Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Hou-zao Chen"'
Autor:
Ying-Ying Jin, Peng Zhang, Le-Le Liu, Xiang Zhao, Xiao-Qing Hu, Si-Zhe Liu, Ze-Kun Li, Qian Liu, Jian-Qiao Wang, De-Long Hao, Zhu-Qin Zhang, Hou-Zao Chen, De-Pei Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Despite the potential of small molecules and recombinant proteins to enhance the efficiency of homology-directed repair (HDR), single-stranded DNA (ssDNA) donors, as currently designed and chemically modified, remain suboptimal for precise g
Externí odkaz:
https://doaj.org/article/0ebf624eb8b44729962c9f2861c9c6f4
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 104995- (2024)
Summary: RNA splicing is an important RNA processing step required by multiexon protein-coding mRNAs and some noncoding RNAs. Precise RNA splicing is required for maintaining gene and cell function; however, mis-spliced RNA transcripts can lead to lo
Externí odkaz:
https://doaj.org/article/e4813d78d60542f8a750c20be371d2c1
Autor:
Yang-Nan Ding, Ting-Ting Wang, Shuang-Jie Lv, Xiaoqiang Tang, Zi-Yu Wei, Fang Yao, Han-Shi Xu, Yi-Nan Chen, Xiao-Man Wang, Hui-Yu Wang, He-Ping Wang, Zhu-Qin Zhang, Xiang Zhao, De-Long Hao, Li-Hong Sun, Zhou Zhou, Li Wang, Hou-Zao Chen, De-Pei Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating vascular disease due to the risk of aortic rupture and without effective treatments. The current
Externí odkaz:
https://doaj.org/article/dc82478bacfb4180958ea3c5c6a9a96f
Autor:
Xiao-Ru Ma, Xudong Zhu, Yujie Xiao, Hui-Min Gu, Shuang-Shuang Zheng, Liang Li, Fan Wang, Zhao-Jun Dong, Di-Xian Wang, Yang Wu, Chenyu Yang, Wenhong Jiang, Ke Yao, Yue Yin, Yang Zhang, Chao Peng, Lixia Gao, Zhuoxian Meng, Zeping Hu, Chong Liu, Li Li, Hou-Zao Chen, Yousheng Shu, Zhenyu Ju, Jing-Wei Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in
Externí odkaz:
https://doaj.org/article/5e54229427a044a9afccbf8998af649c
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/e97f58e6f7f34069a7fc81e8e13bade7
Autor:
Ran Zhang, Xu Wang, Jia-Hua Qu, Bing Liu, Peng Zhang, Tao Zhang, Peng-Cheng Fan, Xiao-Man Wang, Guang-Yuan Xiao, Ye Su, Yan Xie, Yue Liu, Jian-Fei Pei, Zhu-Qin Zhang, De-Long Hao, Ping Xu, Hou-Zao Chen, De-Pei Liu
Publikováno v:
iScience, Vol 17, Iss , Pp 155-166 (2019)
Summary: Both caloric restriction (CR) and mitochondrial proteostasis are linked to longevity, but how CR maintains mitochondrial proteostasis in mammals remains elusive. MicroRNAs (miRNAs) are well known for gene silencing in cytoplasm and have rece
Externí odkaz:
https://doaj.org/article/962fd19d90e94da1b512780b10c251e0
Autor:
Peng Xu, Ting-ting Wang, Xiu-zhen Liu, Nan-Yu Wang, Li-hong Sun, Zhu-qin Zhang, Hou-zao Chen, Xiang Lv, Yue Huang, De-Pei Liu
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2019)
Abstract Background Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. It has been reported that Sirtuin 6 (Sirt6), a member of
Externí odkaz:
https://doaj.org/article/b04515305a384f2c9e57bf5ee1a1ca61
Autor:
Fang Wang, Hou-Zao Chen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Vascular smooth muscle cells (VSMCs), located in the media of artery, play key roles in maintaining the normal vascular physiological functions. Abnormality in VSMCs is implicated in vascular diseases (VDs), including atherosclerosis, abdominal aorti
Externí odkaz:
https://doaj.org/article/e87acef30c634e3aa8bf084495741e44
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Cardiovascular diseases have become the leading cause of human death. Aging is an independent risk factor for cardiovascular diseases. Cardiac aging is associated with maladaptation of cellular metabolism, dysfunction (or senescence) of cardiomyocyte
Externí odkaz:
https://doaj.org/article/e393a9683ec74686bf5f5cad9e463e0a
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Diabetes-induced tissue injuries in target organs such as the kidney, heart, eye, liver, skin, and nervous system contribute significantly to the morbidity and mortality of diabetes. However, whether the lung should be considered a diabetic target or
Externí odkaz:
https://doaj.org/article/5de2a01f42a14c6c83c46ee92677f554