC; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA., Sinha P; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA., Turchyna Y; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA., Maesako M; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA., Houser MCQ; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA., Zhang C; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA., Wagner SL; Department of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA.; VA San Diego Healthcare System, La Jolla, CA, 92161, USA., Tanzi RE; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA., Berezovska O; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA. oberezovska@mgh.harvard.edu.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Oct 21; Vol. 12 (1), pp. 166. Date of Electronic Publication: 2024 Oct 21.

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling.

Autor: Zoltowska KM; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium., Das U; Department of Neurosciences, University of California San Diego, La Jolla, United States., Lismont S; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium., Enzlein T; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany., Maesako M; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Charlestown, United States., Houser MCQ; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Charlestown, United States., Franco ML; Molecular Basis of Neurodegeneration Unit, Instituto de Biomedicina de Valencia, Valencia, Spain., Özcan B; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium., Gomes Moreira D; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium., Karachentsev D; Department of Neurosciences, University of California San Diego, La Jolla, United States., Becker A; Department of Neurosciences, University of California San Diego, La Jolla, United States., Hopf C; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany.; Medical Faculty, Heidelberg University, Heidelberg, Germany.; Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Vilar M; Molecular Basis of Neurodegeneration Unit, Instituto de Biomedicina de Valencia, Valencia, Spain., Berezovska O; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Charlestown, United States., Mobley W; Department of Neurosciences, University of California San Diego, La Jolla, United States., Chávez-Gutiérrez L; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.

Publikováno v: ELife [Elife] 2024 Jul 19; Vol. 12. Date of Electronic Publication: 2024 Jul 19.

Sigma Receptor Ligands Are Potent Antiprion Compounds that Act Independently of Sigma Receptor Binding.

Autor: Mercer RCC; Department of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States., Le NTT; Department of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States., Fraser DG; Department of Chemistry, Boston University, Boston, Massachusetts 02215, United States., Houser MCQ; Department of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States., Beeler AB; Department of Chemistry, Boston University, Boston, Massachusetts 02215, United States., Harris DA; Department of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Jun 05; Vol. 15 (11), pp. 2265-2282. Date of Electronic Publication: 2024 May 14.

PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease.

Autor: Perrin F; Massachusetts General Hospital., Anderson LC; Massachusetts General Hospital., Mitchell SPC; Massachusetts General Hospital., Sinha P; Massachusetts General Hospital., Turchyna Y; Massachusetts General Hospital., Maesako M; Massachusetts General Hospital., Houser MCQ; Massachusetts General Hospital., Zhang C; Massachusetts General Hospital., Wagner SL; VA San Diego Healthcare System., Tanzi RE; Massachusetts General Hospital., Berezovska O; Massachusetts General Hospital.

Publikováno v: Research square [Res Sq] 2023 Nov 07. Date of Electronic Publication: 2023 Nov 07.

In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons.

Autor: McKendell AK; Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, 114, 16th street, Charlestown, MA 02129, USA., Houser MCQ; Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, 114, 16th street, Charlestown, MA 02129, USA., Mitchell SPC; Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, 114, 16th street, Charlestown, MA 02129, USA., Wolfe MS; Department of Medicinal Chemistry, University of Kansas, 1567 Irving Hill Rd, Lawrence, Kansas City, KS 66045, USA., Berezovska O; Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, 114, 16th street, Charlestown, MA 02129, USA., Maesako M; Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, 114, 16th street, Charlestown, MA 02129, USA.

Publikováno v: Biosensors [Biosensors (Basel)] 2022 Aug 20; Vol. 12 (8). Date of Electronic Publication: 2022 Aug 20.