Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Houfu Leng"'
Autor:
Houfu Leng, Hanlin Zhang, Linsen Li, Shuhao Zhang, Yanping Wang, Selina J. Chavda, Daria Galas-Filipowicz, Hantao Lou, Adel Ersek, Emma V. Morris, Erdinc Sezgin, Yi-Hsuan Lee, Yunsen Li, Ana Victoria Lechuga-Vieco, Mei Tian, Jian-Qing Mi, Kwee Yong, Qing Zhong, Claire M. Edwards, Anna Katharina Simon, Nicole J. Horwood
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here, the authors show that the glycosylceramide synthesis inhibitor and FDA approved drug Eliglustat inhibits autophagic degradation of TRAF3 which is a key step for osteoclast differentiation and thereby improves myeloma bone lesions.
Externí odkaz:
https://doaj.org/article/d3f4b2b671d34e5f9416142c53caf80d
Autor:
Kreepa G. Kooblall, Mark Stevenson, Michelle Stewart, Lachlan Harris, Oressia Zalucki, Hannah Dewhurst, Natalie Butterfield, Houfu Leng, Tertius A. Hough, Da Ma, Bernard Siow, Paul Potter, Roger D. Cox, Stephen D.M. Brown, Nicole Horwood, Benjamin Wright, Helen Lockstone, David Buck, Tonia L. Vincent, Fadil M. Hannan, J.H. Duncan Bassett, Graham R. Williams, Kate E. Lines, Michael Piper, Sara Wells, Lydia Teboul, Raoul C. Hennekam, Rajesh V. Thakker
Publikováno v:
JBMR Plus, Vol 7, Iss 6, Pp n/a-n/a (2023)
The nuclear factor I/X (NFIX) gene encodes a ubiquitously expressed transcription factor whose mutations lead to two allelic disorders characterized by developmental, skeletal, and neural abnormalities, namely, Malan syndrome (MAL) and Marshall–Smi
Externí odkaz:
https://doaj.org/article/e6e65049660d4723b8974df714e0b83f
Autor:
null Kreepa G. Kooblall, null Mark Stevenson, null Michelle Stewart, null Lachlan Harris, null Oressia Zalucki, null Hannah Dewhurst, null Natalie Butterfield, null Houfu Leng, null Tertius A. Hough, null Da Ma, null Bernard Siow, null Paul Potter, null Roger D. Cox, null Stephen D.M. Brown, null Nicole Horwood, null Benjamin Wright, null Helen Lockstone, null David Buck, null Tonia L. Vincent, null Fadil M. Hannan, null J.H. Duncan Bassett, null Graham R. Williams, null Kate E. Lines, null Michael Piper, null Sara Wells, null Lydia Teboul, null Raoul C. Hennekam, null Rajesh V. Thakker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc95ca703920ea3db5407b11d4acf4a
https://doi.org/10.1002/jbm4.10739/v3/response1
https://doi.org/10.1002/jbm4.10739/v3/response1
Autor:
Emma C. Morris, Yunsen Li, Hanlin Zhang, Kwee Yong, Adel Ersek, Qing Zhong, Erdinc Sezgin, Yi-Hsuan Lee, Claire M. Edwards, Anna Katharina Simon, Daria Galas-Filipowicz, Linsen Li, Shuhao Zhang, Nicole J. Horwood, Selina J Chavda, Jian-Qing Mi, Yanping Wang, Houfu Leng
Patients with multiple myeloma (MM), an incurable malignancy of plasma cells, frequently develop osteolytic bone lesions. In this study, glycosphingolipids were essential in promoting autophagic degradation of the signaling molecule TRAF3, a key step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d2705eea82dcb47ad2db52b4602677d
https://doi.org/10.21203/rs.3.rs-728824/v1
https://doi.org/10.21203/rs.3.rs-728824/v1
Autor:
Ceiridwen J. Edwards, Li L, Houfu Leng, Anna Katharina Simon, Erdinc Sezgin, Adel Ersek, Zhong Q, Nicole J. Horwood, Yi Xin Fiona Lee, Yong-Feng Wang, Mi J, Li Y, Hanlin Zhang, Suyi Zhang, Emma V. Morris
Multiple myeloma (MM) is a fatal hematological malignancy, where the majority of patients are diagnosed with, or develop, destructive and debilitating osteolytic bone lesions. Current treatments for MM bone disease such as the bisphosphonate zoledron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c9798cc254eba7398127aac37cad38b
https://doi.org/10.1101/2021.02.05.429906
https://doi.org/10.1101/2021.02.05.429906
Autor:
Sara Wells, Nicole J. Horwood, Raoul C.M. Hennekam, Mark Stevenson, Tonia L. Vincent, Houfu Leng, Roger D. Cox, Kreepa Kooblall, Paul Potter, Tertius Hough, Rajesh Thakker, Lydia Teboul, Michelle Stewart, Stephen D.M. Brown, Zsombor Szoke-Kovacs
Publikováno v:
Endocrine Abstracts.
Autor:
Adel Ersek, Houfu Leng, Nicole J. Horwood, Emma V. Morris, Claire M. Edwards, Beatriz Gamez Molina
Publikováno v:
Blood. 132:1942-1942
Multiple myeloma (MM) is an incurable cancer of plasma cells (PC), with a median survival of 5-7 years. Osteolytic bone disease and skeletal complications occur in more than 80% of MM patients and significantly contribute to the morbidity and mortali