In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection.

Autor: Bain, William, Ahn, Brian, Peñaloza, Hernán F, McElheny, Christi L, Tolman, Nathanial, van der Geest, Rick, Gonzalez-Ferrer, Shekina, Chen, Nathalie, An, Xiaojing, Hosuru, Ria, Tabary, Mohammadreza, Papke, Erin, Kohli, Naina, Farooq, Nauman, Bachman, William, Olonisakin, Tolani F, Xiong, Zeyu, Griffith, Marissa P, Sullivan, Mara, Franks, Jonathan

Publikováno v: Journal of Infectious Diseases; 7/15/2024, Vol. 230 Issue 1, p209-220, 12p

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection.

Autor: Bain W; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Veterans Health Administration Pittsburgh Healthcare System., Ahn B; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus School of Medicine, Denver, CO, USA., Peñaloza HF; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., McElheny CL; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Tolman N; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., van der Geest R; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Gonzalez-Ferrer S; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Chen N; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., An X; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Hosuru R; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Tabary M; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Papke E; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Kohli N; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Farooq N; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Bachman W; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Olonisakin TF; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Xiong Z; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Griffith MP; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Sullivan M; Center for Biologic Imaging, Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., Franks J; Center for Biologic Imaging, Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., Mustapha MM; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Iovleva A; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Suber T; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Shanks RQ; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., Ferreira VP; Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States., Stolz DB; Center for Biologic Imaging, Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., Van Tyne D; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Doi Y; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Lee JS; Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Pulmonary and Critical Care Medicine, Washington University in St. Louis, St. Louis, Missouri, United States.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 01. Date of Electronic Publication: 2023 Jun 01.