Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Houda H. Harastani"'
Autor:
Juhee Son, Shimeng Huang, Qiru Zeng, Traci L. Bricker, James Brett Case, Jinzhu Zhou, Ruochen Zang, Zhuoming Liu, Xinjian Chang, Tamarand L. Darling, Jian Xu, Houda H. Harastani, Lu Chen, Maria Florencia Gomez Castro, Yongxiang Zhao, Hinissan P. Kohio, Gaopeng Hou, Baochao Fan, Beibei Niu, Rongli Guo, Paul W. Rothlauf, Adam L. Bailey, Xin Wang, Pei-Yong Shi, Elisabeth D. Martinez, Steven L. Brody, Sean P. J. Whelan, Michael S. Diamond, Adrianus C. M. Boon, Bin Li, Siyuan Ding
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Pathogenic coronaviruses are a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified small-molecule inhibitors that potently block the replication of severe acute resp
Externí odkaz:
https://doaj.org/article/9c29ed90b7cd4b61b729c1e9c1dba354
Autor:
Caleb D. Swaim, Varun Dwivedi, Yi-Chieh Perng, Xu Zhao, Larissa A. Canadeo, Houda H. Harastani, Tamarand L. Darling, Adrianus C.M. Boon, Deborah J. Lenschow, Viraj Kulkarni, Jon M. Huibregtse
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103213- (2021)
Summary: The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics. The papain-like protease (PLpro) activity of nsp3 is an attra
Externí odkaz:
https://doaj.org/article/2d628d8bb0d24099b4370a53d4b95c2c
Autor:
Wen Su, Sin Fun Sia, Aaron J. Schmitz, Traci L. Bricker, Tyler N. Starr, Allison J. Greaney, Jackson S. Turner, Bassem M. Mohammed, Zhuoming Liu, Ka Tim Choy, Tamarand L. Darling, Astha Joshi, Ka Man Cheng, Alvina Y. L. Wong, Houda H. Harastani, John M. Nicholls, Sean P. J. Whelan, Jesse D. Bloom, Hui-Ling Yen, Ali H. Ellebedy, Adrianus C. M. Boon
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-
Externí odkaz:
https://doaj.org/article/59017aa8fbfc49cca3569388d8d7b51e
Autor:
Christian Shema Mugisha, Hung R. Vuong, Maritza Puray-Chavez, Adam L. Bailey, Julie M. Fox, Rita E. Chen, Alex W. Wessel, Jason M. Scott, Houda H. Harastani, Adrianus C. M. Boon, Haina Shin, Sebla B. Kutluay
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions within just a few months, causing severe respiratory disease and mortality. Assays to monitor SARS-CoV-2 growth in vitro depend on time-consuming and costly R
Externí odkaz:
https://doaj.org/article/5fa8bcf9f0bd472e90df2dc12e6e4f5e
Autor:
Houda H. Harastani, Lina Reslan, Ahmad Sabra, Zainab Ali, Moza Hammadi, Soha Ghanem, Farah Hajar, Ghassan M. Matar, Ghassan S. Dbaibo, Hassan Zaraket
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Human rotavirus remains a major cause of gastroenteritis worldwide despite the availability of effective vaccines. In this study, we investigated the genetic diversity of rotaviruses circulating in Lebanon. We genetically characterized the VP4 and VP
Externí odkaz:
https://doaj.org/article/267faf6f1e8a474091346357a2df648f
Autor:
Hongbing Jiang, Astha Joshi, Tianyu Gan, Andrew B. Janowski, Chika Fujii, Traci L. Bricker, Tamarand L. Darling, Houda H. Harastani, Kuljeet Seehra, Hongwei Chen, Stephen Tahan, Ana Jung, Binita Febles, Joshua A. Blatter, Scott A. Handley, Bijal A. Parikh, David Wang, Adrianus C. M. Boon
Publikováno v:
bioRxiv
The stem-loop II motif (s2m) is a RNA structural element that is found in the 3’ untranslated region (UTR) of many RNA viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Though the motif was discovered over twenty-five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3029f38f116cef9747827e4faa14beaf
https://doi.org/10.1101/2023.03.15.532878
https://doi.org/10.1101/2023.03.15.532878
Autor:
Sin Fun Sia, Bassem M. Mohammed, Jackson S. Turner, Sean P. J. Whelan, Zhuoming Liu, Ka Man Cheng, Wen Su, Jesse D. Bloom, Tamarand L. Darling, Astha Joshi, Hui-Ling Yen, Traci L. Bricker, Alvina Y L Wong, Adrianus C. M. Boon, Allison J. Greaney, Houda H. Harastani, Aaron J. Schmitz, Tyler N. Starr, Ali H. Ellebedy, John M. Nicholls, Ka Tim Choy
Publikováno v:
mBio
mBio, Vol 12, Iss 5 (2021)
mBio, Vol 12, Iss 5 (2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-
Autor:
Haiyan Zhao, Ahmed O. Hassan, Michael J. Holtzman, Robyn S. Klein, Allison Soung, James Brett Case, Ya-Nan Dai, Michael S. Diamond, Adrianus C. M. Boon, Tamarand L. Darling, Traci L. Bricker, Adam L. Bailey, Houda H. Harastani, Daved H. Fremont, Xiaoping Jiang, Lucas J. Adams
Publikováno v:
Cell Reports
The development of an effective vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), is a global priority. Here, we compare the protective capacity of intranasal and
Autor:
Haina Shin, Rita E. Chen, Christian Shema Mugisha, Alex W. Wessel, Julie M. Fox, Adam L. Bailey, Sebla B. Kutluay, Houda H. Harastani, Adrianus C. M. Boon, Hung R. Vuong, Jason M. Scott, Maritza Puray-Chavez
Publikováno v:
mSphere
mSphere, Vol 5, Iss 5 (2020)
mSphere, Vol 5, Iss 5 (2020)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic, is continuing to cause immense respiratory disease and social and economic disruptions. Conventional assays that
Autor:
Larissa A. Canadeo, Caleb D. Swaim, Deborah J. Lenschow, Yi-Chieh Perng, Houda H. Harastani, Xu Zhao, Jon M. Huibregtse, Adrianus C. M. Boon, Tamarand L. Darling
Publikováno v:
bioRxiv
A recently emerged betacoronavirus, SARS-CoV-2, has led to a global health crisis that calls for the identification of effective therapeutics for COVID-19 disease. Coronavirus papain-like protease (PLpro) is an attractive drug target as it is essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bff3018263f2a3facd280e4cdce757
https://europepmc.org/articles/PMC7337375/
https://europepmc.org/articles/PMC7337375/