Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Houfang Long"'
The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein
Autor:
Yunpeng Sun, Houfang Long, Wencheng Xia, Kun Wang, Xia Zhang, Bo Sun, Qin Cao, Yaoyang Zhang, Bin Dai, Dan Li, Cong Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
G51D mutation of α-synuclein (α-syn) causes a subset of familial Parkinson’s disease that is characterized by an early onset and rapid progression of the disease. Here, the authors present the cryo-EM structure of full-length G51D α-syn fibrils
Externí odkaz:
https://doaj.org/article/81e50c656ec049e6ac3e98871e08acb8
Autor:
Kun Zhao, Yaowang Li, Zhenying Liu, Houfang Long, Chunyu Zhao, Feng Luo, Yunpeng Sun, Youqi Tao, Xiao-dong Su, Dan Li, Xueming Li, Cong Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The E46K α-synuclein mutation causes familial Parkinson’s disease. Here, the authors present the cryo-EM structure of N-terminally acetylated E46K α-synuclein fibrils and find that it is distinct from other known α-synuclein fibril structures.
Externí odkaz:
https://doaj.org/article/cc9dbfd9711d43aea145abb7f8f9e3c5
Autor:
Xiaojuan Ma, Yi Zhu, Jinxia Lu, Jingfei Xie, Chong Li, Woo Shik Shin, Jiali Qiang, Jiaqi Liu, Shuai Dou, Yi Xiao, Chuchu Wang, Chunyu Jia, Houfang Long, Juntao Yang, Yanshan Fang, Lin Jiang, Yaoyang Zhang, Shengnan Zhang, Rong Grace Zhai, Cong Liu, Dan Li
Publikováno v:
eLife, Vol 9 (2020)
Tau hyper-phosphorylation and deposition into neurofibrillary tangles have been found in brains of patients with Alzheimer’s disease (AD) and other tauopathies. Molecular chaperones are involved in regulating the pathological aggregation of phospho
Externí odkaz:
https://doaj.org/article/7a6c38a74c5f4d10ba956531826059aa
Autor:
Fangru, Wang, Ting, Jin, Hongyuan, Li, Houfang, Long, Ying, Liu, Sha, Jin, Yuyuan, Lu, Yinghua, Peng, Cong, Liu, Lihui, Zhao, Xiaohui, Wang
Publikováno v:
The FASEB Journal. 37
Cannabidivarin (CBDV), a structural analog of cannabidiol (CBD), has received attention in recent years owing to its anticonvulsant property and potential for treating autism spectrum disorder. However, the function and mechanism of CBDV involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10674cb9567b059bcb9a35d5a1535004
https://doi.org/10.1096/fj.202200278rr
https://doi.org/10.1096/fj.202200278rr
Autor:
Fangru Wang, Ting Jin, Hongyuan Li, Houfang Long, Ying Liu, Sha Jin, Yuyuan Lu, Yinghua Peng, Cong Liu, Lihui Zhao, Xiaohui Wang
Publikováno v:
FASEB Journal; Feb2023, Vol. 37 Issue 2, p1-14, 14p
Autor:
Houfang Long, Cong Liu, Dan Li, Yunpeng Sun, Chunyu Zhao, Xueming Li, Yaowang Li, Feng Luo, Kun Zhao, Youqi Tao, Xiao-Dong Su, Zhenying Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Amyloid aggregation of α-synuclein (α-syn) is closely associated with Parkinson’s disease (PD) and other synucleinopathies. Several single amino-acid mutations (e.g. E46K) of α-syn have been identified causative to the early onset of familial PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64de2de18e2b8fbbc6da4a10d50b16c2
http://link.springer.com/article/10.1038/s41467-020-16386-3
http://link.springer.com/article/10.1038/s41467-020-16386-3
The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein
Autor:
Dan Li, Qin Cao, Bo Sun, Houfang Long, Cong Liu, Bin Dai, Kun Wang, Yaoyang Zhang, Wencheng Xia, Yunpeng Sun, Xia Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
α-Synuclein (α-Syn) can form different fibril strains with distinct polymorphs and neuropathologies, which is associated with the clinicopathological variability in synucleinopathies. How different α-syn fibril strains are produced and selected un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1bdd4205a0690907a03cde9a91e98f
https://doi.org/10.1038/s41467-021-26433-2
https://doi.org/10.1038/s41467-021-26433-2
Autor:
Chuchu Wang, Meng Rong Ma, Houfang Long, Youqi Tao, Xiaobo Mao, Shengnan Zhang, Chunyu Zhao, Cong Liu, Dan Li, Yeh Jun Lim, Zhijun Liu, Yan-Mei Li, Yu Qing Liu, Yasuyoshi Kimura, Guoqin Feng, Ted M. Dawson, Enquan Xu, Lin Jiang, Chunyu Jia, Valina L. Dawson, Zhenying Liu, Renxiao Wang, Jin Jian Hu
Publikováno v:
Proc Natl Acad Sci U S A
The spread of pathological α-synuclein (α-syn) is a crucial event in the progression of Parkinson's disease (PD). Cell surface receptors such as lymphocyte activation gene 3 (LAG3) and amyloid precursor-like protein 1 (APLP1) can preferentially bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46975d21336776f6dcf368202d4145bc
https://pubmed.ncbi.nlm.nih.gov/34172566
https://pubmed.ncbi.nlm.nih.gov/34172566
Autor:
Jing Gao, Yaoyang Zhang, Houfang Long, Shouqiao Hou, Zhenying Liu, Dan Li, Xiao-Dong Su, Yunpeng Sun, Cong Liu, Kun Zhao
Publikováno v:
Cell Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8786203c3e4f4ef99bf3a92d87df1f83
https://doi.org/10.1038/s41422-020-0299-4
https://doi.org/10.1038/s41422-020-0299-4
Autor:
Houfang Long, Kaiwen He, Cong Liu, Wencheng Xia, Shiran Lv, Yang Liu, Yunpeng Sun, Zhengtao Liu, Weitong Zheng, Zhenying Liu, Kun Zhao, Dan Li
Publikováno v:
Proc Natl Acad Sci U S A
Heterozygous point mutations of α-synuclein (α-syn) have been linked to the early onset and rapid progression of familial Parkinson's diseases (fPD). However, the interplay between hereditary mutant and wild-type (WT) α-syn and its role in the exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93aa20d21c102dc8279a3929701b95d8
https://doi.org/10.1073/pnas.2012435118
https://doi.org/10.1073/pnas.2012435118