Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test

Autor: Igawa, Hideyuki, Takahashi, Masashi, Ikoma, Minoru, Kaku, Hiromi, Kakegawa, Keiko, Kina, Asato, Aida, Jumpei, Okuda, Shoki, Kawata, Yayoi, Noguchi, Toshihiro, Hotta, Natsu, Yamamoto, Syunsuke, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi

Publikováno v: In Bioorganic & Medicinal Chemistry 1 June 2016 24(11):2504-2518

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Bombesin receptor subtype-3-expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus.

Autor: Maruyama M; Cardiovascular and Metabolic Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan., Hotta N; Cardiovascular and Metabolic Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan., Nio Y; Extra Value Generation & General Medicine Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan., Hamagami K; Cardiovascular and Metabolic Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan., Nagi T; Central Nervous System Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan., Funata M; Biomolecular Research Laboratories Takeda Pharmaceutical Company Limited Kanagawa Japan., Sakamoto J; Biomolecular Research Laboratories Takeda Pharmaceutical Company Limited Kanagawa Japan., Nakakariya M; Drug Metabolism and Pharmacokinetics Research LaboratoriesTakeda Pharmaceutical Company Limited Kanagawa Japan., Amano N; Drug Metabolism and Pharmacokinetics Research LaboratoriesTakeda Pharmaceutical Company Limited Kanagawa Japan., Nishida M; Integrated Technology Research Laboratories Takeda Pharmaceutical Company Limited Kanagawa Japan., Okawa T; Central Nervous System Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan., Arikawa Y; Central Nervous System Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan., Sasaki S; Medicinal Chemistry Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Kanagawa Japan., Kasai S; Cardiovascular and Metabolic Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan., Nagisa Y; Cardiovascular and Metabolic Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan.; Present address: CVM Marketing Japan Pharma Business UnitTakeda Pharmaceutical Co. Ltd.12-10, Nihonbashi 2-Chome, Chuo-ku Tokyo 103-8686 Japan., Habata Y; Cardiovascular and Metabolic Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan.; Present address: Foods & Nutrients Yamanashi Gakuin Junior College Sakaori 2-4-5, Kofu Yamanashi 400-8575 Japan., Mori M; Cardiovascular and Metabolic Drug Discovery Unit Takeda Pharmaceutical Company Limited Kanagawa Japan.

Publikováno v: Brain and behavior [Brain Behav] 2017 Dec 15; Vol. 8 (1), pp. e00881. Date of Electronic Publication: 2017 Dec 15 (Print Publication: 2018).