Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

Autor: Lotta, Luca A., Mokrosiński, Jacek, Mendes de Oliveira, Edson, Li, Chen, Sharp, Stephen J., Luan, Jian’an, Brouwers, Bas, Ayinampudi, Vikram, Bowker, Nicholas, Kerrison, Nicola, Kaimakis, Vasileios, Hoult, Diana, Stewart, Isobel D., Wheeler, Eleanor, Day, Felix R., Perry, John R.B., Langenberg, Claudia, Wareham, Nicholas J., Farooqi, I. Sadaf

Publikováno v: In Cell 18 April 2019 177(3):597-607

Prediction of acute myeloid leukaemia risk in healthy individuals

Autor: Abelson, Sagi, Collord, Grace, Ng, Stanley WK, Weissbrod, Omer, Mendelson Cohen, Netta, Niemeyer, Elisabeth, Barda, Noam, Zuzarte, Philip C, Heisler, Lawrence, Sundaravadanam, Yogi, Luben, Robert, Hayat, Shabina, Wang, Ting Ting, Zhao, Zhen, Cirlan, Iulia, Pugh, Trevor J, Soave, David, Ng, Karen, Latimer, Calli, Hardy, Claire, Raine, Keiran, Jones, David, Hoult, Diana, Britten, Abigail, McPherson, John D, Johansson, Mattias, Mbabaali, Faridah, Eagles, Jenna, Miller, Jessica K, Pasternack, Danielle, Timms, Lee, Krzyzanowski, Paul, Awadalla, Philip, Costa, Rui, Segal, Eran, Bratman, Scott V, Beer, Philip, Behjati, Sam, Martincorena, Inigo, Wang, Jean CY, Bowles, Kristian M, Quirós, J Ramón, Karakatsani, Anna, La Vecchia, Carlo, Trichopoulou, Antonia, Salamanca-Fernández, Elena, Huerta, José M, Barricarte, Aurelio, Travis, Ruth C, Tumino, Rosario, Masala, Giovanna, Boeing, Heiner, Panico, Salvatore, Kaaks, Rudolf, Krämer, Alwin, Sieri, Sabina, Riboli, Elio, Vineis, Paolo, Foll, Matthieu, McKay, James, Polidoro, Silvia, Sala, Núria, Khaw, Kay-Tee, Vermeulen, Roel, Campbell, Peter J, Papaemmanuil, Elli, Minden, Mark D, Tanay, Amos, Balicer, Ran D, Wareham, Nicholas J, Gerstung, Moritz, Dick, John E, Brennan, Paul, Vassiliou, George S, Shlush, Liran I

The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa15f39b824b8663666a7a7eae06d0ce

Prediction of acute myeloid leukaemia risk in healthy individuals

Autor: Aurelio Barricarte, Claire Hardy, Kristian M. Bowles, Abigail Britten, Mattias Johansson, Sabina Sieri, Kay-Tee Khaw, Sagi Abelson, Philip A. Beer, Stanley W.K. Ng, Matthieu Foll, Lee Timms, Diana Hoult, Salvatore Panico, Shabina Hayat, Elena Salamanca-Fernández, Paul M. Krzyzanowski, Rosario Tumino, Noam Barda, José María Huerta, Lawrence E. Heisler, Jean C.Y. Wang, Inigo Martincorena, Mark D. Minden, Robert Luben, John E. Dick, Trevor J. Pugh, Sam Behjati, Anna Karakatsani, Philip Awadalla, Carlo La Vecchia, Zhen Zhao, Ruth C. Travis, Iulia Cirlan, Omer Weissbrod, Giovanna Masala, Heiner Boeing, Rui Costa, Elio Riboli, Nicholas J. Wareham, Calli Latimer, Philip C. Zuzarte, David T. Jones, Ting Ting Wang, J. Ramón Quirós, Grace Collord, Peter J. Campbell, Roel Vermeulen, Yogi Sundaravadanam, Elli Papaemmanuil, Antonia Trichopoulou, Ran D. Balicer, James McKay, Alwin Krämer, Jessica Miller, Keiran Raine, Jenna Eagles, Paolo Vineis, Netta Mendelson Cohen, Silvia Polidoro, Scott V. Bratman, Amos Tanay, Moritz Gerstung, George S. Vassiliou, Paul Brennan, Eran Segal, Karen Ng, Rudolf Kaaks, Núria Sala, David Soave, Faridah Mbabaali, Danielle Pasternack, Liran I. Shlush, John Douglas Mcpherson, Elisabeth Niemeyer

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Nature
Nature, vol 559, iss 7714
Nature, 559(7714), 400. Nature Research

The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be01f4f1010e52c78f7ac72708f01bf
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