Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Houchao Tao"'
Autor:
Lu Liu, Zhihao Zhu, Fang Zhou, Dongxiang Xue, Tao Hu, Weiling Luo, Yanli Qiu, Dong Wu, Fei Zhao, Zhiping Le, Houchao Tao
Publikováno v:
ACS Omega, Vol 6, Iss 32, Pp 21087-21093 (2021)
Externí odkaz:
https://doaj.org/article/e6d2ebd4d9534d109b3ef4ce709345ba
Autor:
Dehua Yang, Qingtong Zhou, Viktorija Labroska, Shanshan Qin, Sanaz Darbalaei, Yiran Wu, Elita Yuliantie, Linshan Xie, Houchao Tao, Jianjun Cheng, Qing Liu, Suwen Zhao, Wenqing Shui, Yi Jiang, Ming-Wei Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-27 (2021)
Abstract As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made r
Externí odkaz:
https://doaj.org/article/5105491674ff49e3b4dcfd70db593de2
Autor:
Yueming Xu, Yuxia Wang, Yang Wang, Kaiwen Liu, Yao Peng, Deqiang Yao, Houchao Tao, Haiguang Liu, Gaojie Song
Publikováno v:
IUCrJ, Vol 6, Iss 6, Pp 996-1006 (2019)
The class B family of G-protein-coupled receptors (GPCRs) has long been a paradigm for peptide hormone recognition and signal transduction. One class B GPCR, the glucagon-like peptide-1 receptor (GLP-1R), has been considered as an anti-diabetes drug
Externí odkaz:
https://doaj.org/article/dfc11f5493104f83aa57e261a0b1bcd7
Autor:
Xiaoyu Chen, Yueming Xu, Lu Qu, Lijie Wu, Gye Won Han, Yu Guo, Yiran Wu, Qingtong Zhou, Qianqian Sun, Cenfeng Chu, Jie Yang, Liu Yang, Quan Wang, Shuguang Yuan, Ling Wang, Tao Hu, Houchao Tao, Yaping Sun, Yunpeng Song, Liaoyuan Hu, Zhi-Jie Liu, Raymond C. Stevens, Suwen Zhao, Dong Wu, Guisheng Zhong
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2936-2943.e4 (2019)
Summary: Adrenergic G-protein-coupled receptors (GPCRs) mediate different cellular signaling pathways in the presence of endogenous catecholamines and play important roles in both physiological and pathological conditions. Extensive studies have been
Externí odkaz:
https://doaj.org/article/47fe6739c20c4baf9693d9f56fa1dd29
Autor:
Xianjun Zhang, Fei Zhao, Yiran Wu, Jun Yang, Gye Won Han, Suwen Zhao, Andrii Ishchenko, Lintao Ye, Xi Lin, Kang Ding, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Cornelius Gati, Garrett Nelson, Mark S. Hunter, Michael A. Hanson, Vadim Cherezov, Raymond C. Stevens, Wenfu Tan, Houchao Tao, Fei Xu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and pro
Externí odkaz:
https://doaj.org/article/88765518aaa04e1c8dca48de84763ef5
Autor:
Jie Zhao, Jiazhi Liu, Xinnan Liu, Qi Cao, Hongbo Zhao, Lizhen Liu, Farong Ye, Can Wang, Hong Shao, Dongxiang Xue, Houchao Tao, Bin Li, Biao Yu, Ping Wang
Publikováno v:
Chinese Journal of Chemistry. 40:787-793
Autor:
Xiaohong Liu, Fahui Li, Jiangyun Wang, Kunio Hirata, Dongsheng Liu, Deqiang Yao, Xiaoyan Wang, Ling Shen, Lijie Wu, Tiandan Xu, Zhi-Jie Liu, Tian Hua, Alexandros Makriyannis, Laura M. Bohn, Houchao Tao, Yongze Li, Ling-Yun Yang
Publikováno v:
Journal of the American Chemical Society. 143:16320-16325
Due to the lack of genetically encoded probes for fluorine-19 nuclear magnetic resonance spectroscopy (19F NMR), its utility for probing eukaryotic membrane protein dynamics is limited. Here we report an efficient method for the genetic incorporation
Autor:
Fei Li, Dongxiang Xue, Cuixia Li, Fei Xu, Fang Zhou, Yang Liu, Kang Ding, Suwen Zhao, Zhihao Zhu, Yueming Xu, Zhiping Le, Houchao Tao
Publikováno v:
ChemistryOpen, Vol 10, Iss 10, Pp 1028-1032 (2021)
ChemistryOpen
ChemistryOpen
An underside binding site was recently identified in the transmembrane domain of smoothened receptor (SMO). Herein, we report efforts in the exploration of new insights into the interactions between the ligand and SMO. The hydantoin core in the middl
Autor:
Wanglong Lu, Suwen Zhao, Fei Xu, Fang Zhou, Guisheng Zhong, Dongxiang Xue, Tangjie Gu, Xiaoyan Liu, Rongyan Li, Yiran Wu, Yanli Qiu, Yueming Xu, Tao Hu, Houchao Tao, Fei Zhao, Simeng Zhao, Zhong-Xing Jiang
Publikováno v:
Journal of Medicinal Chemistry. 64:13830-13840
Class F G protein-coupled receptors are characterized by a large extracellular domain (ECD) in addition to the common transmembrane domain (TMD) with seven α-helixes. For smoothened receptor (SMO), structural studies revealed dissected ECD and TMD,
Autor:
Xiaochen Tian, Fei Zhao, Xiaoyang Li, Weiwu Ren, Xiaohan Hou, Xiaoli Zhang, Yang Wang, Houchao Tao
Publikováno v:
Asian Journal of Organic Chemistry. 10:2385-2396