Genetic analyses identify widespread sex-differential participation bias

Autor: Pirastu N., Cordioli M., Nandakumar P., Mignogna G., Abdellaoui A., Hollis B., Kanai M., Rajagopal V. M., Parolo P. D. B., Baya N., Carey C. E., Karjalainen J., Als T. D., Van der Zee M. D., Day F. R., Ong K. K., Agee M., Aslibekyan S., Bell R. K., Bryc K., Clark S. K., Elson S. L., Fletez-Brant K., Fontanillas P., Furlotte N. A., Gandhi P. M., Heilbron K., Hicks B., Huber K. E., Jewett E. M., Jiang Y., Kleinman A., Lin K. -H., Litterman N. K., Luff M. K., McIntyre M. H., McManus K. F., Mountain J. L., Mozaffari S. V., Noblin E. S., Northover C. A. M., O'Connell J., Petrakovitz A. A., Pitts S. J., Poznik G. D., Sathirapongsasuti J. F., Shelton J. F., Shringarpure S., Tian C., Tung J. Y., Tunney R. J., Vacic V., Wang X., Zare A., Mortensen P. B., Mors O., Werge T., Nordentoft M., Hougaard D. M., Bybjerg-Grauholm J., Baekvad-Hansen M., Morisaki T., de Geus E., Bellocco R., Okada Y., Borglum A. D., Joshi P., Auton A., Hinds D., Neale B. M., Walters R. K., Nivard M. G., Perry J. R. B., Ganna A.

Publikováno v: Nature Genetics, 53(5), 663-671. Nature Publishing Group
Nature genetics, 53(5), 663-671. Nature Publishing Group
Pirastu, N, Cordioli, M, Nandakumar, P, Mignogna, G, Abdellaoui, A, Hollis, B, Kanai, M, Rajagopal, V M, Parolo, P D B, Baya, N, Carey, C E, Karjalainen, J, Als, T D, Zee, M D V D, Day, F R, Ong, K K, Morisaki, T, Geus, E D, Bellocco, R, Okada, Y, Børglum, A D, Joshi, P, Auton, A, Hinds, D, Neale, B M, Walters, R K, Nivard, M G, Perry, J R B & Ganna, A 2021, ' Genetic analyses identify widespread sex-differential participation bias ', Nature Genetics, vol. 53, 53, pp. 663 . https://doi.org/10.1038/s41588-021-00846-7
Pirastu, N, Cordioli, M, Nandakumar, P, Mignogna, G, Abdellaoui, A, Hollis, B, Kanai, M, Rajagopal, V M, Parolo, P D B, Baya, N, Carey, C E, Karjalainen, J, Als, T D, Van der Zee, M D, Day, F R, Ong, K K, Morisaki, T, de Geus, E, Bellocco, R, Okada, Y, Børglum, A D, Joshi, P, Auton, A, Hinds, D, Neale, B M, Walters, R K, Nivard, M G, Perry, J R B, Ganna, A, FinnGen Study, 23andMe Research Team & iPSYCH Consortium 2021, ' Genetic analyses identify widespread sex-differential participation bias ', Nature Genetics, vol. 53, no. 5, pp. 663-671 . https://doi.org/10.1038/s41588-021-00846-7
Nat Genet
Pirastu, N, Cordioli, M, Nandakumar, P, Mignogna, G, Abdellaoui, A, Hollis, B, Kanai, M, Rajagopal, V M, Parolo, P D B, Baya, N, Carey, C E, Karjalainen, J, Als, T D, Van Der Zee, M D, Day, F R, Ong, K K, Morisaki, T, De Geus, E, Bellocco, R, Okada, Y, Børglum, A D, Joshi, P, Auton, A, Hinds, D, Neale, B M, Walters, R K, Nivard, M G, Perry, J R B & Ganna, A 2021, ' Genetic analyses identify widespread sex-differential participation bias ', Nature Genetics, vol. 53, no. 5, pp. 663-671 . https://doi.org/10.1038/s41588-021-00846-7

Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic basis of participation bias is challenging since it requires the genotypes of unseen individ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a71745af8272663af6b52258d6ed8794
https://doi.org/10.1038/s41588-021-00846-7

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Autor: Steinthorsdottir, V. (Valgerdur), McGinnis, R. (Ralph), Williams, N. O. (Nicholas O.), Stefansdottir, L. (Lilja), Thorleifsson, G. (Gudmar), Shooter, S. (Scott), Fadista, J. (Joao), Sigurdsson, J. K. (Jon K.), Auro, K. M. (Kirsi M.), Berezina, G. (Galina), Borges, M.-C. (Maria-Carolina), Bumpstead, S. (Suzannah), Bybjerg-Grauholm, J. (Jonas), Colgiu, I. (Irina), Dolby, V. A. (Vivien A.), Dudbridge, F. (Frank), Engel, S. M. (Stephanie M.), Franklin, C. S. (Christopher S.), Frigge, M. L. (Michael L.), Frisbaek, Y. (Yr), Geirsson, R. T. (Reynir T.), Geller, F. (Frank), Gretarsdottir, S. (Solveig), Gudbjartsson, D. F. (Daniel F.), Harmon, Q. (Quaker), Hougaard, D. M. (David Michael), Hegay, T. (Tatyana), Helgadottir, A. (Anna), Hjartardottir, S. (Sigrun), Jaeaeskelaeinen, T. (Tiina), Johannsdottir, H. (Hrefna), Jonsdottir, I. (Ingileif), Juliusdottir, T. (Thorhildur), Kalsheker, N. (Noor), Kasimov, A. (Abdumadjit), Kemp, J. P. (John P.), Kivinen, K. (Katja), Klungsoyr, K. (Kari), Lee, W. K. (Wai K.), Melbye, M. (Mads), Miedzybrodska, Z. (Zosia), Moffett, A. (Ashley), Najmutdinova, D. (Dilbar), Nishanova, F. (Firuza), Olafsdottir, T. (Thorunn), Perola, M. (Markus), Pipkin, F. B. (Fiona Broughton), Poston, L. (Lucilla), Prescott, G. (Gordon), Saevarsdottir, S. (Saedis), Salimbayeva, D. (Damilya), Scaife, P. J. (Paula Juliet), Skotte, L. (Line), Staines-Urias, E. (Eleonora), Stefansson, O. A. (Olafur A.), Sorensen, K. M. (Karina Meden), Thomsen, L. C. (Liv Cecilie Vestrheim), Tragante, V. (Vinicius), Trogstad, L. (Lill), Simpson, N. A. (Nigel A. B.), Laivuori, H. (Hannele), Morgan, L. (Linda), Aripova, T. (Tamara), Casas, J. P. (Juan P.), Dominiczak, A. F. (Anna F.), Walker, J. J. (James J.), Thorsteinsdottir, U. (Unnur), Iversen, A.-C. (Ann-Charlotte), Feenstra, B. (Bjarke), Lawlor, D. A. (Deborah A.), Boyd, H. A. (Heather Allison), Magnus, P. (Per), Zakhidova, N. (Nodira), Svyatova, G. (Gulnara), Stefansson, K. (Kari), Heinonen, S. (Seppo), Kajantie, E. (Eero), Kere, J. (Juha), Pouta, A. (Anneli), Macphail, S. (Sheila), Kilby, M. (Mark), Habiba, M. (Marwan), Williamson, C. (Catherine), O'Shaughnessy, K. (Kevin), O'Brien, S. (Shaughn), Cameron, A. (Alan), Redman, C. W. (Christopher W. G.), Farrall, M. (Martin), Caulfield, M. (Mark)

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the mater

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::713ac193a060d057a00aaf0cad530608
http://urn.fi/urn:nbn:fi-fe2021082343899

MR spectroscopy of hepatic fat and adiponectin and leptin levels during testosterone therapy in type 2 diabetes: a randomized, double-blinded, placebo-controlled trial:A randomized, double-blinded, placebo-controlled trial

Autor: Magnussen, L V, Andersen, P E, Diaz, Alejandro Rafael, Ostojic, J, Højlund, K., Hougaard, D. M., Christensen, Anders Nymark, Nielsen, T. L., Andersen, M

Publikováno v: Magnussen, L V, Andersen, P E, Diaz, A R, Ostojic, J, Højlund, K, Hougaard, D M, Christensen, A N, Nielsen, T L & Andersen, M 2017, ' MR spectroscopy of hepatic fat and adiponectin and leptin levels during testosterone therapy in type 2 diabetes: a randomized, double-blinded, placebo-controlled trial : A randomized, double-blinded, placebo-controlled trial ', European Journal of Endocrinology, vol. 177, no. 2, pp. 157-168 . https://doi.org/10.1530/EJE-17-0071

Men with type 2 diabetes mellitus (T2D) often have lowered testosterone levels and an increased risk of cardiovascular disease (CVD). Ectopic fat increases the risk of CVD, whereas subcutaneous gluteofemoral fat protects against CVD and has a benefic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1202::3bae53f3a19cd4e2d6e0b3a2bebd27d1
https://orbit.dtu.dk/en/publications/6170d8f6-dcb6-497d-95fd-395e1411597d

Genome-wide association study identifies five new schizophrenia loci

Autor: Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., Lin, D., Duan, J., Ophoff, R. A., Andreassen, O. A., Scolnick, E., Cichon, S., Clair, D. S., Corvin, A., Gurling, H., Werge, T., Rujescu, D., D. H. R., Pato, C. N., Malhotra, A. K., Purcell, S., Dudbridge, F., Neale, B. M., Rossin, L., Visscher, P. M., Posthuma, D., Ruderfer, D. M., Fanous, A., Stefansson, H., Steinberg, S., Mowry, B. J., Golimbet, V., Hert, M. D., Jönsson, E. G., Bitter, I., O. P. H., Collier, D. A., Tosato, Sarah, Agartz, I., Albus, M., Alexander, M., Amdur, R. L., Amin, F., Bass, N., Bergen, S. E., Black, D. W., Børglum, A. D., Brown, M. A., Bruggeman, R., Buccola, N. G., Byerley, W. F., Cahn, W., Cantor, R. M., Carr, V. J., Catts, S. V., Choudhury, K., Cloninger, C. R., Cormican, P., Craddock, N., Danoy, P. A., Datta, S., Haan, L. d., Demontis, D., Dikeos, D., Djurovic, S., Donnelly, P., Donohoe, G., Duong, L., Dwyer, S., Fink Jensen, A., Freedman, R., Freimer, N. B., Friedl, M., Georgieva, L., Giegling, I., Gill, M., Glenthøj, B., Godard, S., Hamshere, M., Hansen, M., Hansen, T., Hartmann, A. M., Henskens, F. A., Hougaard, D. M., Hultman, C. M., Ingason, A., Jablensky, A. V., Jakobsen, K. D., Jay, M., Jürgens, G., Kahn, R. S., Keller, M. C., Kenis, G., Kenny, E., Kim, Y., Kirov, G. K., Konnerth, H., Konte, B., Krabbendam, L., Krasucki, R., Lasseter, V. K., Laurent, C., Lawrence, J., Lencz, T., Lerer, F. B., Liang, K., Lichtenstein, P., Lieberman, J. A., Linszen, D. H., Lönnqvist, J., Loughland, C. M., Maclean, A. W., Maher, B. S., Maier, W., Mallet, J., Malloy, P., Mattheisen, M., Mattingsdal, M., Mcghee, K. A., Mcgrath, J. J., Mcintosh, A., Mclean, D. E., Mcquillin, A., Melle, I., Michie, P. T., Milanova, V., Morris, D. W., Mors, O., Mortensen, P. B., Moskvina, V., Muglia, P., Myin Germeys, I., Nertney, D. A., Nestadt, G., Nielsen, J., Nikolov, I., Nordentoft, M., Norton, N., Nöthen, M. M., O'Dushlaine, C. T., Olincy, A., Olsen, L., O'Neill, F. A., Orntoft, T. F., Owen, M. J., Pantelis, C., Papadimitriou, G., Pato, M. T., Peltonen, L., Petursson, H., Pickard, B., Pimm, J., Pulver, A. E., Puri, V., Quested, D., Quinn, E. M., Rasmussen, H. B., Réthelyi, J. M., Ribble, R., Rietschel, M., Riley, B. P., Ruggeri, Mirella, Schall, U., Schulze, T. G., Schwab, S. G., Scott, R. J., Shi, J., Sigurdsson, E., Silverman, J. M., C. C. A., Stefansson, K., Strange, A., Strengman, E., Stroup, T. S., Suvisaari, J., Terenius, L., Thirumalai, S., Thygesen, J. H., Timm, S., Toncheva, D., Den, E. v., J. v., Os, Winkel, R. v., Veldink, J., Walsh, D., Wang, A. G., Wiersma, D., Wildenauer, D. B., Williams, H. J., Williams, N. M., Wormley, B., Zammit, S., Sullivan, P. F., O'Donovan, M. C., Daly, M. J., Gejman, P. V., Genome Wide, S. P.

Publikováno v: Nature genetics, 43(10), 969-976. Nature Publishing Group
Nature Genetics; Vol 43
Ripke, S, Sanders, A R, Kendler, K S, Levinson, D F, Sklar, P, Holmans, P A, Lin, D Y, Duan, J, Ophoff, R A, Andreassen, O A, Scolnick, E, Cichon, S, St Clair, D, Corvin, A, Gurling, H, Werge, T, Rujescu, D, Blackwood, D H, Pato, C N, Malhotra, A K, Purcell, S, Dudbridge, F, Neale, B M, Rossin, L, Visscher, P M, Posthuma, D, Ruderfer, D M, Fanous, A, Stefansson, H, Steinberg, S, Mowry, B J, Golimbet, V, de Hert, M, Jonsson, E G, Bitter, I, Pietilainen, O P, Collier, D A, Tosato, S, Agartz, I, Albus, M, Alexander, M, Amdur, R L, Amin, F, Bass, N, Bergen, S E, Black, D W, Borglum, A D, Brown, M A, Bruggeman, R, Buccola, N G, Byerley, W F, Cahn, W, Cantor, R M, Carr, V J, Catts, S V, Choudhury, K, Cloninger, C R, Cormican, P, Craddock, N, Danoy, P A, Datta, S, de Haan, L, Demontis, D, Dikeos, D, Djurovic, S, Donnely, P, Donohoe, G, Duong, L, Dwyer, S, Fink-Jensen, A, Freedman, R, Freimer, N B, Friedl, M, Georgieva, L, Giegling, I, Gill, M, Glenthoj, B, Godard, S, Hamshere, M, Hansen, M, Hartmann, A M, Henskens, F A, Hougaard, D M, Hultman, C M, Ingason, A, Jablensky, A V, Jakobsen, K D, Jay, M, Jurgens, G, Kahn, R S, Keller, M C, Kenis, G, Kenny, E, Kim, Y, Kirov, G K, Konnerth, H, Konte, B, Krabbendam, L, Krasucki, R, Lasseter, V K, Laurent, C, Lawrence, J, Lencz, T, Lerer, F B, Liang, K Y, Lichtenstein, P, Lieberman, J A, Linszen, D H, Lonnqvist, J, Loughland, C M, Maclean, A W, Maher, B S, Maier, W, Mallet, J, Malloy, P, Mattheisen, M, Mattingsdal, M, McGhee, K A, McGrath, J J, McIntosh, A, McLean, D E, McQuillin, A, Melle, I, Michie, P T, Milanova, V, Morris, D W, Mors, O, Mortensen, P B, Moskvina, V, Muglia, P, Myin-Germeys, I, Nertney, D A, Nestadt, G, Nielsen, J, Nikolov, I, Nordentoft, M, Norton, N, Nothen, M M, O'Dushlaine, C T, Olincy, A, Olsen, L, O'Neill, F A, Orntoft, T F, Owen, M J, Pantelis, C, Papadimitriou, G, Pato, M T, Peltonen, L, Petursson, H, Pickard, B, Pimm, J, Pulver, A E, Puri, V, Quested, D, Quinn, E M, Rasmussen, H B, Rethelyi, J M, Ribble, R, Rietschel, M, Riley, B P, Ruggeri, M, Schall, U, Schulze, T G, Schwab, S G, Scott, R J, Shi, J, Sigurdsson, E, Silvermann, J M, Spencer, C C, Stefansson, K, Strange, A, Strengman, E, Stroup, T S, Suvisaari, J, Terenius, L, Thirumalai, S, Thygesen, J H, Timm, S, Toncheva, D, van den Oord, E, van Os, J, van Winkel, R, Veldink, J, Walsh, D, Wang, A G, Wiersma, D, Wildenauer, D B, Williams, H J, Williams, N M, Wormley, B, Zammit, S, Sullivan, P F, O'Donovan, M C, Daly, M J & Gejman, P V 2011, ' Genome-wide association study identifies five new schizophrenia loci ', Nature Genetics, vol. 43, no. 10, pp. 969-976 . https://doi.org/10.1038/ng.940
Ripke, S, Sanders, A R, Kendler, K S, Levinson, D F, Sklar, P, Holmans, P A, Lin, D-Y, Duan, J, Ophoff, R A, Andreassen, O A, Scolnick, E, Cichon, S, St Clair, D, Corvin, A, Gurling, H, Werge, T, Rujescu, D, Blackwood, D H R, Pato, C N, Malhotra, A K, Purcell, S, Dudbridge, F, Neale, B M, Rossin, L, Visscher, P M, Posthuma, D, Ruderfer, D M, Fanous, A, Stefansson, H, Steinberg, S, Mowry, B J, Golimbet, V, De Hert, M, Jönsson, E G, Bitter, I, Pietiläinen, O P H, Collier, D A, Tosato, S, Agartz, I, Albus, M, Alexander, M, Amdur, R L, Amin, F, Bass, N, Bergen, S E, Black, D W, Hansen, T, Maclean, A W & McGhee, K A & McIntosh, A 2011, ' Genome-wide association study identifies five new schizophrenia loci ', Nature Genetics, vol. 43, no. 10, pp. 969-76 . https://doi.org/10.1038/ng.940
Nature Genetics, 43(10), 969-976. Nature Publishing Group
Nature Genetics, 43(10), 969-U77. Nature Publishing Group
Nature Genetics, 43(10), 969-977. Nature Publishing Group
Ripke, S, Sanders, A R, Kendler, K S, Levinson, D F, Sklar, P, Holmans, P A, Lin, D-Y, Duan, J, Ophoff, R A, Andreassen, O A, Scolnick, E, Cichon, S, St Clair, D, Corvin, A, Gurling, H, Werge, T, Rujescu, D, Blackwood, D H R, Pato, C N, Malhotra, A K, Purcell, S, Dudbridge, F, Neale, B M, Rossin, L, Visscher, P M, Posthuma, D, Ruderfer, D M, Fanous, A, Stefansson, H, Steinberg, S, Mowry, B J, Golimbet, V, De Hert, M, Jönsson, E G, Bitter, I, Pietiläinen, O P H, Collier, D A, Tosato, S, Agartz, I, Albus, M, Alexander, M, Amdur, R L, Amin, F, Bass, N, Børglum, A D, Demontis, D, Mors, O, Mortensen, P B, Nielsen, J, Orntoft, T F & The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium 2011, ' Genome-wide association study identifies five new schizophrenia loci ', Nature Genetics, vol. 43, no. 10, pp. 969-976 . https://doi.org/10.1038/ng.940

We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c250b303408324fb0ad1c6c86506e3
https://doi.org/10.1038/ng.940

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